Summary | |
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Symbol | PPP4R4 |
Name | protein phosphatase 4, regulatory subunit 4 |
Aliases | PP4R4; CFAP14; cilia and flagella associated protein 14; KIAA1622; HEAT-like repeat-containing protein; Seri ...... |
Chromosomal Location | 14q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm |
Domain | - |
Function |
Putative regulatory subunit of serine/threonine-protein phosphatase 4. |
Biological Process |
GO:0006470 protein dephosphorylation GO:0010921 regulation of phosphatase activity GO:0010923 negative regulation of phosphatase activity GO:0016311 dephosphorylation GO:0032515 negative regulation of phosphoprotein phosphatase activity GO:0035303 regulation of dephosphorylation GO:0035304 regulation of protein dephosphorylation GO:0035305 negative regulation of dephosphorylation GO:0035308 negative regulation of protein dephosphorylation GO:0043666 regulation of phosphoprotein phosphatase activity GO:0051346 negative regulation of hydrolase activity GO:0080163 regulation of protein serine/threonine phosphatase activity |
Molecular Function |
GO:0019208 phosphatase regulator activity GO:0019888 protein phosphatase regulator activity |
Cellular Component |
GO:0008287 protein serine/threonine phosphatase complex GO:1903293 phosphatase complex |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | PPP4R4 |
Name | protein phosphatase 4, regulatory subunit 4 |
Aliases | PP4R4; CFAP14; cilia and flagella associated protein 14; KIAA1622; HEAT-like repeat-containing protein; Seri ...... |
Chromosomal Location | 14q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PPP4R4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PPP4R4 |
Name | protein phosphatase 4, regulatory subunit 4 |
Aliases | PP4R4; CFAP14; cilia and flagella associated protein 14; KIAA1622; HEAT-like repeat-containing protein; Seri ...... |
Chromosomal Location | 14q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PPP4R4 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PPP4R4 |
Name | protein phosphatase 4, regulatory subunit 4 |
Aliases | PP4R4; CFAP14; cilia and flagella associated protein 14; KIAA1622; HEAT-like repeat-containing protein; Seri ...... |
Chromosomal Location | 14q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PPP4R4 in various data sets.
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Points in the above scatter plot represent the mutation difference of PPP4R4 in various data sets.
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Summary | |
---|---|
Symbol | PPP4R4 |
Name | protein phosphatase 4, regulatory subunit 4 |
Aliases | PP4R4; CFAP14; cilia and flagella associated protein 14; KIAA1622; HEAT-like repeat-containing protein; Seri ...... |
Chromosomal Location | 14q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PPP4R4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | PPP4R4 |
Name | protein phosphatase 4, regulatory subunit 4 |
Aliases | PP4R4; CFAP14; cilia and flagella associated protein 14; KIAA1622; HEAT-like repeat-containing protein; Seri ...... |
Chromosomal Location | 14q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PPP4R4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PPP4R4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | PPP4R4 |
Name | protein phosphatase 4, regulatory subunit 4 |
Aliases | PP4R4; CFAP14; cilia and flagella associated protein 14; KIAA1622; HEAT-like repeat-containing protein; Seri ...... |
Chromosomal Location | 14q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PPP4R4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | PPP4R4 |
Name | protein phosphatase 4, regulatory subunit 4 |
Aliases | PP4R4; CFAP14; cilia and flagella associated protein 14; KIAA1622; HEAT-like repeat-containing protein; Seri ...... |
Chromosomal Location | 14q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PPP4R4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PPP4R4 |
Name | protein phosphatase 4, regulatory subunit 4 |
Aliases | PP4R4; CFAP14; cilia and flagella associated protein 14; KIAA1622; HEAT-like repeat-containing protein; Seri ...... |
Chromosomal Location | 14q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PPP4R4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PPP4R4 |
Name | protein phosphatase 4, regulatory subunit 4 |
Aliases | PP4R4; CFAP14; cilia and flagella associated protein 14; KIAA1622; HEAT-like repeat-containing protein; Seri ...... |
Chromosomal Location | 14q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PPP4R4 collected from DrugBank database. |
There is no record. |