Summary | |
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Symbol | PRDM6 |
Name | PR domain containing 6 |
Aliases | PR domain zinc finger protein 6; PR domain-containing protein 6; PR-domain zinc finger protein 6; Putative h ...... |
Chromosomal Location | 5q21-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF00856 SET domain |
Function |
Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression. |
Biological Process |
GO:0006479 protein methylation GO:0008213 protein alkylation GO:0016570 histone modification GO:0016571 histone methylation GO:0018022 peptidyl-lysine methylation GO:0018205 peptidyl-lysine modification GO:0032259 methylation GO:0034968 histone lysine methylation GO:0042692 muscle cell differentiation GO:0043414 macromolecule methylation GO:0051145 smooth muscle cell differentiation GO:0051147 regulation of muscle cell differentiation GO:0051148 negative regulation of muscle cell differentiation GO:0051150 regulation of smooth muscle cell differentiation GO:0051151 negative regulation of smooth muscle cell differentiation |
Molecular Function |
GO:0008168 methyltransferase activity GO:0008170 N-methyltransferase activity GO:0008276 protein methyltransferase activity GO:0008757 S-adenosylmethionine-dependent methyltransferase activity GO:0016278 lysine N-methyltransferase activity GO:0016279 protein-lysine N-methyltransferase activity GO:0016741 transferase activity, transferring one-carbon groups GO:0018024 histone-lysine N-methyltransferase activity GO:0042054 histone methyltransferase activity |
Cellular Component | - |
KEGG |
hsa00310 Lysine degradation |
Reactome | - |
Summary | |
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Symbol | PRDM6 |
Name | PR domain containing 6 |
Aliases | PR domain zinc finger protein 6; PR domain-containing protein 6; PR-domain zinc finger protein 6; Putative h ...... |
Chromosomal Location | 5q21-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PRDM6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PRDM6 |
Name | PR domain containing 6 |
Aliases | PR domain zinc finger protein 6; PR domain-containing protein 6; PR-domain zinc finger protein 6; Putative h ...... |
Chromosomal Location | 5q21-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PRDM6 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PRDM6 |
Name | PR domain containing 6 |
Aliases | PR domain zinc finger protein 6; PR domain-containing protein 6; PR-domain zinc finger protein 6; Putative h ...... |
Chromosomal Location | 5q21-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PRDM6 in various data sets.
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Points in the above scatter plot represent the mutation difference of PRDM6 in various data sets.
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Summary | |
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Symbol | PRDM6 |
Name | PR domain containing 6 |
Aliases | PR domain zinc finger protein 6; PR domain-containing protein 6; PR-domain zinc finger protein 6; Putative h ...... |
Chromosomal Location | 5q21-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PRDM6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PRDM6 |
Name | PR domain containing 6 |
Aliases | PR domain zinc finger protein 6; PR domain-containing protein 6; PR-domain zinc finger protein 6; Putative h ...... |
Chromosomal Location | 5q21-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PRDM6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PRDM6. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PRDM6 |
Name | PR domain containing 6 |
Aliases | PR domain zinc finger protein 6; PR domain-containing protein 6; PR-domain zinc finger protein 6; Putative h ...... |
Chromosomal Location | 5q21-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PRDM6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | PRDM6 |
Name | PR domain containing 6 |
Aliases | PR domain zinc finger protein 6; PR domain-containing protein 6; PR-domain zinc finger protein 6; Putative h ...... |
Chromosomal Location | 5q21-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PRDM6 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PRDM6 |
Name | PR domain containing 6 |
Aliases | PR domain zinc finger protein 6; PR domain-containing protein 6; PR-domain zinc finger protein 6; Putative h ...... |
Chromosomal Location | 5q21-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PRDM6 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PRDM6 |
Name | PR domain containing 6 |
Aliases | PR domain zinc finger protein 6; PR domain-containing protein 6; PR-domain zinc finger protein 6; Putative h ...... |
Chromosomal Location | 5q21-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PRDM6 collected from DrugBank database. |
There is no record. |