Summary | |
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Symbol | PPP1R15A |
Name | protein phosphatase 1, regulatory subunit 15A |
Aliases | GADD34; growth arrest and DNA-damage-inducible 34; protein phosphatase 1, regulatory (inhibitor) subunit 15A ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side Note=Associates with membranes via an N-terminal amphipathic intramembrane region. |
Domain |
PF10488 Phosphatase-1 catalytic subunit binding region |
Function |
Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. |
Biological Process |
GO:0001933 negative regulation of protein phosphorylation GO:0006356 regulation of transcription from RNA polymerase I promoter GO:0006360 transcription from RNA polymerase I promoter GO:0006413 translational initiation GO:0006417 regulation of translation GO:0006446 regulation of translational initiation GO:0006470 protein dephosphorylation GO:0006984 ER-nucleus signaling pathway GO:0006986 response to unfolded protein GO:0007050 cell cycle arrest GO:0010608 posttranscriptional regulation of gene expression GO:0010921 regulation of phosphatase activity GO:0010922 positive regulation of phosphatase activity GO:0010923 negative regulation of phosphatase activity GO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation GO:0016311 dephosphorylation GO:0018105 peptidyl-serine phosphorylation GO:0018209 peptidyl-serine modification GO:0030968 endoplasmic reticulum unfolded protein response GO:0032056 positive regulation of translation in response to stress GO:0032058 positive regulation of translational initiation in response to stress GO:0032515 negative regulation of phosphoprotein phosphatase activity GO:0032516 positive regulation of phosphoprotein phosphatase activity GO:0033135 regulation of peptidyl-serine phosphorylation GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0034248 regulation of cellular amide metabolic process GO:0034250 positive regulation of cellular amide metabolic process GO:0034620 cellular response to unfolded protein GO:0034976 response to endoplasmic reticulum stress GO:0035303 regulation of dephosphorylation GO:0035304 regulation of protein dephosphorylation GO:0035305 negative regulation of dephosphorylation GO:0035306 positive regulation of dephosphorylation GO:0035307 positive regulation of protein dephosphorylation GO:0035308 negative regulation of protein dephosphorylation GO:0035966 response to topologically incorrect protein GO:0035967 cellular response to topologically incorrect protein GO:0036490 regulation of translation in response to endoplasmic reticulum stress GO:0036491 regulation of translation initiation in response to endoplasmic reticulum stress GO:0036492 eiF2alpha phosphorylation in response to endoplasmic reticulum stress GO:0036496 regulation of translational initiation by eIF2 alpha dephosphorylation GO:0036497 eIF2alpha dephosphorylation in response to endoplasmic reticulum stress GO:0036499 PERK-mediated unfolded protein response GO:0042326 negative regulation of phosphorylation GO:0043555 regulation of translation in response to stress GO:0043558 regulation of translational initiation in response to stress GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress GO:0043620 regulation of DNA-templated transcription in response to stress GO:0043666 regulation of phosphoprotein phosphatase activity GO:0045727 positive regulation of translation GO:0045786 negative regulation of cell cycle GO:0045943 positive regulation of transcription from RNA polymerase I promoter GO:0045948 positive regulation of translational initiation GO:0051346 negative regulation of hydrolase activity GO:0060734 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070262 peptidyl-serine dephosphorylation GO:0070972 protein localization to endoplasmic reticulum GO:0097193 intrinsic apoptotic signaling pathway GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress GO:1900101 regulation of endoplasmic reticulum unfolded protein response GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response GO:1902308 regulation of peptidyl-serine dephosphorylation GO:1902310 positive regulation of peptidyl-serine dephosphorylation GO:1903573 negative regulation of response to endoplasmic reticulum stress GO:1903897 regulation of PERK-mediated unfolded protein response GO:1903898 negative regulation of PERK-mediated unfolded protein response GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation GO:1903916 regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation GO:1903917 positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation GO:1990441 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress |
Molecular Function |
GO:0008047 enzyme activator activity GO:0008157 protein phosphatase 1 binding GO:0008599 protein phosphatase type 1 regulator activity GO:0019208 phosphatase regulator activity GO:0019211 phosphatase activator activity GO:0019888 protein phosphatase regulator activity GO:0019902 phosphatase binding GO:0019903 protein phosphatase binding GO:0071862 protein phosphatase type 1 activator activity GO:0072542 protein phosphatase activator activity |
Cellular Component |
GO:0000164 protein phosphatase type 1 complex GO:0005741 mitochondrial outer membrane GO:0008287 protein serine/threonine phosphatase complex GO:0019867 outer membrane GO:0031968 organelle outer membrane GO:1903293 phosphatase complex |
KEGG |
hsa04141 Protein processing in endoplasmic reticulum |
Reactome |
R-HSA-2173788: Downregulation of TGF-beta receptor signaling R-HSA-162582: Signal Transduction R-HSA-170834: Signaling by TGF-beta Receptor Complex R-HSA-2173789: TGF-beta receptor signaling activates SMADs |
Summary | |
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Symbol | PPP1R15A |
Name | protein phosphatase 1, regulatory subunit 15A |
Aliases | GADD34; growth arrest and DNA-damage-inducible 34; protein phosphatase 1, regulatory (inhibitor) subunit 15A ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PPP1R15A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PPP1R15A |
Name | protein phosphatase 1, regulatory subunit 15A |
Aliases | GADD34; growth arrest and DNA-damage-inducible 34; protein phosphatase 1, regulatory (inhibitor) subunit 15A ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PPP1R15A in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PPP1R15A |
Name | protein phosphatase 1, regulatory subunit 15A |
Aliases | GADD34; growth arrest and DNA-damage-inducible 34; protein phosphatase 1, regulatory (inhibitor) subunit 15A ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PPP1R15A in various data sets.
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Points in the above scatter plot represent the mutation difference of PPP1R15A in various data sets.
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Summary | |
---|---|
Symbol | PPP1R15A |
Name | protein phosphatase 1, regulatory subunit 15A |
Aliases | GADD34; growth arrest and DNA-damage-inducible 34; protein phosphatase 1, regulatory (inhibitor) subunit 15A ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PPP1R15A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | PPP1R15A |
Name | protein phosphatase 1, regulatory subunit 15A |
Aliases | GADD34; growth arrest and DNA-damage-inducible 34; protein phosphatase 1, regulatory (inhibitor) subunit 15A ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PPP1R15A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PPP1R15A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | PPP1R15A |
Name | protein phosphatase 1, regulatory subunit 15A |
Aliases | GADD34; growth arrest and DNA-damage-inducible 34; protein phosphatase 1, regulatory (inhibitor) subunit 15A ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PPP1R15A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | PPP1R15A |
Name | protein phosphatase 1, regulatory subunit 15A |
Aliases | GADD34; growth arrest and DNA-damage-inducible 34; protein phosphatase 1, regulatory (inhibitor) subunit 15A ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PPP1R15A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PPP1R15A |
Name | protein phosphatase 1, regulatory subunit 15A |
Aliases | GADD34; growth arrest and DNA-damage-inducible 34; protein phosphatase 1, regulatory (inhibitor) subunit 15A ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PPP1R15A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PPP1R15A |
Name | protein phosphatase 1, regulatory subunit 15A |
Aliases | GADD34; growth arrest and DNA-damage-inducible 34; protein phosphatase 1, regulatory (inhibitor) subunit 15A ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PPP1R15A collected from DrugBank database. |
There is no record. |