Browse PPP2R3C

Summary
SymbolPPP2R3C
Nameprotein phosphatase 2, regulatory subunit B'', gamma
Aliases FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ......
Chromosomal Location14q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Cytoplasm Note=Excluded from the nucleoli. Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis.
Domain -
Function

May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells.

> Gene Ontology
 
Biological Process GO:0000226 microtubule cytoskeleton organization
GO:0001776 leukocyte homeostasis
GO:0001782 B cell homeostasis
GO:0002260 lymphocyte homeostasis
GO:0002521 leukocyte differentiation
GO:0002694 regulation of leukocyte activation
GO:0002696 positive regulation of leukocyte activation
GO:0002759 regulation of antimicrobial humoral response
GO:0002831 regulation of response to biotic stimulus
GO:0002920 regulation of humoral immune response
GO:0003254 regulation of membrane depolarization
GO:0006959 humoral immune response
GO:0019730 antimicrobial humoral response
GO:0030098 lymphocyte differentiation
GO:0030183 B cell differentiation
GO:0030865 cortical cytoskeleton organization
GO:0032147 activation of protein kinase activity
GO:0032844 regulation of homeostatic process
GO:0033674 positive regulation of kinase activity
GO:0042113 B cell activation
GO:0042391 regulation of membrane potential
GO:0043029 T cell homeostasis
GO:0043900 regulation of multi-organism process
GO:0045577 regulation of B cell differentiation
GO:0045579 positive regulation of B cell differentiation
GO:0045619 regulation of lymphocyte differentiation
GO:0045621 positive regulation of lymphocyte differentiation
GO:0045860 positive regulation of protein kinase activity
GO:0048536 spleen development
GO:0048872 homeostasis of number of cells
GO:0050864 regulation of B cell activation
GO:0050865 regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0050871 positive regulation of B cell activation
GO:0051249 regulation of lymphocyte activation
GO:0051251 positive regulation of lymphocyte activation
GO:0051881 regulation of mitochondrial membrane potential
GO:0051882 mitochondrial depolarization
GO:0051899 membrane depolarization
GO:0051900 regulation of mitochondrial depolarization
GO:1902105 regulation of leukocyte differentiation
GO:1902107 positive regulation of leukocyte differentiation
GO:1903706 regulation of hemopoiesis
GO:1903708 positive regulation of hemopoiesis
GO:2000021 regulation of ion homeostasis
Molecular Function -
Cellular Component GO:0005813 centrosome
GO:0005819 spindle
> KEGG and Reactome Pathway
 
KEGG hsa03015 mRNA surveillance pathway
hsa04071 Sphingolipid signaling pathway
hsa04151 PI3K-Akt signaling pathway
hsa04152 AMPK signaling pathway
hsa04261 Adrenergic signaling in cardiomyocytes
hsa04728 Dopaminergic synapse
Reactome -
Summary
SymbolPPP2R3C
Nameprotein phosphatase 2, regulatory subunit B'', gamma
Aliases FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ......
Chromosomal Location14q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PPP2R3C and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolPPP2R3C
Nameprotein phosphatase 2, regulatory subunit B'', gamma
Aliases FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ......
Chromosomal Location14q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PPP2R3C in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen Total # shRNA with >= 4-fold: 1 Resistant to T-cell proliferation
24476824shRNAmelanomaB16Secondary screen Total # shRNA with >= 4-fold: 1 Resistant to T-cell proliferation
Summary
SymbolPPP2R3C
Nameprotein phosphatase 2, regulatory subunit B'', gamma
Aliases FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ......
Chromosomal Location14q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PPP2R3C in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2110.336
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.5930.747
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0710.959
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1580.661
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.7260.559
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.5580.711
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1970.566
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1860.903
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.2040.904
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1130.937
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.3760.865
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0030.966
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PPP2R3C in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPPP2R3C
Nameprotein phosphatase 2, regulatory subunit B'', gamma
Aliases FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ......
Chromosomal Location14q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PPP2R3C. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPPP2R3C
Nameprotein phosphatase 2, regulatory subunit B'', gamma
Aliases FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ......
Chromosomal Location14q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PPP2R3C. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PPP2R3C.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPPP2R3C
Nameprotein phosphatase 2, regulatory subunit B'', gamma
Aliases FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ......
Chromosomal Location14q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PPP2R3C. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPPP2R3C
Nameprotein phosphatase 2, regulatory subunit B'', gamma
Aliases FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ......
Chromosomal Location14q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PPP2R3C expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPPP2R3C
Nameprotein phosphatase 2, regulatory subunit B'', gamma
Aliases FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ......
Chromosomal Location14q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PPP2R3C and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPPP2R3C
Nameprotein phosphatase 2, regulatory subunit B'', gamma
Aliases FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ......
Chromosomal Location14q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PPP2R3C collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.