Browse PRKAA1

Summary
SymbolPRKAA1
Nameprotein kinase, AMP-activated, alpha 1 catalytic subunit
Aliases AMPKa1; AMPK, alpha, 1; 5'-AMP-activated protein kinase, catalytic alpha-1 chain; AMP -activate kinase alpha ......
Chromosomal Location5p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Nucleus Note=In response to stress, recruited by p53/TP53 to specific promoters.
Domain PF16579 Adenylate sensor of SNF1-like protein kinase
PF00069 Protein kinase domain
Function

Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1. In response to nutrient limitation, phosphorylates transcription factor FOXO3 promoting FOXO3 mitochontrial import (By similarity). AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1.

> Gene Ontology
 
Biological Process GO:0000187 activation of MAPK activity
GO:0000302 response to reactive oxygen species
GO:0001666 response to hypoxia
GO:0005996 monosaccharide metabolic process
GO:0006006 glucose metabolic process
GO:0006066 alcohol metabolic process
GO:0006090 pyruvate metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0006096 glycolytic process
GO:0006109 regulation of carbohydrate metabolic process
GO:0006110 regulation of glycolytic process
GO:0006140 regulation of nucleotide metabolic process
GO:0006165 nucleoside diphosphate phosphorylation
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006643 membrane lipid metabolic process
GO:0006664 glycolipid metabolic process
GO:0006665 sphingolipid metabolic process
GO:0006672 ceramide metabolic process
GO:0006677 glycosylceramide metabolic process
GO:0006678 glucosylceramide metabolic process
GO:0006679 glucosylceramide biosynthetic process
GO:0006687 glycosphingolipid metabolic process
GO:0006688 glycosphingolipid biosynthetic process
GO:0006694 steroid biosynthetic process
GO:0006695 cholesterol biosynthetic process
GO:0006732 coenzyme metabolic process
GO:0006733 oxidoreduction coenzyme metabolic process
GO:0006757 ATP generation from ADP
GO:0006914 autophagy
GO:0006979 response to oxidative stress
GO:0007050 cell cycle arrest
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0007623 circadian rhythm
GO:0008202 steroid metabolic process
GO:0008203 cholesterol metabolic process
GO:0008643 carbohydrate transport
GO:0008645 hexose transport
GO:0009116 nucleoside metabolic process
GO:0009118 regulation of nucleoside metabolic process
GO:0009119 ribonucleoside metabolic process
GO:0009123 nucleoside monophosphate metabolic process
GO:0009126 purine nucleoside monophosphate metabolic process
GO:0009132 nucleoside diphosphate metabolic process
GO:0009135 purine nucleoside diphosphate metabolic process
GO:0009141 nucleoside triphosphate metabolic process
GO:0009144 purine nucleoside triphosphate metabolic process
GO:0009150 purine ribonucleotide metabolic process
GO:0009161 ribonucleoside monophosphate metabolic process
GO:0009167 purine ribonucleoside monophosphate metabolic process
GO:0009179 purine ribonucleoside diphosphate metabolic process
GO:0009185 ribonucleoside diphosphate metabolic process
GO:0009199 ribonucleoside triphosphate metabolic process
GO:0009205 purine ribonucleoside triphosphate metabolic process
GO:0009247 glycolipid biosynthetic process
GO:0009266 response to temperature stimulus
GO:0009267 cellular response to starvation
GO:0009314 response to radiation
GO:0009409 response to cold
GO:0009411 response to UV
GO:0009416 response to light stimulus
GO:0009631 cold acclimation
GO:0009894 regulation of catabolic process
GO:0009895 negative regulation of catabolic process
GO:0009896 positive regulation of catabolic process
GO:0009991 response to extracellular stimulus
GO:0010035 response to inorganic substance
GO:0010212 response to ionizing radiation
GO:0010332 response to gamma radiation
GO:0010506 regulation of autophagy
GO:0010508 positive regulation of autophagy
GO:0010827 regulation of glucose transport
GO:0010829 negative regulation of glucose transport
GO:0010893 positive regulation of steroid biosynthetic process
GO:0014074 response to purine-containing compound
GO:0014706 striated muscle tissue development
GO:0014823 response to activity
GO:0015749 monosaccharide transport
GO:0015758 glucose transport
GO:0016042 lipid catabolic process
GO:0016052 carbohydrate catabolic process
GO:0016053 organic acid biosynthetic process
GO:0016055 Wnt signaling pathway
GO:0016125 sterol metabolic process
GO:0016126 sterol biosynthetic process
GO:0016202 regulation of striated muscle tissue development
GO:0016236 macroautophagy
GO:0016570 histone modification
GO:0016572 histone phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0018209 peptidyl-serine modification
GO:0019216 regulation of lipid metabolic process
GO:0019218 regulation of steroid metabolic process
GO:0019318 hexose metabolic process
GO:0019362 pyridine nucleotide metabolic process
GO:0019395 fatty acid oxidation
GO:0019722 calcium-mediated signaling
GO:0019932 second-messenger-mediated signaling
GO:0030148 sphingolipid biosynthetic process
GO:0030258 lipid modification
GO:0031000 response to caffeine
GO:0031329 regulation of cellular catabolic process
GO:0031331 positive regulation of cellular catabolic process
GO:0031667 response to nutrient levels
GO:0031668 cellular response to extracellular stimulus
GO:0031669 cellular response to nutrient levels
GO:0031929 TOR signaling
GO:0032006 regulation of TOR signaling
GO:0032007 negative regulation of TOR signaling
GO:0032147 activation of protein kinase activity
GO:0032844 regulation of homeostatic process
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0033135 regulation of peptidyl-serine phosphorylation
GO:0033500 carbohydrate homeostasis
GO:0033674 positive regulation of kinase activity
GO:0034248 regulation of cellular amide metabolic process
GO:0034249 negative regulation of cellular amide metabolic process
GO:0034440 lipid oxidation
GO:0034599 cellular response to oxidative stress
GO:0034614 cellular response to reactive oxygen species
GO:0034694 response to prostaglandin
GO:0034695 response to prostaglandin E
GO:0035404 histone-serine phosphorylation
GO:0036293 response to decreased oxygen levels
GO:0036294 cellular response to decreased oxygen levels
GO:0042149 cellular response to glucose starvation
GO:0042278 purine nucleoside metabolic process
GO:0042542 response to hydrogen peroxide
GO:0042593 glucose homeostasis
GO:0042594 response to starvation
GO:0042752 regulation of circadian rhythm
GO:0043279 response to alkaloid
GO:0043405 regulation of MAP kinase activity
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043434 response to peptide hormone
GO:0043467 regulation of generation of precursor metabolites and energy
GO:0043470 regulation of carbohydrate catabolic process
GO:0044283 small molecule biosynthetic process
GO:0044381 glucose import in response to insulin stimulus
GO:0044723 single-organism carbohydrate metabolic process
GO:0044724 single-organism carbohydrate catabolic process
GO:0045471 response to ethanol
GO:0045540 regulation of cholesterol biosynthetic process
GO:0045542 positive regulation of cholesterol biosynthetic process
GO:0045786 negative regulation of cell cycle
GO:0045821 positive regulation of glycolytic process
GO:0045833 negative regulation of lipid metabolic process
GO:0045834 positive regulation of lipid metabolic process
GO:0045844 positive regulation of striated muscle tissue development
GO:0045860 positive regulation of protein kinase activity
GO:0045913 positive regulation of carbohydrate metabolic process
GO:0045940 positive regulation of steroid metabolic process
GO:0045979 positive regulation of nucleoside metabolic process
GO:0045981 positive regulation of nucleotide metabolic process
GO:0046031 ADP metabolic process
GO:0046034 ATP metabolic process
GO:0046128 purine ribonucleoside metabolic process
GO:0046165 alcohol biosynthetic process
GO:0046317 regulation of glucosylceramide biosynthetic process
GO:0046318 negative regulation of glucosylceramide biosynthetic process
GO:0046323 glucose import
GO:0046324 regulation of glucose import
GO:0046325 negative regulation of glucose import
GO:0046394 carboxylic acid biosynthetic process
GO:0046467 membrane lipid biosynthetic process
GO:0046476 glycosylceramide biosynthetic process
GO:0046496 nicotinamide nucleotide metabolic process
GO:0046513 ceramide biosynthetic process
GO:0046889 positive regulation of lipid biosynthetic process
GO:0046890 regulation of lipid biosynthetic process
GO:0046939 nucleotide phosphorylation
GO:0048511 rhythmic process
GO:0048634 regulation of muscle organ development
GO:0048636 positive regulation of muscle organ development
GO:0048641 regulation of skeletal muscle tissue development
GO:0048643 positive regulation of skeletal muscle tissue development
GO:0048871 multicellular organismal homeostasis
GO:0050810 regulation of steroid biosynthetic process
GO:0050994 regulation of lipid catabolic process
GO:0050995 negative regulation of lipid catabolic process
GO:0051051 negative regulation of transport
GO:0051055 negative regulation of lipid biosynthetic process
GO:0051186 cofactor metabolic process
GO:0051193 regulation of cofactor metabolic process
GO:0051194 positive regulation of cofactor metabolic process
GO:0051196 regulation of coenzyme metabolic process
GO:0051197 positive regulation of coenzyme metabolic process
GO:0051259 protein oligomerization
GO:0051291 protein heterooligomerization
GO:0055088 lipid homeostasis
GO:0055089 fatty acid homeostasis
GO:0060537 muscle tissue development
GO:0060538 skeletal muscle organ development
GO:0060627 regulation of vesicle-mediated transport
GO:0061762 CAMKK-AMPK signaling cascade
GO:0070301 cellular response to hydrogen peroxide
GO:0070482 response to oxygen levels
GO:0071361 cellular response to ethanol
GO:0071375 cellular response to peptide hormone stimulus
GO:0071379 cellular response to prostaglandin stimulus
GO:0071380 cellular response to prostaglandin E stimulus
GO:0071417 cellular response to organonitrogen compound
GO:0071453 cellular response to oxygen levels
GO:0071456 cellular response to hypoxia
GO:0071496 cellular response to external stimulus
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0072330 monocarboxylic acid biosynthetic process
GO:0072331 signal transduction by p53 class mediator
GO:0072524 pyridine-containing compound metabolic process
GO:0090153 regulation of sphingolipid biosynthetic process
GO:0090155 negative regulation of sphingolipid biosynthetic process
GO:0090181 regulation of cholesterol metabolic process
GO:0090205 positive regulation of cholesterol metabolic process
GO:0097009 energy homeostasis
GO:0097305 response to alcohol
GO:0097306 cellular response to alcohol
GO:0099004 calmodulin dependent kinase signaling pathway
GO:0198738 cell-cell signaling by wnt
GO:1900060 negative regulation of ceramide biosynthetic process
GO:1900076 regulation of cellular response to insulin stimulus
GO:1900077 negative regulation of cellular response to insulin stimulus
GO:1900542 regulation of purine nucleotide metabolic process
GO:1900544 positive regulation of purine nucleotide metabolic process
GO:1901563 response to camptothecin
GO:1901615 organic hydroxy compound metabolic process
GO:1901617 organic hydroxy compound biosynthetic process
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1901654 response to ketone
GO:1901655 cellular response to ketone
GO:1901657 glycosyl compound metabolic process
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1901861 regulation of muscle tissue development
GO:1901863 positive regulation of muscle tissue development
GO:1902532 negative regulation of intracellular signal transduction
GO:1902652 secondary alcohol metabolic process
GO:1902653 secondary alcohol biosynthetic process
GO:1902930 regulation of alcohol biosynthetic process
GO:1902932 positive regulation of alcohol biosynthetic process
GO:1903509 liposaccharide metabolic process
GO:1903578 regulation of ATP metabolic process
GO:1903580 positive regulation of ATP metabolic process
GO:1905038 regulation of membrane lipid metabolic process
GO:2000303 regulation of ceramide biosynthetic process
GO:2000505 regulation of energy homeostasis
GO:2001273 regulation of glucose import in response to insulin stimulus
GO:2001274 negative regulation of glucose import in response to insulin stimulus
Molecular Function GO:0003682 chromatin binding
GO:0004674 protein serine/threonine kinase activity
GO:0004679 AMP-activated protein kinase activity
GO:0004690 cyclic nucleotide-dependent protein kinase activity
GO:0004691 cAMP-dependent protein kinase activity
GO:0008022 protein C-terminus binding
GO:0035173 histone kinase activity
GO:0035174 histone serine kinase activity
GO:0047322 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
GO:0050321 tau-protein kinase activity
GO:0050405 [acetyl-CoA carboxylase] kinase activity
Cellular Component GO:0016324 apical plasma membrane
GO:0031588 nucleotide-activated protein kinase complex
GO:0045177 apical part of cell
GO:0061695 transferase complex, transferring phosphorus-containing groups
GO:1902911 protein kinase complex
> KEGG and Reactome Pathway
 
KEGG hsa04068 FoxO signaling pathway
hsa04140 Regulation of autophagy
hsa04150 mTOR signaling pathway
hsa04151 PI3K-Akt signaling pathway
hsa04152 AMPK signaling pathway
hsa04530 Tight junction
hsa04710 Circadian rhythm
hsa04910 Insulin signaling pathway
hsa04920 Adipocytokine signaling pathway
hsa04921 Oxytocin signaling pathway
hsa04922 Glucagon signaling pathway
Reactome R-HSA-2262752: Cellular responses to stress
R-HSA-380972: Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-2428924: IGF1R signaling cascade
R-HSA-112399: IRS-mediated signalling
R-HSA-2428928: IRS-related events triggered by IGF1R
R-HSA-74751: Insulin receptor signalling cascade
R-HSA-1632852: Macroautophagy
R-HSA-109704: PI3K Cascade
R-HSA-109703: PKB-mediated events
R-HSA-5633007: Regulation of TP53 Activity
R-HSA-6804756: Regulation of TP53 Activity through Phosphorylation
R-HSA-162582: Signal Transduction
R-HSA-74752: Signaling by Insulin receptor
R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-5628897: TP53 Regulates Metabolic Genes
R-HSA-3700989: Transcriptional Regulation by TP53
R-HSA-165159: mTOR signalling
Summary
SymbolPRKAA1
Nameprotein kinase, AMP-activated, alpha 1 catalytic subunit
Aliases AMPKa1; AMPK, alpha, 1; 5'-AMP-activated protein kinase, catalytic alpha-1 chain; AMP -activate kinase alpha ......
Chromosomal Location5p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PRKAA1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between PRKAA1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
25261236Breast CarcinomaInhibit immunityIn this study, we show that DCs isolated from patients with metastatic or locally advanced breast cancer express high levels of the adiponectin receptors AdipoR1 and AdipoR2, which are sufficient to blunt antitumor immunity. AdipoR1 stimulated IL10 production by activating the AMPK and MAPKp38 pathways, whereas AdipoR2 modified inflammatory processes by activating the COX-2 and PPARĪ³ pathways.
Summary
SymbolPRKAA1
Nameprotein kinase, AMP-activated, alpha 1 catalytic subunit
Aliases AMPKa1; AMPK, alpha, 1; 5'-AMP-activated protein kinase, catalytic alpha-1 chain; AMP -activate kinase alpha ......
Chromosomal Location5p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PRKAA1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPRKAA1
Nameprotein kinase, AMP-activated, alpha 1 catalytic subunit
Aliases AMPKa1; AMPK, alpha, 1; 5'-AMP-activated protein kinase, catalytic alpha-1 chain; AMP -activate kinase alpha ......
Chromosomal Location5p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PRKAA1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1280.701
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.2320.897
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0460.97
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0730.842
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1080.953
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.30.895
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1020.803
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0680.97
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1370.946
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.5630.669
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.2760.882
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0210.749
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PRKAA1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPRKAA1
Nameprotein kinase, AMP-activated, alpha 1 catalytic subunit
Aliases AMPKa1; AMPK, alpha, 1; 5'-AMP-activated protein kinase, catalytic alpha-1 chain; AMP -activate kinase alpha ......
Chromosomal Location5p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PRKAA1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPRKAA1
Nameprotein kinase, AMP-activated, alpha 1 catalytic subunit
Aliases AMPKa1; AMPK, alpha, 1; 5'-AMP-activated protein kinase, catalytic alpha-1 chain; AMP -activate kinase alpha ......
Chromosomal Location5p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PRKAA1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PRKAA1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPRKAA1
Nameprotein kinase, AMP-activated, alpha 1 catalytic subunit
Aliases AMPKa1; AMPK, alpha, 1; 5'-AMP-activated protein kinase, catalytic alpha-1 chain; AMP -activate kinase alpha ......
Chromosomal Location5p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PRKAA1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPRKAA1
Nameprotein kinase, AMP-activated, alpha 1 catalytic subunit
Aliases AMPKa1; AMPK, alpha, 1; 5'-AMP-activated protein kinase, catalytic alpha-1 chain; AMP -activate kinase alpha ......
Chromosomal Location5p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PRKAA1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPRKAA1
Nameprotein kinase, AMP-activated, alpha 1 catalytic subunit
Aliases AMPKa1; AMPK, alpha, 1; 5'-AMP-activated protein kinase, catalytic alpha-1 chain; AMP -activate kinase alpha ......
Chromosomal Location5p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PRKAA1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPRKAA1
Nameprotein kinase, AMP-activated, alpha 1 catalytic subunit
Aliases AMPKa1; AMPK, alpha, 1; 5'-AMP-activated protein kinase, catalytic alpha-1 chain; AMP -activate kinase alpha ......
Chromosomal Location5p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PRKAA1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting PRKAA1.
ID Name Drug Type Targets #Targets
DB00131Adenosine monophosphateSmall MoleculeACSL1, ACSS1, ACSS2, ADCY1, ADK, CREB1, FBP1, HINT1, PDE4B, PDE4D, ......15
DB00171ATPSmall MoleculeABCA1, ABCB1, ABCB11, ABCC1, ABCC2, ABCC4, ABCC6, ABCC8, ABCC9, AB ......42
DB00914PhenforminSmall MoleculeKCNJ8, PRKAA12
DB00945Acetylsalicylic acidSmall MoleculeAKR1C1, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, ......18