Browse PRKACA

Summary
SymbolPRKACA
Nameprotein kinase, cAMP-dependent, catalytic, alpha
Aliases PKACa; PPNAD4; PKA C-alpha; cAMP-dependent protein kinase catalytic subunit alpha; protein kinase A catalyti ......
Chromosomal Location19p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm. Cell membrane. Nucleus Mitochondrion Membrane Lipid-anchor Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. Distributed throughout the cytoplasm in meiotically incompetent oocytes. Associated to mitochondrion as meiotic competence is acquired. Aggregates around the germinal vesicles (GV) at the immature GV stage oocytes (By similarity). Colocalizes with HSF1 in nuclear stress bodies (nSBs) upon heat shock (PubMed:21085490). ; SUBCELLULAR LOCATION: Isoform 2: Cell projection, cilium, flagellum Cytoplasmic vesicle, secretory vesicle, acrosome Note=Expressed in the midpiece region of the sperm flagellum (PubMed:10906071). Colocalizes with MROH2B and TCP11 on the acrosome and tail regions in round spermatids and spermatozoa regardless of the capacitation status of the sperm (By similarity).
Domain PF00069 Protein kinase domain
Function

Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca(2+), leading to reduced amplitude and increased frequency of store overload-induced Ca(2+) release (SOICR) characterized by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+). PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding. Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis. Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation. May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT). Phosphorylates APOBEC3G and AICDA. Isoform 2 phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. Phosphorylates HSF1; this phosphorylation promotes HSF1 nuclear localization and transcriptional activity upon heat shock (PubMed:21085490).

> Gene Ontology
 
Biological Process GO:0000086 G2/M transition of mitotic cell cycle
GO:0001503 ossification
GO:0001649 osteoblast differentiation
GO:0001678 cellular glucose homeostasis
GO:0001704 formation of primary germ layer
GO:0001707 mesoderm formation
GO:0001838 embryonic epithelial tube formation
GO:0001841 neural tube formation
GO:0001843 neural tube closure
GO:0002027 regulation of heart rate
GO:0002218 activation of innate immune response
GO:0002220 innate immune response activating cell surface receptor signaling pathway
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002429 immune response-activating cell surface receptor signaling pathway
GO:0002757 immune response-activating signal transduction
GO:0002758 innate immune response-activating signal transduction
GO:0002764 immune response-regulating signaling pathway
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0003002 regionalization
GO:0003012 muscle system process
GO:0003013 circulatory system process
GO:0003014 renal system process
GO:0003015 heart process
GO:0003091 renal water homeostasis
GO:0006397 mRNA processing
GO:0006611 protein export from nucleus
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0006913 nucleocytoplasmic transport
GO:0006936 muscle contraction
GO:0006937 regulation of muscle contraction
GO:0006941 striated muscle contraction
GO:0006942 regulation of striated muscle contraction
GO:0007043 cell-cell junction assembly
GO:0007050 cell cycle arrest
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007224 smoothened signaling pathway
GO:0007281 germ cell development
GO:0007283 spermatogenesis
GO:0007286 spermatid development
GO:0007369 gastrulation
GO:0007389 pattern specification process
GO:0007498 mesoderm development
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0008015 blood circulation
GO:0008016 regulation of heart contraction
GO:0008589 regulation of smoothened signaling pathway
GO:0009743 response to carbohydrate
GO:0009746 response to hexose
GO:0009749 response to glucose
GO:0009894 regulation of catabolic process
GO:0009953 dorsal/ventral pattern formation
GO:0010469 regulation of receptor activity
GO:0010498 proteasomal protein catabolic process
GO:0010522 regulation of calcium ion transport into cytosol
GO:0010644 cell communication by electrical coupling
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
GO:0010959 regulation of metal ion transport
GO:0014020 primary neural tube formation
GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0016331 morphogenesis of embryonic epithelium
GO:0016485 protein processing
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0018209 peptidyl-serine modification
GO:0018210 peptidyl-threonine modification
GO:0019722 calcium-mediated signaling
GO:0019932 second-messenger-mediated signaling
GO:0021532 neural tube patterning
GO:0021700 developmental maturation
GO:0021904 dorsal/ventral neural tube patterning
GO:0021915 neural tube development
GO:0022412 cellular process involved in reproduction in multicellular organism
GO:0022898 regulation of transmembrane transporter activity
GO:0030104 water homeostasis
GO:0030278 regulation of ossification
GO:0031329 regulation of cellular catabolic process
GO:0031349 positive regulation of defense response
GO:0032147 activation of protein kinase activity
GO:0032386 regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0032409 regulation of transporter activity
GO:0032412 regulation of ion transmembrane transporter activity
GO:0032844 regulation of homeostatic process
GO:0032845 negative regulation of homeostatic process
GO:0033157 regulation of intracellular protein transport
GO:0033500 carbohydrate homeostasis
GO:0033674 positive regulation of kinase activity
GO:0033762 response to glucagon
GO:0034199 activation of protein kinase A activity
GO:0034284 response to monosaccharide
GO:0034329 cell junction assembly
GO:0034330 cell junction organization
GO:0034762 regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0035148 tube formation
GO:0035239 tube morphogenesis
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0035637 multicellular organismal signaling
GO:0042157 lipoprotein metabolic process
GO:0042176 regulation of protein catabolic process
GO:0042593 glucose homeostasis
GO:0043297 apical junction assembly
GO:0043393 regulation of protein binding
GO:0043434 response to peptide hormone
GO:0044057 regulation of system process
GO:0044770 cell cycle phase transition
GO:0044772 mitotic cell cycle phase transition
GO:0044839 cell cycle G2/M phase transition
GO:0045088 regulation of innate immune response
GO:0045089 positive regulation of innate immune response
GO:0045216 cell-cell junction organization
GO:0045667 regulation of osteoblast differentiation
GO:0045786 negative regulation of cell cycle
GO:0045787 positive regulation of cell cycle
GO:0045860 positive regulation of protein kinase activity
GO:0045879 negative regulation of smoothened signaling pathway
GO:0045992 negative regulation of embryonic development
GO:0045995 regulation of embryonic development
GO:0046777 protein autophosphorylation
GO:0046822 regulation of nucleocytoplasmic transport
GO:0046824 positive regulation of nucleocytoplasmic transport
GO:0046825 regulation of protein export from nucleus
GO:0046827 positive regulation of protein export from nucleus
GO:0048232 male gamete generation
GO:0048240 sperm capacitation
GO:0048332 mesoderm morphogenesis
GO:0048469 cell maturation
GO:0048515 spermatid differentiation
GO:0048871 multicellular organismal homeostasis
GO:0050804 modulation of synaptic transmission
GO:0050817 coagulation
GO:0050848 regulation of calcium-mediated signaling
GO:0050878 regulation of body fluid levels
GO:0050891 multicellular organismal water homeostasis
GO:0051098 regulation of binding
GO:0051168 nuclear export
GO:0051169 nuclear transport
GO:0051208 sequestering of calcium ion
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051222 positive regulation of protein transport
GO:0051235 maintenance of location
GO:0051238 sequestering of metal ion
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0051282 regulation of sequestering of calcium ion
GO:0051283 negative regulation of sequestering of calcium ion
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051604 protein maturation
GO:0051924 regulation of calcium ion transport
GO:0051961 negative regulation of nervous system development
GO:0055074 calcium ion homeostasis
GO:0055117 regulation of cardiac muscle contraction
GO:0060047 heart contraction
GO:0060048 cardiac muscle contraction
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0060401 cytosolic calcium ion transport
GO:0060402 calcium ion transport into cytosol
GO:0060562 epithelial tube morphogenesis
GO:0060606 tube closure
GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0061136 regulation of proteasomal protein catabolic process
GO:0061337 cardiac conduction
GO:0070296 sarcoplasmic reticulum calcium ion transport
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
GO:0070613 regulation of protein processing
GO:0070830 bicellular tight junction assembly
GO:0070838 divalent metal ion transport
GO:0071107 response to parathyroid hormone
GO:0071156 regulation of cell cycle arrest
GO:0071158 positive regulation of cell cycle arrest
GO:0071322 cellular response to carbohydrate stimulus
GO:0071326 cellular response to monosaccharide stimulus
GO:0071331 cellular response to hexose stimulus
GO:0071333 cellular response to glucose stimulus
GO:0071374 cellular response to parathyroid hormone stimulus
GO:0071375 cellular response to peptide hormone stimulus
GO:0071377 cellular response to glucagon stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071417 cellular response to organonitrogen compound
GO:0071867 response to monoamine
GO:0071868 cellular response to monoamine stimulus
GO:0071869 response to catecholamine
GO:0071870 cellular response to catecholamine stimulus
GO:0071871 response to epinephrine
GO:0071872 cellular response to epinephrine stimulus
GO:0072175 epithelial tube formation
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072511 divalent inorganic cation transport
GO:0086064 cell communication by electrical coupling involved in cardiac conduction
GO:0086065 cell communication involved in cardiac conduction
GO:0090068 positive regulation of cell cycle process
GO:0090257 regulation of muscle system process
GO:0090279 regulation of calcium ion import
GO:0090316 positive regulation of intracellular protein transport
GO:0097553 calcium ion transmembrane import into cytosol
GO:1901019 regulation of calcium ion transmembrane transporter activity
GO:1901620 regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1901888 regulation of cell junction assembly
GO:1902656 calcium ion import into cytosol
GO:1903050 regulation of proteolysis involved in cellular protein catabolic process
GO:1903169 regulation of calcium ion transmembrane transport
GO:1903317 regulation of protein maturation
GO:1903362 regulation of cellular protein catabolic process
GO:1903514 calcium ion transport from endoplasmic reticulum to cytosol
GO:1903522 regulation of blood circulation
GO:1903779 regulation of cardiac conduction
GO:1903829 positive regulation of cellular protein localization
GO:1904062 regulation of cation transmembrane transport
GO:1904951 positive regulation of establishment of protein localization
GO:2000021 regulation of ion homeostasis
GO:2000810 regulation of bicellular tight junction assembly
GO:2001257 regulation of cation channel activity
Molecular Function GO:0004674 protein serine/threonine kinase activity
GO:0004690 cyclic nucleotide-dependent protein kinase activity
GO:0004691 cAMP-dependent protein kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0031625 ubiquitin protein ligase binding
GO:0034237 protein kinase A regulatory subunit binding
GO:0044389 ubiquitin-like protein ligase binding
GO:0051018 protein kinase A binding
Cellular Component GO:0005813 centrosome
GO:0005929 cilium
GO:0005952 cAMP-dependent protein kinase complex
GO:0016604 nuclear body
GO:0016607 nuclear speck
GO:0031514 motile cilium
GO:0031594 neuromuscular junction
GO:0034702 ion channel complex
GO:0034703 cation channel complex
GO:0034704 calcium channel complex
GO:0044441 ciliary part
GO:0044853 plasma membrane raft
GO:0045121 membrane raft
GO:0061695 transferase complex, transferring phosphorus-containing groups
GO:0097546 ciliary base
GO:0098589 membrane region
GO:0098857 membrane microdomain
GO:1902495 transmembrane transporter complex
GO:1902554 serine/threonine protein kinase complex
GO:1902911 protein kinase complex
GO:1990351 transporter complex
> KEGG and Reactome Pathway
 
KEGG hsa04010 MAPK signaling pathway
hsa04014 Ras signaling pathway
hsa04020 Calcium signaling pathway
hsa04024 cAMP signaling pathway
hsa04062 Chemokine signaling pathway
hsa04114 Oocyte meiosis
hsa04140 Regulation of autophagy
hsa04261 Adrenergic signaling in cardiomyocytes
hsa04270 Vascular smooth muscle contraction
hsa04310 Wnt signaling pathway
hsa04340 Hedgehog signaling pathway
hsa04530 Tight junction
hsa04540 Gap junction
hsa04611 Platelet activation
hsa04713 Circadian entrainment
hsa04720 Long-term potentiation
hsa04723 Retrograde endocannabinoid signaling
hsa04724 Glutamatergic synapse
hsa04725 Cholinergic synapse
hsa04726 Serotonergic synapse
hsa04727 GABAergic synapse
hsa04728 Dopaminergic synapse
hsa04740 Olfactory transduction
hsa04742 Taste transduction
hsa04750 Inflammatory mediator regulation of TRP channels
hsa04910 Insulin signaling pathway
hsa04911 Insulin secretion
hsa04912 GnRH signaling pathway
hsa04913 Ovarian steroidogenesis
hsa04914 Progesterone-mediated oocyte maturation
hsa04915 Estrogen signaling pathway
hsa04916 Melanogenesis
hsa04918 Thyroid hormone synthesis
hsa04919 Thyroid hormone signaling pathway
hsa04921 Oxytocin signaling pathway
hsa04922 Glucagon signaling pathway
hsa04961 Endocrine and other factor-regulated calcium reabsorption
hsa04962 Vasopressin-regulated water reabsorption
hsa04970 Salivary secretion
hsa04971 Gastric acid secretion
hsa04976 Bile secretion
Reactome R-HSA-8854518: AURKA Activation by TPX2
R-HSA-442755: Activation of NMDA receptor upon glutamate binding and postsynaptic events
R-HSA-1280218: Adaptive Immune System
R-HSA-5620912: Anchoring of the basal body to the plasma membrane
R-HSA-445717: Aquaporin-mediated transport
R-HSA-422475: Axon guidance
R-HSA-5621481: C-type lectin receptors (CLRs)
R-HSA-5621575: CD209 (DC-SIGN) signaling
R-HSA-442720: CREB phosphorylation through the activation of Adenylate Cyclase
R-HSA-111996: Ca-dependent events
R-HSA-111997: CaM pathway
R-HSA-111933: Calmodulin induced events
R-HSA-5576891: Cardiac conduction
R-HSA-1640170: Cell Cycle
R-HSA-69278: Cell Cycle, Mitotic
R-HSA-380287: Centrosome maturation
R-HSA-5617833: Cilium Assembly
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-1489509: DAG and IP3 signaling
R-HSA-2172127: DAP12 interactions
R-HSA-2424491: DAP12 signaling
R-HSA-180024: DARPP-32 events
R-HSA-5610780: Degradation of GLI1 by the proteasome
R-HSA-5610783: Degradation of GLI2 by the proteasome
R-HSA-1266738: Developmental Biology
R-HSA-186763: Downstream signal transduction
R-HSA-212718: EGFR interacts with phospholipase C-gamma
R-HSA-983231: Factors involved in megakaryocyte development and platelet production
R-HSA-112040: G-protein mediated events
R-HSA-69275: G2/M Transition
R-HSA-5610785: GLI3 is processed to GLI3R by the proteasome
R-HSA-163359: Glucagon signaling in metabolic regulation
R-HSA-381676: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-70263: Gluconeogenesis
R-HSA-70326: Glucose metabolism
R-HSA-194223: HDL-mediated lipid transport
R-HSA-5610787: Hedgehog 'off' state
R-HSA-109582: Hemostasis
R-HSA-163560: Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-163685: Integration of energy metabolism
R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling
R-HSA-5578775: Ion homeostasis
R-HSA-73923: Lipid digestion, mobilization, and transport
R-HSA-174824: Lipoprotein metabolism
R-HSA-380259: Loss of Nlp from mitotic centrosomes
R-HSA-380284: Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-5683057: MAPK family signaling cascades
R-HSA-5687128: MAPK6/MAPK4 signaling
R-HSA-1430728: Metabolism
R-HSA-71387: Metabolism of carbohydrates
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-453274: Mitotic G2-G2/M phases
R-HSA-397014: Muscle contraction
R-HSA-187037: NGF signalling via TRKA from the plasma membrane
R-HSA-112316: Neuronal System
R-HSA-112314: Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
R-HSA-111885: Opioid Signalling
R-HSA-1852241: Organelle biogenesis and maintenance
R-HSA-163615: PKA activation
R-HSA-164378: PKA activation in glucagon signalling
R-HSA-111931: PKA-mediated phosphorylation of CREB
R-HSA-163358: PKA-mediated phosphorylation of key metabolic factors
R-HSA-112043: PLC beta mediated events
R-HSA-167021: PLC-gamma1 signalling
R-HSA-438064: Post NMDA receptor activation events
R-HSA-8853659: RET signaling
R-HSA-392517: Rap1 signalling
R-HSA-380270: Recruitment of mitotic centrosome proteins and complexes
R-HSA-2565942: Regulation of PLK1 Activity at G2/M Transition
R-HSA-422356: Regulation of insulin secretion
R-HSA-162582: Signal Transduction
R-HSA-177929: Signaling by EGFR
R-HSA-372790: Signaling by GPCR
R-HSA-5358351: Signaling by Hedgehog
R-HSA-449147: Signaling by Interleukins
R-HSA-186797: Signaling by PDGF
R-HSA-194138: Signaling by VEGF
R-HSA-166520: Signalling by NGF
R-HSA-382551: Transmembrane transport of small molecules
R-HSA-112315: Transmission across Chemical Synapses
R-HSA-4420097: VEGFA-VEGFR2 Pathway
R-HSA-432040: Vasopressin regulates renal water homeostasis via Aquaporins
Summary
SymbolPRKACA
Nameprotein kinase, cAMP-dependent, catalytic, alpha
Aliases PKACa; PPNAD4; PKA C-alpha; cAMP-dependent protein kinase catalytic subunit alpha; protein kinase A catalyti ......
Chromosomal Location19p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PRKACA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between PRKACA and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
27245613Cervical CarcinomaInhibit immunityPKA also stimulated the binding of the coactivator p300 to HIF-1α to enhance its transcriptional activity and counteracted the inhibitory effect of asparaginyl hydroxylation on the association of p300 with HIF-1α. Furthermore, increased cAMP concentrations enhanced the expression of HIF target genes encoding CD39 and CD73, which are enzymes that convert extracellular adenosine 5'-triphosphate to adenosine, a molecule that enhances tumor immunosuppression and reduces heart rate and contractility.
Summary
SymbolPRKACA
Nameprotein kinase, cAMP-dependent, catalytic, alpha
Aliases PKACa; PPNAD4; PKA C-alpha; cAMP-dependent protein kinase catalytic subunit alpha; protein kinase A catalyti ......
Chromosomal Location19p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PRKACA in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPRKACA
Nameprotein kinase, cAMP-dependent, catalytic, alpha
Aliases PKACa; PPNAD4; PKA C-alpha; cAMP-dependent protein kinase catalytic subunit alpha; protein kinase A catalyti ......
Chromosomal Location19p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PRKACA in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1680.413
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.5630.819
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.1220.945
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2510.48
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.0890.962
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.4580.851
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0530.887
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1190.946
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0050.998
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.5670.74
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.5270.529
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0730.238
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PRKACA in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.72.711
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.73.40.31
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPRKACA
Nameprotein kinase, cAMP-dependent, catalytic, alpha
Aliases PKACa; PPNAD4; PKA C-alpha; cAMP-dependent protein kinase catalytic subunit alpha; protein kinase A catalyti ......
Chromosomal Location19p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PRKACA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPRKACA
Nameprotein kinase, cAMP-dependent, catalytic, alpha
Aliases PKACa; PPNAD4; PKA C-alpha; cAMP-dependent protein kinase catalytic subunit alpha; protein kinase A catalyti ......
Chromosomal Location19p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PRKACA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PRKACA.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPRKACA
Nameprotein kinase, cAMP-dependent, catalytic, alpha
Aliases PKACa; PPNAD4; PKA C-alpha; cAMP-dependent protein kinase catalytic subunit alpha; protein kinase A catalyti ......
Chromosomal Location19p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PRKACA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPRKACA
Nameprotein kinase, cAMP-dependent, catalytic, alpha
Aliases PKACa; PPNAD4; PKA C-alpha; cAMP-dependent protein kinase catalytic subunit alpha; protein kinase A catalyti ......
Chromosomal Location19p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PRKACA expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPRKACA
Nameprotein kinase, cAMP-dependent, catalytic, alpha
Aliases PKACa; PPNAD4; PKA C-alpha; cAMP-dependent protein kinase catalytic subunit alpha; protein kinase A catalyti ......
Chromosomal Location19p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PRKACA and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPRKACA
Nameprotein kinase, cAMP-dependent, catalytic, alpha
Aliases PKACa; PPNAD4; PKA C-alpha; cAMP-dependent protein kinase catalytic subunit alpha; protein kinase A catalyti ......
Chromosomal Location19p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PRKACA collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting PRKACA.
ID Name Drug Type Targets #Targets
DB01919PentanalSmall MoleculePRKACA1
DB01940Balanol Analog 2Small MoleculePRKACA1
DB02155Balanol Analog 8Small MoleculePRKACA1
DB02482PhosphonothreonineSmall MoleculeAURKA, CDK7, MAPK1, MAPK12, PRKACA, PRKACB, PRKCQ, RHO, S100A119
DB02611Balanol Analog 1Small MoleculePRKACA1
DB033743,5-DiiodotyrosineSmall MoleculeIYD, PKIA, PRKACA, PRSS14
DB04098BalanolSmall MoleculePRKACA1
DB04522DexfosfoserineSmall MoleculeCFTR, KCNC4, PDPK1, PIM1, PRKACA, PRKCQ, PYGL, PYGM, REG1A, RHO, S ......13
DB04530S,S-(2-Hydroxyethyl)ThiocysteineSmall MoleculeARG1, CYTH2, PDE1B, PDE4B, PIM1, PRKACA, SERPINB5, SNX3, TYMS9
DB04707HydroxyfasudilSmall MoleculePKIA, PRKACA, ROCK13
DB06959(2S)-1-(3H-Indol-3-yl)-3-{[5-(6-isoquinolinyl)-3-pyridinyl]oxy}-2-propanamineSmall MoleculePKIA, PRKACA2
DB06977(2S)-1-{[5-(1H-Indazol-5-yl)-3-pyridinyl]oxy}-3-(7aH-indol-3-yl)-2-propanamineSmall MoleculePRKACA1
DB07107(1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINESmall MoleculePKIA, PRKACA2
DB07124(2S)-1-(6H-INDOL-3-YL)-3-{[5-(7H-PYRAZOLO[3,4-C]PYRIDIN-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINESmall MoleculePRKACA1
DB07204(1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINESmall MoleculePKIA, PRKACA2
DB07235N-[(1S)-2-AMINO-1-(2,4-DICHLOROBENZYL)ETHYL]-5-[2-(METHYLAMINO)PYRIMIDIN-4-YL]THIOPHENE-2-CARBOXAMIDESmall MoleculePRKACA1
DB074583-(1H-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl)ethyl]-1H-indol-3-yl}-1H-pyrrole-2,5-dioneSmall MoleculePRKACA1
DB07583(4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINESmall MoleculePKIA, PRKACA2
DB07854N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINESmall MoleculePKIA, PRKACA2
DB07855(S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINESmall MoleculePKIA, PRKACA2
DB078566-{4-[4-(4-CHLOROPHENYL)PIPERIDIN-4-YL]PHENYL}-9H-PURINESmall MoleculePKIA, PRKACA2
DB07857(2R)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamineSmall MoleculePKIA, PRKACA2
DB07858(2S)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamineSmall MoleculePKIA, PRKACA2
DB078594-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINESmall MoleculeAKT2, GSK3B, PKIA, PRKACA4
DB07860(2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINESmall MoleculePKIA, PRKACA2
DB07876(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINESmall MoleculePKIA, PRKACA, ROCK13
DB07947ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDESmall MoleculeAKT2, GSK3B, PKIA, PRKACA4
DB07995N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDESmall MoleculeGSG2, PKIA, PRKACA3
DB079965-(2-methylpiperazine-1-sulfonyl)isoquinolineSmall MoleculePKIA, PRKACA2
DB07997N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDESmall MoleculePKIA, PRKACA2
DB080702-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINESmall MoleculePKIA, PRKACA2
DB08073(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINESmall MoleculeAKT2, GSK3B, PKIA, PRKACA4
DB081133-pyridin-4-yl-1H-indazoleSmall MoleculePKIA, PRKACA2
DB081145-benzyl-1,3-thiazol-2-amineSmall MoleculePKIA, PRKACA2
DB081481-[4-(4-chlorophenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamineSmall MoleculePKIA, PRKACA2
DB081491-[4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamineSmall MoleculePKIA, PRKACA2
DB081504-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminiumSmall MoleculePKIA, PRKACA2
DB08162FasudilSmall MoleculePKIA, PRKACA, ROCK1, ROCK24
DB08231Myristic acidSmall MoleculeABL1, ARF1, ARF6, ECI2, FKBP1A, GM2A, GUCA1A, HNF4A, INS, LY96, NC ......20
DB08568(2S)-1-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}-3-PHENYLPROPAN-2-AMINESmall MoleculePKIA, PRKACA2
DB085693-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.] PYRAZOLESmall MoleculePKIA, PRKACA2
DB08756(R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDESmall MoleculePKIA, PRKACA, ROCK1, ROCK24
DB08846Ellagic AcidSmall MoleculeCA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1 ......17