Summary | |
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Symbol | PRF1 |
Name | perforin 1 (pore forming protein) |
Aliases | PFP; HPLH2; Perforin; perforin 1 (preforming protein); FLH2; cytolysin; lymphocyte pore forming protein; lym ...... |
Chromosomal Location | 10q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasmic granule lumen. Secreted. Cell membrane; Multi-pass membrane protein. Endosome lumen. Note=Stored in cytoplasmic granules of cytolytic T-lymphocytes and secreted into the cleft between T-lymphocyte and target cell. Inserts into the cell membrane of target cells and forms pores. Membrane insertion and pore formation requires a major conformation change. May be taken up via endocytosis involving clathrin-coated vesicles and accumulate in a first time in large early endosomes. |
Domain |
PF00168 C2 domain PF01823 MAC/Perforin domain |
Function |
Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. |
Biological Process |
GO:0001771 immunological synapse formation GO:0002347 response to tumor cell GO:0002357 defense response to tumor cell GO:0002418 immune response to tumor cell GO:0006968 cellular defense response GO:0008037 cell recognition GO:0009615 response to virus GO:0009988 cell-cell recognition GO:0019835 cytolysis GO:0051259 protein oligomerization GO:0051260 protein homooligomerization GO:0051607 defense response to virus GO:0098542 defense response to other organism |
Molecular Function |
GO:0015267 channel activity GO:0022803 passive transmembrane transporter activity GO:0022829 wide pore channel activity |
Cellular Component |
GO:0005775 vacuolar lumen GO:0031904 endosome lumen GO:0044194 cytolytic granule GO:0044440 endosomal part |
KEGG |
hsa04210 Apoptosis hsa04650 Natural killer cell mediated cytotoxicity |
Reactome | - |
Summary | |
---|---|
Symbol | PRF1 |
Name | perforin 1 (pore forming protein) |
Aliases | PFP; HPLH2; Perforin; perforin 1 (preforming protein); FLH2; cytolysin; lymphocyte pore forming protein; lym ...... |
Chromosomal Location | 10q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PRF1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between PRF1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | PRF1 |
Name | perforin 1 (pore forming protein) |
Aliases | PFP; HPLH2; Perforin; perforin 1 (preforming protein); FLH2; cytolysin; lymphocyte pore forming protein; lym ...... |
Chromosomal Location | 10q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PRF1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PRF1 |
Name | perforin 1 (pore forming protein) |
Aliases | PFP; HPLH2; Perforin; perforin 1 (preforming protein); FLH2; cytolysin; lymphocyte pore forming protein; lym ...... |
Chromosomal Location | 10q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PRF1 in various data sets.
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Points in the above scatter plot represent the mutation difference of PRF1 in various data sets.
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Summary | |
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Symbol | PRF1 |
Name | perforin 1 (pore forming protein) |
Aliases | PFP; HPLH2; Perforin; perforin 1 (preforming protein); FLH2; cytolysin; lymphocyte pore forming protein; lym ...... |
Chromosomal Location | 10q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PRF1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PRF1 |
Name | perforin 1 (pore forming protein) |
Aliases | PFP; HPLH2; Perforin; perforin 1 (preforming protein); FLH2; cytolysin; lymphocyte pore forming protein; lym ...... |
Chromosomal Location | 10q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PRF1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PRF1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PRF1 |
Name | perforin 1 (pore forming protein) |
Aliases | PFP; HPLH2; Perforin; perforin 1 (preforming protein); FLH2; cytolysin; lymphocyte pore forming protein; lym ...... |
Chromosomal Location | 10q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PRF1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PRF1 |
Name | perforin 1 (pore forming protein) |
Aliases | PFP; HPLH2; Perforin; perforin 1 (preforming protein); FLH2; cytolysin; lymphocyte pore forming protein; lym ...... |
Chromosomal Location | 10q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PRF1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PRF1 |
Name | perforin 1 (pore forming protein) |
Aliases | PFP; HPLH2; Perforin; perforin 1 (preforming protein); FLH2; cytolysin; lymphocyte pore forming protein; lym ...... |
Chromosomal Location | 10q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PRF1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PRF1 |
Name | perforin 1 (pore forming protein) |
Aliases | PFP; HPLH2; Perforin; perforin 1 (preforming protein); FLH2; cytolysin; lymphocyte pore forming protein; lym ...... |
Chromosomal Location | 10q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PRF1 collected from DrugBank database. |
There is no record. |