Browse PPP1R3G

Summary
SymbolPPP1R3G
Nameprotein phosphatase 1, regulatory subunit 3G
Aliases protein phosphatase 1, regulatory (inhibitor) subunit 3G; putative protein phosphatase 1 regulatory inhibito ......
Chromosomal Location6p25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF03370 Carbohydrate/starch-binding module (family 21)
Function

Glycogen-targeting subunit for protein phosphatase 1 (PP1). Involved in the regulation of hepatic glycogenesis in a manner coupled to the fasting-feeding cycle and distinct from other glycogen-targeting subunits (By similarity).

> Gene Ontology
 
Biological Process GO:0000271 polysaccharide biosynthetic process
GO:0005976 polysaccharide metabolic process
GO:0005977 glycogen metabolic process
GO:0005978 glycogen biosynthetic process
GO:0005979 regulation of glycogen biosynthetic process
GO:0005996 monosaccharide metabolic process
GO:0006006 glucose metabolic process
GO:0006073 cellular glucan metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0006109 regulation of carbohydrate metabolic process
GO:0006112 energy reserve metabolic process
GO:0009250 glucan biosynthetic process
GO:0010675 regulation of cellular carbohydrate metabolic process
GO:0010676 positive regulation of cellular carbohydrate metabolic process
GO:0010906 regulation of glucose metabolic process
GO:0010907 positive regulation of glucose metabolic process
GO:0010962 regulation of glucan biosynthetic process
GO:0015980 energy derivation by oxidation of organic compounds
GO:0016051 carbohydrate biosynthetic process
GO:0019318 hexose metabolic process
GO:0032881 regulation of polysaccharide metabolic process
GO:0032885 regulation of polysaccharide biosynthetic process
GO:0033500 carbohydrate homeostasis
GO:0033692 cellular polysaccharide biosynthetic process
GO:0034637 cellular carbohydrate biosynthetic process
GO:0042593 glucose homeostasis
GO:0043255 regulation of carbohydrate biosynthetic process
GO:0043467 regulation of generation of precursor metabolites and energy
GO:0044042 glucan metabolic process
GO:0044262 cellular carbohydrate metabolic process
GO:0044264 cellular polysaccharide metabolic process
GO:0044723 single-organism carbohydrate metabolic process
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0045913 positive regulation of carbohydrate metabolic process
GO:0070873 regulation of glycogen metabolic process
GO:0070875 positive regulation of glycogen metabolic process
GO:2000465 regulation of glycogen (starch) synthase activity
GO:2000467 positive regulation of glycogen (starch) synthase activity
Molecular Function GO:0001871 pattern binding
GO:0019902 phosphatase binding
GO:0019903 protein phosphatase binding
GO:0030246 carbohydrate binding
GO:0030247 polysaccharide binding
GO:2001069 glycogen binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolPPP1R3G
Nameprotein phosphatase 1, regulatory subunit 3G
Aliases protein phosphatase 1, regulatory (inhibitor) subunit 3G; putative protein phosphatase 1 regulatory inhibito ......
Chromosomal Location6p25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PPP1R3G and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolPPP1R3G
Nameprotein phosphatase 1, regulatory subunit 3G
Aliases protein phosphatase 1, regulatory (inhibitor) subunit 3G; putative protein phosphatase 1 regulatory inhibito ......
Chromosomal Location6p25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PPP1R3G in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPPP1R3G
Nameprotein phosphatase 1, regulatory subunit 3G
Aliases protein phosphatase 1, regulatory (inhibitor) subunit 3G; putative protein phosphatase 1 regulatory inhibito ......
Chromosomal Location6p25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PPP1R3G in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.6630.0289
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.2690.0145
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2220.636
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9161.1380.18
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.9540.472
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.3730.378
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.080.883
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.8320.329
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.6340.521
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2620.749
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.2440.822
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1620.42
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolPPP1R3G
Nameprotein phosphatase 1, regulatory subunit 3G
Aliases protein phosphatase 1, regulatory (inhibitor) subunit 3G; putative protein phosphatase 1 regulatory inhibito ......
Chromosomal Location6p25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PPP1R3G. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPPP1R3G
Nameprotein phosphatase 1, regulatory subunit 3G
Aliases protein phosphatase 1, regulatory (inhibitor) subunit 3G; putative protein phosphatase 1 regulatory inhibito ......
Chromosomal Location6p25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PPP1R3G. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PPP1R3G.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPPP1R3G
Nameprotein phosphatase 1, regulatory subunit 3G
Aliases protein phosphatase 1, regulatory (inhibitor) subunit 3G; putative protein phosphatase 1 regulatory inhibito ......
Chromosomal Location6p25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PPP1R3G. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPPP1R3G
Nameprotein phosphatase 1, regulatory subunit 3G
Aliases protein phosphatase 1, regulatory (inhibitor) subunit 3G; putative protein phosphatase 1 regulatory inhibito ......
Chromosomal Location6p25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PPP1R3G expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPPP1R3G
Nameprotein phosphatase 1, regulatory subunit 3G
Aliases protein phosphatase 1, regulatory (inhibitor) subunit 3G; putative protein phosphatase 1 regulatory inhibito ......
Chromosomal Location6p25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PPP1R3G and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPPP1R3G
Nameprotein phosphatase 1, regulatory subunit 3G
Aliases protein phosphatase 1, regulatory (inhibitor) subunit 3G; putative protein phosphatase 1 regulatory inhibito ......
Chromosomal Location6p25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PPP1R3G collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.