Summary | |
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Symbol | PROC |
Name | protein C (inactivator of coagulation factors Va and VIIIa) |
Aliases | prepro-protein C; THPH3; THPH4; anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; ...... |
Chromosomal Location | 2q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted Golgi apparatus Endoplasmic reticulum |
Domain |
PF00008 EGF-like domain PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain PF00089 Trypsin |
Function |
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845). |
Biological Process |
GO:0001885 endothelial cell development GO:0002064 epithelial cell development GO:0003158 endothelium development GO:0006465 signal peptide processing GO:0006888 ER to Golgi vesicle-mediated transport GO:0007596 blood coagulation GO:0007599 hemostasis GO:0010720 positive regulation of cell development GO:0016485 protein processing GO:0017187 peptidyl-glutamic acid carboxylation GO:0018200 peptidyl-glutamic acid modification GO:0018214 protein carboxylation GO:0030193 regulation of blood coagulation GO:0030195 negative regulation of blood coagulation GO:0030856 regulation of epithelial cell differentiation GO:0030858 positive regulation of epithelial cell differentiation GO:0031348 negative regulation of defense response GO:0032102 negative regulation of response to external stimulus GO:0045446 endothelial cell differentiation GO:0045601 regulation of endothelial cell differentiation GO:0045603 positive regulation of endothelial cell differentiation GO:0048193 Golgi vesicle transport GO:0050727 regulation of inflammatory response GO:0050728 negative regulation of inflammatory response GO:0050817 coagulation GO:0050818 regulation of coagulation GO:0050819 negative regulation of coagulation GO:0050878 regulation of body fluid levels GO:0050900 leukocyte migration GO:0051604 protein maturation GO:0061028 establishment of endothelial barrier GO:0061041 regulation of wound healing GO:0061045 negative regulation of wound healing GO:1900046 regulation of hemostasis GO:1900047 negative regulation of hemostasis GO:1901550 regulation of endothelial cell development GO:1901552 positive regulation of endothelial cell development GO:1903034 regulation of response to wounding GO:1903035 negative regulation of response to wounding GO:1903140 regulation of establishment of endothelial barrier GO:1903142 positive regulation of establishment of endothelial barrier |
Molecular Function |
GO:0004175 endopeptidase activity GO:0004252 serine-type endopeptidase activity GO:0008236 serine-type peptidase activity GO:0017171 serine hydrolase activity |
Cellular Component |
GO:0005788 endoplasmic reticulum lumen GO:0005796 Golgi lumen |
KEGG |
hsa04610 Complement and coagulation cascades |
Reactome |
R-HSA-202733: Cell surface interactions at the vascular wall R-HSA-140875: Common Pathway of Fibrin Clot Formation R-HSA-140877: Formation of Fibrin Clot (Clotting Cascade) R-HSA-163841: Gamma carboxylation, hypusine formation and arylsulfatase activation R-HSA-159740: Gamma-carboxylation of protein precursors R-HSA-159854: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-109582: Hemostasis R-HSA-140837: Intrinsic Pathway of Fibrin Clot Formation R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-159782: Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-159763: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus |
Summary | |
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Symbol | PROC |
Name | protein C (inactivator of coagulation factors Va and VIIIa) |
Aliases | prepro-protein C; THPH3; THPH4; anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; ...... |
Chromosomal Location | 2q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PROC and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | PROC |
Name | protein C (inactivator of coagulation factors Va and VIIIa) |
Aliases | prepro-protein C; THPH3; THPH4; anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; ...... |
Chromosomal Location | 2q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PROC in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PROC |
Name | protein C (inactivator of coagulation factors Va and VIIIa) |
Aliases | prepro-protein C; THPH3; THPH4; anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; ...... |
Chromosomal Location | 2q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PROC in various data sets.
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Points in the above scatter plot represent the mutation difference of PROC in various data sets.
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Summary | |
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Symbol | PROC |
Name | protein C (inactivator of coagulation factors Va and VIIIa) |
Aliases | prepro-protein C; THPH3; THPH4; anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; ...... |
Chromosomal Location | 2q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PROC. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PROC |
Name | protein C (inactivator of coagulation factors Va and VIIIa) |
Aliases | prepro-protein C; THPH3; THPH4; anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; ...... |
Chromosomal Location | 2q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PROC. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PROC. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PROC |
Name | protein C (inactivator of coagulation factors Va and VIIIa) |
Aliases | prepro-protein C; THPH3; THPH4; anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; ...... |
Chromosomal Location | 2q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PROC. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PROC |
Name | protein C (inactivator of coagulation factors Va and VIIIa) |
Aliases | prepro-protein C; THPH3; THPH4; anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; ...... |
Chromosomal Location | 2q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PROC expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PROC |
Name | protein C (inactivator of coagulation factors Va and VIIIa) |
Aliases | prepro-protein C; THPH3; THPH4; anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; ...... |
Chromosomal Location | 2q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PROC and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PROC |
Name | protein C (inactivator of coagulation factors Va and VIIIa) |
Aliases | prepro-protein C; THPH3; THPH4; anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; ...... |
Chromosomal Location | 2q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PROC collected from DrugBank database. |
Details on drugs targeting PROC.
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