Summary | |
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Symbol | PPP2R2D |
Name | protein phosphatase 2, regulatory subunit B, delta |
Aliases | MDS026; PP2A subunit B isoform delta; protein phosphatase 2, regulatory subunit B, delta isoform; PP2A subun ...... |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm |
Domain | - |
Function |
B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). |
Biological Process |
GO:0006470 protein dephosphorylation GO:0007067 mitotic nuclear division GO:0010458 exit from mitosis GO:0010921 regulation of phosphatase activity GO:0016311 dephosphorylation GO:0034047 regulation of protein phosphatase type 2A activity GO:0035303 regulation of dephosphorylation GO:0035304 regulation of protein dephosphorylation GO:0043666 regulation of phosphoprotein phosphatase activity GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0070262 peptidyl-serine dephosphorylation |
Molecular Function |
GO:0004721 phosphoprotein phosphatase activity GO:0004722 protein serine/threonine phosphatase activity GO:0008601 protein phosphatase type 2A regulator activity GO:0016791 phosphatase activity GO:0019208 phosphatase regulator activity GO:0019888 protein phosphatase regulator activity GO:0042578 phosphoric ester hydrolase activity |
Cellular Component |
GO:0000159 protein phosphatase type 2A complex GO:0008287 protein serine/threonine phosphatase complex GO:1903293 phosphatase complex |
KEGG |
hsa03015 mRNA surveillance pathway hsa04071 Sphingolipid signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04152 AMPK signaling pathway hsa04261 Adrenergic signaling in cardiomyocytes hsa04390 Hippo signaling pathway hsa04530 Tight junction hsa04728 Dopaminergic synapse |
Reactome |
R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-68886: M Phase R-HSA-2465910: MASTL Facilitates Mitotic Progression R-HSA-68875: Mitotic Prophase |
Summary | |
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Symbol | PPP2R2D |
Name | protein phosphatase 2, regulatory subunit B, delta |
Aliases | MDS026; PP2A subunit B isoform delta; protein phosphatase 2, regulatory subunit B, delta isoform; PP2A subun ...... |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PPP2R2D and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between PPP2R2D and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | PPP2R2D |
Name | protein phosphatase 2, regulatory subunit B, delta |
Aliases | MDS026; PP2A subunit B isoform delta; protein phosphatase 2, regulatory subunit B, delta isoform; PP2A subun ...... |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PPP2R2D in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PPP2R2D |
Name | protein phosphatase 2, regulatory subunit B, delta |
Aliases | MDS026; PP2A subunit B isoform delta; protein phosphatase 2, regulatory subunit B, delta isoform; PP2A subun ...... |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PPP2R2D in various data sets.
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Points in the above scatter plot represent the mutation difference of PPP2R2D in various data sets.
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Summary | |
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Symbol | PPP2R2D |
Name | protein phosphatase 2, regulatory subunit B, delta |
Aliases | MDS026; PP2A subunit B isoform delta; protein phosphatase 2, regulatory subunit B, delta isoform; PP2A subun ...... |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PPP2R2D. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PPP2R2D |
Name | protein phosphatase 2, regulatory subunit B, delta |
Aliases | MDS026; PP2A subunit B isoform delta; protein phosphatase 2, regulatory subunit B, delta isoform; PP2A subun ...... |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PPP2R2D. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PPP2R2D. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PPP2R2D |
Name | protein phosphatase 2, regulatory subunit B, delta |
Aliases | MDS026; PP2A subunit B isoform delta; protein phosphatase 2, regulatory subunit B, delta isoform; PP2A subun ...... |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PPP2R2D. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PPP2R2D |
Name | protein phosphatase 2, regulatory subunit B, delta |
Aliases | MDS026; PP2A subunit B isoform delta; protein phosphatase 2, regulatory subunit B, delta isoform; PP2A subun ...... |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PPP2R2D expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PPP2R2D |
Name | protein phosphatase 2, regulatory subunit B, delta |
Aliases | MDS026; PP2A subunit B isoform delta; protein phosphatase 2, regulatory subunit B, delta isoform; PP2A subun ...... |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PPP2R2D and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PPP2R2D |
Name | protein phosphatase 2, regulatory subunit B, delta |
Aliases | MDS026; PP2A subunit B isoform delta; protein phosphatase 2, regulatory subunit B, delta isoform; PP2A subun ...... |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PPP2R2D collected from DrugBank database. |
There is no record. |