Summary | |
---|---|
Symbol | PRDM8 |
Name | PR domain containing 8 |
Aliases | PFM5; PR domain-containing protein 8; PR-domain containing protein 8; PR domain zinc finger protein 8 |
Chromosomal Location | 4q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain | - |
Function |
Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (By similarity). Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (By similarity). Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (By similarity). In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival (By similarity). |
Biological Process |
GO:0010001 glial cell differentiation GO:0014003 oligodendrocyte development GO:0021782 glial cell development GO:0032259 methylation GO:0042063 gliogenesis GO:0048709 oligodendrocyte differentiation |
Molecular Function |
GO:0008168 methyltransferase activity GO:0016741 transferase activity, transferring one-carbon groups |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | PRDM8 |
Name | PR domain containing 8 |
Aliases | PFM5; PR domain-containing protein 8; PR-domain containing protein 8; PR domain zinc finger protein 8 |
Chromosomal Location | 4q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PRDM8 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PRDM8 |
Name | PR domain containing 8 |
Aliases | PFM5; PR domain-containing protein 8; PR-domain containing protein 8; PR domain zinc finger protein 8 |
Chromosomal Location | 4q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of PRDM8 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | PRDM8 |
Name | PR domain containing 8 |
Aliases | PFM5; PR domain-containing protein 8; PR-domain containing protein 8; PR domain zinc finger protein 8 |
Chromosomal Location | 4q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PRDM8 in various data sets.
|
Points in the above scatter plot represent the mutation difference of PRDM8 in various data sets.
|
Summary | |
---|---|
Symbol | PRDM8 |
Name | PR domain containing 8 |
Aliases | PFM5; PR domain-containing protein 8; PR-domain containing protein 8; PR domain zinc finger protein 8 |
Chromosomal Location | 4q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PRDM8. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | PRDM8 |
Name | PR domain containing 8 |
Aliases | PFM5; PR domain-containing protein 8; PR-domain containing protein 8; PR domain zinc finger protein 8 |
Chromosomal Location | 4q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PRDM8. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PRDM8. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | PRDM8 |
Name | PR domain containing 8 |
Aliases | PFM5; PR domain-containing protein 8; PR-domain containing protein 8; PR domain zinc finger protein 8 |
Chromosomal Location | 4q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PRDM8. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | PRDM8 |
Name | PR domain containing 8 |
Aliases | PFM5; PR domain-containing protein 8; PR-domain containing protein 8; PR domain zinc finger protein 8 |
Chromosomal Location | 4q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PRDM8 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PRDM8 |
Name | PR domain containing 8 |
Aliases | PFM5; PR domain-containing protein 8; PR-domain containing protein 8; PR domain zinc finger protein 8 |
Chromosomal Location | 4q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PRDM8 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PRDM8 |
Name | PR domain containing 8 |
Aliases | PFM5; PR domain-containing protein 8; PR-domain containing protein 8; PR domain zinc finger protein 8 |
Chromosomal Location | 4q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PRDM8 collected from DrugBank database. |
There is no record. |