Summary | |
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Symbol | PRG2 |
Name | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) |
Aliases | BMPG; bone-marrow proteoglycan; eosinophil granule major basic protein; eosinophil major basic protein; natu ...... |
Chromosomal Location | 11q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Bone marrow proteoglycan: Secreted. Note=The proform is secreted.; SUBCELLULAR LOCATION: Eosinophil granule major basic protein: Cytoplasmic vesicle, secretory vesicle. Note=The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core). |
Domain |
PF00059 Lectin C-type domain |
Function |
Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. |
Biological Process |
GO:0001818 negative regulation of cytokine production GO:0001819 positive regulation of cytokine production GO:0002215 defense response to nematode GO:0032613 interleukin-10 production GO:0032633 interleukin-4 production GO:0032653 regulation of interleukin-10 production GO:0032673 regulation of interleukin-4 production GO:0032693 negative regulation of interleukin-10 production GO:0032753 positive regulation of interleukin-4 production GO:0042035 regulation of cytokine biosynthetic process GO:0042089 cytokine biosynthetic process GO:0042107 cytokine metabolic process GO:0042742 defense response to bacterium GO:0098542 defense response to other organism |
Molecular Function |
GO:0005539 glycosaminoglycan binding GO:0008201 heparin binding GO:0030246 carbohydrate binding GO:1901681 sulfur compound binding |
Cellular Component |
GO:0030133 transport vesicle |
KEGG | - |
Reactome |
R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6798695: Neutrophil degranulation |
Summary | |
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Symbol | PRG2 |
Name | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) |
Aliases | BMPG; bone-marrow proteoglycan; eosinophil granule major basic protein; eosinophil major basic protein; natu ...... |
Chromosomal Location | 11q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PRG2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | PRG2 |
Name | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) |
Aliases | BMPG; bone-marrow proteoglycan; eosinophil granule major basic protein; eosinophil major basic protein; natu ...... |
Chromosomal Location | 11q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PRG2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PRG2 |
Name | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) |
Aliases | BMPG; bone-marrow proteoglycan; eosinophil granule major basic protein; eosinophil major basic protein; natu ...... |
Chromosomal Location | 11q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PRG2 in various data sets.
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Points in the above scatter plot represent the mutation difference of PRG2 in various data sets.
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Summary | |
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Symbol | PRG2 |
Name | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) |
Aliases | BMPG; bone-marrow proteoglycan; eosinophil granule major basic protein; eosinophil major basic protein; natu ...... |
Chromosomal Location | 11q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PRG2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PRG2 |
Name | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) |
Aliases | BMPG; bone-marrow proteoglycan; eosinophil granule major basic protein; eosinophil major basic protein; natu ...... |
Chromosomal Location | 11q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PRG2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PRG2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PRG2 |
Name | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) |
Aliases | BMPG; bone-marrow proteoglycan; eosinophil granule major basic protein; eosinophil major basic protein; natu ...... |
Chromosomal Location | 11q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PRG2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PRG2 |
Name | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) |
Aliases | BMPG; bone-marrow proteoglycan; eosinophil granule major basic protein; eosinophil major basic protein; natu ...... |
Chromosomal Location | 11q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PRG2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PRG2 |
Name | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) |
Aliases | BMPG; bone-marrow proteoglycan; eosinophil granule major basic protein; eosinophil major basic protein; natu ...... |
Chromosomal Location | 11q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PRG2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PRG2 |
Name | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) |
Aliases | BMPG; bone-marrow proteoglycan; eosinophil granule major basic protein; eosinophil major basic protein; natu ...... |
Chromosomal Location | 11q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PRG2 collected from DrugBank database. |
Details on drugs targeting PRG2.
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