Summary | |
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Symbol | PRKAB2 |
Name | protein kinase, AMP-activated, beta 2 non-catalytic subunit |
Aliases | AMPK beta 2; 5'-AMP-activated protein kinase, beta-2 subunit; AMP-activated protein kinase beta 2 non-cataly ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF16561 Glycogen recognition site of AMP-activated protein kinase PF04739 5'-AMP-activated protein kinase beta subunit |
Function |
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). |
Biological Process |
GO:0006631 fatty acid metabolic process GO:0006633 fatty acid biosynthetic process GO:0006820 anion transport GO:0006839 mitochondrial transport GO:0006853 carnitine shuttle GO:0006869 lipid transport GO:0006914 autophagy GO:0007050 cell cycle arrest GO:0010565 regulation of cellular ketone metabolic process GO:0010876 lipid localization GO:0015711 organic anion transport GO:0015718 monocarboxylic acid transport GO:0015908 fatty acid transport GO:0015909 long-chain fatty acid transport GO:0016053 organic acid biosynthetic process GO:0016236 macroautophagy GO:0019216 regulation of lipid metabolic process GO:0019217 regulation of fatty acid metabolic process GO:0032365 intracellular lipid transport GO:0042180 cellular ketone metabolic process GO:0042304 regulation of fatty acid biosynthetic process GO:0044283 small molecule biosynthetic process GO:0045786 negative regulation of cell cycle GO:0046394 carboxylic acid biosynthetic process GO:0046890 regulation of lipid biosynthetic process GO:0046942 carboxylic acid transport GO:0072330 monocarboxylic acid biosynthetic process GO:0072331 signal transduction by p53 class mediator GO:0098656 anion transmembrane transport GO:1901796 regulation of signal transduction by p53 class mediator GO:1990542 mitochondrial transmembrane transport |
Molecular Function |
GO:0004674 protein serine/threonine kinase activity GO:0004679 AMP-activated protein kinase activity |
Cellular Component |
GO:0031588 nucleotide-activated protein kinase complex GO:0061695 transferase complex, transferring phosphorus-containing groups GO:1902911 protein kinase complex |
KEGG |
hsa04068 FoxO signaling pathway hsa04152 AMPK signaling pathway hsa04530 Tight junction hsa04710 Circadian rhythm hsa04910 Insulin signaling pathway hsa04920 Adipocytokine signaling pathway hsa04921 Oxytocin signaling pathway hsa04922 Glucagon signaling pathway |
Reactome |
R-HSA-163680: AMPK inhibits chREBP transcriptional activation activity R-HSA-2151209: Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2262752: Cellular responses to stress R-HSA-380972: Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-2428924: IGF1R signaling cascade R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-200425: Import of palmitoyl-CoA into the mitochondrial matrix R-HSA-74751: Insulin receptor signalling cascade R-HSA-163685: Integration of energy metabolism R-HSA-1632852: Macroautophagy R-HSA-199991: Membrane Trafficking R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-1592230: Mitochondrial biogenesis R-HSA-1852241: Organelle biogenesis and maintenance R-HSA-109704: PI3K Cascade R-HSA-109703: PKB-mediated events R-HSA-5633007: Regulation of TP53 Activity R-HSA-6804756: Regulation of TP53 Activity through Phosphorylation R-HSA-162582: Signal Transduction R-HSA-74752: Signaling by Insulin receptor R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-5628897: TP53 Regulates Metabolic Genes R-HSA-3700989: Transcriptional Regulation by TP53 R-HSA-1445148: Translocation of GLUT4 to the plasma membrane R-HSA-5653656: Vesicle-mediated transport R-HSA-165159: mTOR signalling |
Summary | |
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Symbol | PRKAB2 |
Name | protein kinase, AMP-activated, beta 2 non-catalytic subunit |
Aliases | AMPK beta 2; 5'-AMP-activated protein kinase, beta-2 subunit; AMP-activated protein kinase beta 2 non-cataly ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PRKAB2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | PRKAB2 |
Name | protein kinase, AMP-activated, beta 2 non-catalytic subunit |
Aliases | AMPK beta 2; 5'-AMP-activated protein kinase, beta-2 subunit; AMP-activated protein kinase beta 2 non-cataly ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PRKAB2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PRKAB2 |
Name | protein kinase, AMP-activated, beta 2 non-catalytic subunit |
Aliases | AMPK beta 2; 5'-AMP-activated protein kinase, beta-2 subunit; AMP-activated protein kinase beta 2 non-cataly ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PRKAB2 in various data sets.
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Points in the above scatter plot represent the mutation difference of PRKAB2 in various data sets.
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Summary | |
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Symbol | PRKAB2 |
Name | protein kinase, AMP-activated, beta 2 non-catalytic subunit |
Aliases | AMPK beta 2; 5'-AMP-activated protein kinase, beta-2 subunit; AMP-activated protein kinase beta 2 non-cataly ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PRKAB2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PRKAB2 |
Name | protein kinase, AMP-activated, beta 2 non-catalytic subunit |
Aliases | AMPK beta 2; 5'-AMP-activated protein kinase, beta-2 subunit; AMP-activated protein kinase beta 2 non-cataly ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PRKAB2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PRKAB2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PRKAB2 |
Name | protein kinase, AMP-activated, beta 2 non-catalytic subunit |
Aliases | AMPK beta 2; 5'-AMP-activated protein kinase, beta-2 subunit; AMP-activated protein kinase beta 2 non-cataly ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PRKAB2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PRKAB2 |
Name | protein kinase, AMP-activated, beta 2 non-catalytic subunit |
Aliases | AMPK beta 2; 5'-AMP-activated protein kinase, beta-2 subunit; AMP-activated protein kinase beta 2 non-cataly ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PRKAB2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PRKAB2 |
Name | protein kinase, AMP-activated, beta 2 non-catalytic subunit |
Aliases | AMPK beta 2; 5'-AMP-activated protein kinase, beta-2 subunit; AMP-activated protein kinase beta 2 non-cataly ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PRKAB2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PRKAB2 |
Name | protein kinase, AMP-activated, beta 2 non-catalytic subunit |
Aliases | AMPK beta 2; 5'-AMP-activated protein kinase, beta-2 subunit; AMP-activated protein kinase beta 2 non-cataly ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PRKAB2 collected from DrugBank database. |
Details on drugs targeting PRKAB2.
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