Summary | |
---|---|
Symbol | PRKACA |
Name | protein kinase, cAMP-dependent, catalytic, alpha |
Aliases | PKACa; PPNAD4; PKA C-alpha; cAMP-dependent protein kinase catalytic subunit alpha; protein kinase A catalyti ...... |
Chromosomal Location | 19p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Cell membrane. Nucleus Mitochondrion Membrane Lipid-anchor Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. Distributed throughout the cytoplasm in meiotically incompetent oocytes. Associated to mitochondrion as meiotic competence is acquired. Aggregates around the germinal vesicles (GV) at the immature GV stage oocytes (By similarity). Colocalizes with HSF1 in nuclear stress bodies (nSBs) upon heat shock (PubMed:21085490). ; SUBCELLULAR LOCATION: Isoform 2: Cell projection, cilium, flagellum Cytoplasmic vesicle, secretory vesicle, acrosome Note=Expressed in the midpiece region of the sperm flagellum (PubMed:10906071). Colocalizes with MROH2B and TCP11 on the acrosome and tail regions in round spermatids and spermatozoa regardless of the capacitation status of the sperm (By similarity). |
Domain |
PF00069 Protein kinase domain |
Function |
Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+). PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding. Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis. Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation. May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT). Phosphorylates APOBEC3G and AICDA. Isoform 2 phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock (PubMed:21085490). |
Biological Process |
GO:0000086 G2/M transition of mitotic cell cycle GO:0001503 ossification GO:0001649 osteoblast differentiation GO:0001678 cellular glucose homeostasis GO:0001704 formation of primary germ layer GO:0001707 mesoderm formation GO:0001838 embryonic epithelial tube formation GO:0001841 neural tube formation GO:0001843 neural tube closure GO:0002027 regulation of heart rate GO:0002218 activation of innate immune response GO:0002220 innate immune response activating cell surface receptor signaling pathway GO:0002223 stimulatory C-type lectin receptor signaling pathway GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002757 immune response-activating signal transduction GO:0002758 innate immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0003002 regionalization GO:0003012 muscle system process GO:0003013 circulatory system process GO:0003014 renal system process GO:0003015 heart process GO:0003091 renal water homeostasis GO:0006397 mRNA processing GO:0006611 protein export from nucleus GO:0006816 calcium ion transport GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0006913 nucleocytoplasmic transport GO:0006936 muscle contraction GO:0006937 regulation of muscle contraction GO:0006941 striated muscle contraction GO:0006942 regulation of striated muscle contraction GO:0007043 cell-cell junction assembly GO:0007050 cell cycle arrest GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007224 smoothened signaling pathway GO:0007281 germ cell development GO:0007283 spermatogenesis GO:0007286 spermatid development GO:0007369 gastrulation GO:0007389 pattern specification process GO:0007498 mesoderm development GO:0007596 blood coagulation GO:0007599 hemostasis GO:0008015 blood circulation GO:0008016 regulation of heart contraction GO:0008589 regulation of smoothened signaling pathway GO:0009743 response to carbohydrate GO:0009746 response to hexose GO:0009749 response to glucose GO:0009894 regulation of catabolic process GO:0009953 dorsal/ventral pattern formation GO:0010469 regulation of receptor activity GO:0010498 proteasomal protein catabolic process GO:0010522 regulation of calcium ion transport into cytosol GO:0010644 cell communication by electrical coupling GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling GO:0010959 regulation of metal ion transport GO:0014020 primary neural tube formation GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0016331 morphogenesis of embryonic epithelium GO:0016485 protein processing GO:0018105 peptidyl-serine phosphorylation GO:0018107 peptidyl-threonine phosphorylation GO:0018209 peptidyl-serine modification GO:0018210 peptidyl-threonine modification GO:0019722 calcium-mediated signaling GO:0019932 second-messenger-mediated signaling GO:0021532 neural tube patterning GO:0021700 developmental maturation GO:0021904 dorsal/ventral neural tube patterning GO:0021915 neural tube development GO:0022412 cellular process involved in reproduction in multicellular organism GO:0022898 regulation of transmembrane transporter activity GO:0030104 water homeostasis GO:0030278 regulation of ossification GO:0031329 regulation of cellular catabolic process GO:0031349 positive regulation of defense response GO:0032147 activation of protein kinase activity GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0032409 regulation of transporter activity GO:0032412 regulation of ion transmembrane transporter activity GO:0032844 regulation of homeostatic process GO:0032845 negative regulation of homeostatic process GO:0033157 regulation of intracellular protein transport GO:0033500 carbohydrate homeostasis GO:0033674 positive regulation of kinase activity GO:0033762 response to glucagon GO:0034199 activation of protein kinase A activity GO:0034284 response to monosaccharide GO:0034329 cell junction assembly GO:0034330 cell junction organization GO:0034762 regulation of transmembrane transport GO:0034765 regulation of ion transmembrane transport GO:0035148 tube formation GO:0035239 tube morphogenesis GO:0035584 calcium-mediated signaling using intracellular calcium source GO:0035637 multicellular organismal signaling GO:0042157 lipoprotein metabolic process GO:0042176 regulation of protein catabolic process GO:0042593 glucose homeostasis GO:0043297 apical junction assembly GO:0043393 regulation of protein binding GO:0043434 response to peptide hormone GO:0044057 regulation of system process GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044839 cell cycle G2/M phase transition GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045216 cell-cell junction organization GO:0045667 regulation of osteoblast differentiation GO:0045786 negative regulation of cell cycle GO:0045787 positive regulation of cell cycle GO:0045860 positive regulation of protein kinase activity GO:0045879 negative regulation of smoothened signaling pathway GO:0045992 negative regulation of embryonic development GO:0045995 regulation of embryonic development GO:0046777 protein autophosphorylation GO:0046822 regulation of nucleocytoplasmic transport GO:0046824 positive regulation of nucleocytoplasmic transport GO:0046825 regulation of protein export from nucleus GO:0046827 positive regulation of protein export from nucleus GO:0048232 male gamete generation GO:0048240 sperm capacitation GO:0048332 mesoderm morphogenesis GO:0048469 cell maturation GO:0048515 spermatid differentiation GO:0048871 multicellular organismal homeostasis GO:0050804 modulation of synaptic transmission GO:0050817 coagulation GO:0050848 regulation of calcium-mediated signaling GO:0050878 regulation of body fluid levels GO:0050891 multicellular organismal water homeostasis GO:0051098 regulation of binding GO:0051168 nuclear export GO:0051169 nuclear transport GO:0051208 sequestering of calcium ion GO:0051209 release of sequestered calcium ion into cytosol GO:0051222 positive regulation of protein transport GO:0051235 maintenance of location GO:0051238 sequestering of metal ion GO:0051279 regulation of release of sequestered calcium ion into cytosol GO:0051282 regulation of sequestering of calcium ion GO:0051283 negative regulation of sequestering of calcium ion GO:0051480 regulation of cytosolic calcium ion concentration GO:0051604 protein maturation GO:0051924 regulation of calcium ion transport GO:0051961 negative regulation of nervous system development GO:0055074 calcium ion homeostasis GO:0055117 regulation of cardiac muscle contraction GO:0060047 heart contraction GO:0060048 cardiac muscle contraction GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity GO:0060401 cytosolic calcium ion transport GO:0060402 calcium ion transport into cytosol GO:0060562 epithelial tube morphogenesis GO:0060606 tube closure GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning GO:0061136 regulation of proteasomal protein catabolic process GO:0061337 cardiac conduction GO:0070296 sarcoplasmic reticulum calcium ion transport GO:0070509 calcium ion import GO:0070588 calcium ion transmembrane transport GO:0070613 regulation of protein processing GO:0070830 bicellular tight junction assembly GO:0070838 divalent metal ion transport GO:0071107 response to parathyroid hormone GO:0071156 regulation of cell cycle arrest GO:0071158 positive regulation of cell cycle arrest GO:0071322 cellular response to carbohydrate stimulus GO:0071326 cellular response to monosaccharide stimulus GO:0071331 cellular response to hexose stimulus GO:0071333 cellular response to glucose stimulus GO:0071374 cellular response to parathyroid hormone stimulus GO:0071375 cellular response to peptide hormone stimulus GO:0071377 cellular response to glucagon stimulus GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071867 response to monoamine GO:0071868 cellular response to monoamine stimulus GO:0071869 response to catecholamine GO:0071870 cellular response to catecholamine stimulus GO:0071871 response to epinephrine GO:0071872 cellular response to epinephrine stimulus GO:0072175 epithelial tube formation GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072511 divalent inorganic cation transport GO:0086064 cell communication by electrical coupling involved in cardiac conduction GO:0086065 cell communication involved in cardiac conduction GO:0090068 positive regulation of cell cycle process GO:0090257 regulation of muscle system process GO:0090279 regulation of calcium ion import GO:0090316 positive regulation of intracellular protein transport GO:0097553 calcium ion transmembrane import into cytosol GO:1901019 regulation of calcium ion transmembrane transporter activity GO:1901620 regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1901888 regulation of cell junction assembly GO:1902656 calcium ion import into cytosol GO:1903050 regulation of proteolysis involved in cellular protein catabolic process GO:1903169 regulation of calcium ion transmembrane transport GO:1903317 regulation of protein maturation GO:1903362 regulation of cellular protein catabolic process GO:1903514 calcium ion transport from endoplasmic reticulum to cytosol GO:1903522 regulation of blood circulation GO:1903779 regulation of cardiac conduction GO:1903829 positive regulation of cellular protein localization GO:1904062 regulation of cation transmembrane transport GO:1904951 positive regulation of establishment of protein localization GO:2000021 regulation of ion homeostasis GO:2000810 regulation of bicellular tight junction assembly GO:2001257 regulation of cation channel activity |
Molecular Function |
GO:0004674 protein serine/threonine kinase activity GO:0004690 cyclic nucleotide-dependent protein kinase activity GO:0004691 cAMP-dependent protein kinase activity GO:0004712 protein serine/threonine/tyrosine kinase activity GO:0031625 ubiquitin protein ligase binding GO:0034237 protein kinase A regulatory subunit binding GO:0044389 ubiquitin-like protein ligase binding GO:0051018 protein kinase A binding |
Cellular Component |
GO:0005813 centrosome GO:0005929 cilium GO:0005952 cAMP-dependent protein kinase complex GO:0016604 nuclear body GO:0016607 nuclear speck GO:0031514 motile cilium GO:0031594 neuromuscular junction GO:0034702 ion channel complex GO:0034703 cation channel complex GO:0034704 calcium channel complex GO:0044441 ciliary part GO:0044853 plasma membrane raft GO:0045121 membrane raft GO:0061695 transferase complex, transferring phosphorus-containing groups GO:0097546 ciliary base GO:0098589 membrane region GO:0098857 membrane microdomain GO:1902495 transmembrane transporter complex GO:1902554 serine/threonine protein kinase complex GO:1902911 protein kinase complex GO:1990351 transporter complex |
KEGG |
hsa04010 MAPK signaling pathway hsa04014 Ras signaling pathway hsa04020 Calcium signaling pathway hsa04024 cAMP signaling pathway hsa04062 Chemokine signaling pathway hsa04114 Oocyte meiosis hsa04140 Regulation of autophagy hsa04261 Adrenergic signaling in cardiomyocytes hsa04270 Vascular smooth muscle contraction hsa04310 Wnt signaling pathway hsa04340 Hedgehog signaling pathway hsa04530 Tight junction hsa04540 Gap junction hsa04611 Platelet activation hsa04713 Circadian entrainment hsa04720 Long-term potentiation hsa04723 Retrograde endocannabinoid signaling hsa04724 Glutamatergic synapse hsa04725 Cholinergic synapse hsa04726 Serotonergic synapse hsa04727 GABAergic synapse hsa04728 Dopaminergic synapse hsa04740 Olfactory transduction hsa04742 Taste transduction hsa04750 Inflammatory mediator regulation of TRP channels hsa04910 Insulin signaling pathway hsa04911 Insulin secretion hsa04912 GnRH signaling pathway hsa04913 Ovarian steroidogenesis hsa04914 Progesterone-mediated oocyte maturation hsa04915 Estrogen signaling pathway hsa04916 Melanogenesis hsa04918 Thyroid hormone synthesis hsa04919 Thyroid hormone signaling pathway hsa04921 Oxytocin signaling pathway hsa04922 Glucagon signaling pathway hsa04961 Endocrine and other factor-regulated calcium reabsorption hsa04962 Vasopressin-regulated water reabsorption hsa04970 Salivary secretion hsa04971 Gastric acid secretion hsa04976 Bile secretion |
Reactome |
R-HSA-8854518: AURKA Activation by TPX2 R-HSA-442755: Activation of NMDA receptor upon glutamate binding and postsynaptic events R-HSA-1280218: Adaptive Immune System R-HSA-5620912: Anchoring of the basal body to the plasma membrane R-HSA-445717: Aquaporin-mediated transport R-HSA-422475: Axon guidance R-HSA-5621481: C-type lectin receptors (CLRs) R-HSA-5621575: CD209 (DC-SIGN) signaling R-HSA-442720: CREB phosphorylation through the activation of Adenylate Cyclase R-HSA-111996: Ca-dependent events R-HSA-111997: CaM pathway R-HSA-111933: Calmodulin induced events R-HSA-5576891: Cardiac conduction R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-380287: Centrosome maturation R-HSA-5617833: Cilium Assembly R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-1489509: DAG and IP3 signaling R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-180024: DARPP-32 events R-HSA-5610780: Degradation of GLI1 by the proteasome R-HSA-5610783: Degradation of GLI2 by the proteasome R-HSA-1266738: Developmental Biology R-HSA-186763: Downstream signal transduction R-HSA-212718: EGFR interacts with phospholipase C-gamma R-HSA-983231: Factors involved in megakaryocyte development and platelet production R-HSA-112040: G-protein mediated events R-HSA-69275: G2/M Transition R-HSA-5610785: GLI3 is processed to GLI3R by the proteasome R-HSA-163359: Glucagon signaling in metabolic regulation R-HSA-381676: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-70263: Gluconeogenesis R-HSA-70326: Glucose metabolism R-HSA-194223: HDL-mediated lipid transport R-HSA-5610787: Hedgehog 'off' state R-HSA-109582: Hemostasis R-HSA-163560: Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-163685: Integration of energy metabolism R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling R-HSA-5578775: Ion homeostasis R-HSA-73923: Lipid digestion, mobilization, and transport R-HSA-174824: Lipoprotein metabolism R-HSA-380259: Loss of Nlp from mitotic centrosomes R-HSA-380284: Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-5683057: MAPK family signaling cascades R-HSA-5687128: MAPK6/MAPK4 signaling R-HSA-1430728: Metabolism R-HSA-71387: Metabolism of carbohydrates R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-453274: Mitotic G2-G2/M phases R-HSA-397014: Muscle contraction R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-112316: Neuronal System R-HSA-112314: Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell R-HSA-111885: Opioid Signalling R-HSA-1852241: Organelle biogenesis and maintenance R-HSA-163615: PKA activation R-HSA-164378: PKA activation in glucagon signalling R-HSA-111931: PKA-mediated phosphorylation of CREB R-HSA-163358: PKA-mediated phosphorylation of key metabolic factors R-HSA-112043: PLC beta mediated events R-HSA-167021: PLC-gamma1 signalling R-HSA-438064: Post NMDA receptor activation events R-HSA-8853659: RET signaling R-HSA-392517: Rap1 signalling R-HSA-380270: Recruitment of mitotic centrosome proteins and complexes R-HSA-2565942: Regulation of PLK1 Activity at G2/M Transition R-HSA-422356: Regulation of insulin secretion R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-372790: Signaling by GPCR R-HSA-5358351: Signaling by Hedgehog R-HSA-449147: Signaling by Interleukins R-HSA-186797: Signaling by PDGF R-HSA-194138: Signaling by VEGF R-HSA-166520: Signalling by NGF R-HSA-382551: Transmembrane transport of small molecules R-HSA-112315: Transmission across Chemical Synapses R-HSA-4420097: VEGFA-VEGFR2 Pathway R-HSA-432040: Vasopressin regulates renal water homeostasis via Aquaporins |
Summary | |
---|---|
Symbol | PRKACA |
Name | protein kinase, cAMP-dependent, catalytic, alpha |
Aliases | PKACa; PPNAD4; PKA C-alpha; cAMP-dependent protein kinase catalytic subunit alpha; protein kinase A catalyti ...... |
Chromosomal Location | 19p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PRKACA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between PRKACA and anti-tumor immunity in human cancer.
|
Summary | |
---|---|
Symbol | PRKACA |
Name | protein kinase, cAMP-dependent, catalytic, alpha |
Aliases | PKACa; PPNAD4; PKA C-alpha; cAMP-dependent protein kinase catalytic subunit alpha; protein kinase A catalyti ...... |
Chromosomal Location | 19p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of PRKACA in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | PRKACA |
Name | protein kinase, cAMP-dependent, catalytic, alpha |
Aliases | PKACa; PPNAD4; PKA C-alpha; cAMP-dependent protein kinase catalytic subunit alpha; protein kinase A catalyti ...... |
Chromosomal Location | 19p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PRKACA in various data sets.
|
Points in the above scatter plot represent the mutation difference of PRKACA in various data sets.
|
Summary | |
---|---|
Symbol | PRKACA |
Name | protein kinase, cAMP-dependent, catalytic, alpha |
Aliases | PKACa; PPNAD4; PKA C-alpha; cAMP-dependent protein kinase catalytic subunit alpha; protein kinase A catalyti ...... |
Chromosomal Location | 19p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PRKACA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | PRKACA |
Name | protein kinase, cAMP-dependent, catalytic, alpha |
Aliases | PKACa; PPNAD4; PKA C-alpha; cAMP-dependent protein kinase catalytic subunit alpha; protein kinase A catalyti ...... |
Chromosomal Location | 19p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PRKACA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PRKACA. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | PRKACA |
Name | protein kinase, cAMP-dependent, catalytic, alpha |
Aliases | PKACa; PPNAD4; PKA C-alpha; cAMP-dependent protein kinase catalytic subunit alpha; protein kinase A catalyti ...... |
Chromosomal Location | 19p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PRKACA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | PRKACA |
Name | protein kinase, cAMP-dependent, catalytic, alpha |
Aliases | PKACa; PPNAD4; PKA C-alpha; cAMP-dependent protein kinase catalytic subunit alpha; protein kinase A catalyti ...... |
Chromosomal Location | 19p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PRKACA expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PRKACA |
Name | protein kinase, cAMP-dependent, catalytic, alpha |
Aliases | PKACa; PPNAD4; PKA C-alpha; cAMP-dependent protein kinase catalytic subunit alpha; protein kinase A catalyti ...... |
Chromosomal Location | 19p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PRKACA and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PRKACA |
Name | protein kinase, cAMP-dependent, catalytic, alpha |
Aliases | PKACa; PPNAD4; PKA C-alpha; cAMP-dependent protein kinase catalytic subunit alpha; protein kinase A catalyti ...... |
Chromosomal Location | 19p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PRKACA collected from DrugBank database. |
Details on drugs targeting PRKACA.
|