Browse PPP3R1

Summary
SymbolPPP3R1
Nameprotein phosphatase 3, regulatory subunit B, alpha
Aliases CALNB1; CNB; CNB1; calcineurin B, type I (19kDa); protein phosphatase 2B regulatory subunit B alpha; protein ......
Chromosomal Location2p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm, cytosol Cell membrane Cell membrane, sarcolemma. Membrane Lipid-anchor Note=Translocates from the cytosol to the sarcolemma in a CIB1-dependent manner during cardiomyocytes hypertrophy.
Domain PF13499 EF-hand domain pair
Function

Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

> Gene Ontology
 
Biological Process GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0002764 immune response-regulating signaling pathway
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0006470 protein dephosphorylation
GO:0006606 protein import into nucleus
GO:0006839 mitochondrial transport
GO:0006913 nucleocytoplasmic transport
GO:0007006 mitochondrial membrane organization
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0008637 apoptotic mitochondrial changes
GO:0010821 regulation of mitochondrion organization
GO:0010822 positive regulation of mitochondrion organization
GO:0016055 Wnt signaling pathway
GO:0016311 dephosphorylation
GO:0017038 protein import
GO:0019722 calcium-mediated signaling
GO:0019932 second-messenger-mediated signaling
GO:0032386 regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0033157 regulation of intracellular protein transport
GO:0033173 calcineurin-NFAT signaling cascade
GO:0034504 protein localization to nucleus
GO:0035567 non-canonical Wnt signaling pathway
GO:0035794 positive regulation of mitochondrial membrane permeability
GO:0038093 Fc receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042306 regulation of protein import into nucleus
GO:0042307 positive regulation of protein import into nucleus
GO:0042990 regulation of transcription factor import into nucleus
GO:0042991 transcription factor import into nucleus
GO:0042993 positive regulation of transcription factor import into nucleus
GO:0044744 protein targeting to nucleus
GO:0046822 regulation of nucleocytoplasmic transport
GO:0046824 positive regulation of nucleocytoplasmic transport
GO:0046902 regulation of mitochondrial membrane permeability
GO:0048016 inositol phosphate-mediated signaling
GO:0051169 nuclear transport
GO:0051170 nuclear import
GO:0051204 protein insertion into mitochondrial membrane
GO:0051205 protein insertion into membrane
GO:0051222 positive regulation of protein transport
GO:0051531 NFAT protein import into nucleus
GO:0051532 regulation of NFAT protein import into nucleus
GO:0051533 positive regulation of NFAT protein import into nucleus
GO:0070585 protein localization to mitochondrion
GO:0072655 establishment of protein localization to mitochondrion
GO:0072657 protein localization to membrane
GO:0090150 establishment of protein localization to membrane
GO:0090316 positive regulation of intracellular protein transport
GO:0090559 regulation of membrane permeability
GO:0097345 mitochondrial outer membrane permeabilization
GO:0097720 calcineurin-mediated signaling
GO:0198738 cell-cell signaling by wnt
GO:1900180 regulation of protein localization to nucleus
GO:1900182 positive regulation of protein localization to nucleus
GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902593 single-organism nuclear import
GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death
GO:1903533 regulation of protein targeting
GO:1903747 regulation of establishment of protein localization to mitochondrion
GO:1903749 positive regulation of establishment of protein localization to mitochondrion
GO:1903829 positive regulation of cellular protein localization
GO:1904589 regulation of protein import
GO:1904591 positive regulation of protein import
GO:1904951 positive regulation of establishment of protein localization
GO:2001233 regulation of apoptotic signaling pathway
GO:2001235 positive regulation of apoptotic signaling pathway
Molecular Function GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0004723 calcium-dependent protein serine/threonine phosphatase activity
GO:0005516 calmodulin binding
GO:0016791 phosphatase activity
GO:0042578 phosphoric ester hydrolase activity
Cellular Component GO:0005955 calcineurin complex
GO:0008287 protein serine/threonine phosphatase complex
GO:0042383 sarcolemma
GO:1903293 phosphatase complex
> KEGG and Reactome Pathway
 
KEGG hsa04010 MAPK signaling pathway
hsa04020 Calcium signaling pathway
hsa04022 cGMP-PKG signaling pathway
hsa04114 Oocyte meiosis
hsa04310 Wnt signaling pathway
hsa04360 Axon guidance
hsa04370 VEGF signaling pathway
hsa04380 Osteoclast differentiation
hsa04650 Natural killer cell mediated cytotoxicity
hsa04660 T cell receptor signaling pathway
hsa04662 B cell receptor signaling pathway
hsa04720 Long-term potentiation
hsa04724 Glutamatergic synapse
hsa04921 Oxytocin signaling pathway
hsa04922 Glucagon signaling pathway
Reactome R-HSA-111447: Activation of BAD and translocation to mitochondria
R-HSA-114452: Activation of BH3-only proteins
R-HSA-109581: Apoptosis
R-HSA-3858494: Beta-catenin independent WNT signaling
R-HSA-5621481: C-type lectin receptors (CLRs)
R-HSA-5607763: CLEC7A (Dectin-1) induces NFAT activation
R-HSA-5607764: CLEC7A (Dectin-1) signaling
R-HSA-4086398: Ca2+ pathway
R-HSA-180024: DARPP-32 events
R-HSA-2871809: FCERI mediated Ca+2 mobilization
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-109606: Intrinsic Pathway for Apoptosis
R-HSA-111885: Opioid Signalling
R-HSA-5357801: Programmed Cell Death
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
R-HSA-195721: Signaling by Wnt
Summary
SymbolPPP3R1
Nameprotein phosphatase 3, regulatory subunit B, alpha
Aliases CALNB1; CNB; CNB1; calcineurin B, type I (19kDa); protein phosphatase 2B regulatory subunit B alpha; protein ......
Chromosomal Location2p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PPP3R1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolPPP3R1
Nameprotein phosphatase 3, regulatory subunit B, alpha
Aliases CALNB1; CNB; CNB1; calcineurin B, type I (19kDa); protein phosphatase 2B regulatory subunit B alpha; protein ......
Chromosomal Location2p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PPP3R1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen Total # shRNA with >= 4-fold: 2 Resistant to T-cell proliferation
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolPPP3R1
Nameprotein phosphatase 3, regulatory subunit B, alpha
Aliases CALNB1; CNB; CNB1; calcineurin B, type I (19kDa); protein phosphatase 2B regulatory subunit B alpha; protein ......
Chromosomal Location2p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PPP3R1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0910.626
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.190.935
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0250.988
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0830.765
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.2830.866
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.5440.797
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0510.901
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0590.975
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0410.984
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1490.914
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.7670.71
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0520.33
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PPP3R1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPPP3R1
Nameprotein phosphatase 3, regulatory subunit B, alpha
Aliases CALNB1; CNB; CNB1; calcineurin B, type I (19kDa); protein phosphatase 2B regulatory subunit B alpha; protein ......
Chromosomal Location2p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PPP3R1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPPP3R1
Nameprotein phosphatase 3, regulatory subunit B, alpha
Aliases CALNB1; CNB; CNB1; calcineurin B, type I (19kDa); protein phosphatase 2B regulatory subunit B alpha; protein ......
Chromosomal Location2p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PPP3R1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PPP3R1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPPP3R1
Nameprotein phosphatase 3, regulatory subunit B, alpha
Aliases CALNB1; CNB; CNB1; calcineurin B, type I (19kDa); protein phosphatase 2B regulatory subunit B alpha; protein ......
Chromosomal Location2p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PPP3R1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPPP3R1
Nameprotein phosphatase 3, regulatory subunit B, alpha
Aliases CALNB1; CNB; CNB1; calcineurin B, type I (19kDa); protein phosphatase 2B regulatory subunit B alpha; protein ......
Chromosomal Location2p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PPP3R1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPPP3R1
Nameprotein phosphatase 3, regulatory subunit B, alpha
Aliases CALNB1; CNB; CNB1; calcineurin B, type I (19kDa); protein phosphatase 2B regulatory subunit B alpha; protein ......
Chromosomal Location2p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PPP3R1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPPP3R1
Nameprotein phosphatase 3, regulatory subunit B, alpha
Aliases CALNB1; CNB; CNB1; calcineurin B, type I (19kDa); protein phosphatase 2B regulatory subunit B alpha; protein ......
Chromosomal Location2p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PPP3R1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting PPP3R1.
ID Name Drug Type Targets #Targets
DB08231Myristic acidSmall MoleculeABL1, ARF1, ARF6, ECI2, FKBP1A, GM2A, GUCA1A, HNF4A, INS, LY96, NC ......20
DB11693VoclosporinSmall MoleculePPP3R1, PPP3R22