Summary | |
---|---|
Symbol | PPP2R3C |
Name | protein phosphatase 2, regulatory subunit B'', gamma |
Aliases | FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ...... |
Chromosomal Location | 14q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Cytoplasm Note=Excluded from the nucleoli. Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis. |
Domain | - |
Function |
May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells. |
Biological Process |
GO:0000226 microtubule cytoskeleton organization GO:0001776 leukocyte homeostasis GO:0001782 B cell homeostasis GO:0002260 lymphocyte homeostasis GO:0002521 leukocyte differentiation GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002759 regulation of antimicrobial humoral response GO:0002831 regulation of response to biotic stimulus GO:0002920 regulation of humoral immune response GO:0003254 regulation of membrane depolarization GO:0006959 humoral immune response GO:0019730 antimicrobial humoral response GO:0030098 lymphocyte differentiation GO:0030183 B cell differentiation GO:0030865 cortical cytoskeleton organization GO:0032147 activation of protein kinase activity GO:0032844 regulation of homeostatic process GO:0033674 positive regulation of kinase activity GO:0042113 B cell activation GO:0042391 regulation of membrane potential GO:0043029 T cell homeostasis GO:0043900 regulation of multi-organism process GO:0045577 regulation of B cell differentiation GO:0045579 positive regulation of B cell differentiation GO:0045619 regulation of lymphocyte differentiation GO:0045621 positive regulation of lymphocyte differentiation GO:0045860 positive regulation of protein kinase activity GO:0048536 spleen development GO:0048872 homeostasis of number of cells GO:0050864 regulation of B cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050871 positive regulation of B cell activation GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051881 regulation of mitochondrial membrane potential GO:0051882 mitochondrial depolarization GO:0051899 membrane depolarization GO:0051900 regulation of mitochondrial depolarization GO:1902105 regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1903706 regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:2000021 regulation of ion homeostasis |
Molecular Function | - |
Cellular Component |
GO:0005813 centrosome GO:0005819 spindle |
KEGG |
hsa03015 mRNA surveillance pathway hsa04071 Sphingolipid signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04152 AMPK signaling pathway hsa04261 Adrenergic signaling in cardiomyocytes hsa04728 Dopaminergic synapse |
Reactome | - |
Summary | |
---|---|
Symbol | PPP2R3C |
Name | protein phosphatase 2, regulatory subunit B'', gamma |
Aliases | FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ...... |
Chromosomal Location | 14q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PPP2R3C and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PPP2R3C |
Name | protein phosphatase 2, regulatory subunit B'', gamma |
Aliases | FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ...... |
Chromosomal Location | 14q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of PPP2R3C in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | PPP2R3C |
Name | protein phosphatase 2, regulatory subunit B'', gamma |
Aliases | FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ...... |
Chromosomal Location | 14q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PPP2R3C in various data sets.
|
Points in the above scatter plot represent the mutation difference of PPP2R3C in various data sets.
|
Summary | |
---|---|
Symbol | PPP2R3C |
Name | protein phosphatase 2, regulatory subunit B'', gamma |
Aliases | FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ...... |
Chromosomal Location | 14q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PPP2R3C. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | PPP2R3C |
Name | protein phosphatase 2, regulatory subunit B'', gamma |
Aliases | FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ...... |
Chromosomal Location | 14q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PPP2R3C. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PPP2R3C. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | PPP2R3C |
Name | protein phosphatase 2, regulatory subunit B'', gamma |
Aliases | FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ...... |
Chromosomal Location | 14q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PPP2R3C. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | PPP2R3C |
Name | protein phosphatase 2, regulatory subunit B'', gamma |
Aliases | FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ...... |
Chromosomal Location | 14q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PPP2R3C expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PPP2R3C |
Name | protein phosphatase 2, regulatory subunit B'', gamma |
Aliases | FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ...... |
Chromosomal Location | 14q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PPP2R3C and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PPP2R3C |
Name | protein phosphatase 2, regulatory subunit B'', gamma |
Aliases | FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ...... |
Chromosomal Location | 14q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PPP2R3C collected from DrugBank database. |
There is no record. |