Browse PROC

Summary
SymbolPROC
Nameprotein C (inactivator of coagulation factors Va and VIIIa)
Aliases prepro-protein C; THPH3; THPH4; anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; ......
Chromosomal Location2q13-q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted Golgi apparatus Endoplasmic reticulum
Domain PF00008 EGF-like domain
PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
PF00089 Trypsin
Function

Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845).

> Gene Ontology
 
Biological Process GO:0001885 endothelial cell development
GO:0002064 epithelial cell development
GO:0003158 endothelium development
GO:0006465 signal peptide processing
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0010720 positive regulation of cell development
GO:0016485 protein processing
GO:0017187 peptidyl-glutamic acid carboxylation
GO:0018200 peptidyl-glutamic acid modification
GO:0018214 protein carboxylation
GO:0030193 regulation of blood coagulation
GO:0030195 negative regulation of blood coagulation
GO:0030856 regulation of epithelial cell differentiation
GO:0030858 positive regulation of epithelial cell differentiation
GO:0031348 negative regulation of defense response
GO:0032102 negative regulation of response to external stimulus
GO:0045446 endothelial cell differentiation
GO:0045601 regulation of endothelial cell differentiation
GO:0045603 positive regulation of endothelial cell differentiation
GO:0048193 Golgi vesicle transport
GO:0050727 regulation of inflammatory response
GO:0050728 negative regulation of inflammatory response
GO:0050817 coagulation
GO:0050818 regulation of coagulation
GO:0050819 negative regulation of coagulation
GO:0050878 regulation of body fluid levels
GO:0050900 leukocyte migration
GO:0051604 protein maturation
GO:0061028 establishment of endothelial barrier
GO:0061041 regulation of wound healing
GO:0061045 negative regulation of wound healing
GO:1900046 regulation of hemostasis
GO:1900047 negative regulation of hemostasis
GO:1901550 regulation of endothelial cell development
GO:1901552 positive regulation of endothelial cell development
GO:1903034 regulation of response to wounding
GO:1903035 negative regulation of response to wounding
GO:1903140 regulation of establishment of endothelial barrier
GO:1903142 positive regulation of establishment of endothelial barrier
Molecular Function GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0017171 serine hydrolase activity
Cellular Component GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
> KEGG and Reactome Pathway
 
KEGG hsa04610 Complement and coagulation cascades
Reactome R-HSA-202733: Cell surface interactions at the vascular wall
R-HSA-140875: Common Pathway of Fibrin Clot Formation
R-HSA-140877: Formation of Fibrin Clot (Clotting Cascade)
R-HSA-163841: Gamma carboxylation, hypusine formation and arylsulfatase activation
R-HSA-159740: Gamma-carboxylation of protein precursors
R-HSA-159854: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
R-HSA-109582: Hemostasis
R-HSA-140837: Intrinsic Pathway of Fibrin Clot Formation
R-HSA-392499: Metabolism of proteins
R-HSA-597592: Post-translational protein modification
R-HSA-159782: Removal of aminoterminal propeptides from gamma-carboxylated proteins
R-HSA-159763: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Summary
SymbolPROC
Nameprotein C (inactivator of coagulation factors Va and VIIIa)
Aliases prepro-protein C; THPH3; THPH4; anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; ......
Chromosomal Location2q13-q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PROC and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolPROC
Nameprotein C (inactivator of coagulation factors Va and VIIIa)
Aliases prepro-protein C; THPH3; THPH4; anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; ......
Chromosomal Location2q13-q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PROC in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPROC
Nameprotein C (inactivator of coagulation factors Va and VIIIa)
Aliases prepro-protein C; THPH3; THPH4; anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; ......
Chromosomal Location2q13-q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PROC in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.5830.243
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.060.942
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)871.060.135
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3140.458
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.2590.82
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.390.799
729033130MelanomaallAnti-PD-1 (nivolumab) 26231.2220.0984
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.3040.323
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.8110.489
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.0180.992
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.5660.471
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.6960.00875
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PROC in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.67.4-4.80.565
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.57.7-3.21
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolPROC
Nameprotein C (inactivator of coagulation factors Va and VIIIa)
Aliases prepro-protein C; THPH3; THPH4; anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; ......
Chromosomal Location2q13-q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PROC. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPROC
Nameprotein C (inactivator of coagulation factors Va and VIIIa)
Aliases prepro-protein C; THPH3; THPH4; anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; ......
Chromosomal Location2q13-q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PROC. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PROC.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPROC
Nameprotein C (inactivator of coagulation factors Va and VIIIa)
Aliases prepro-protein C; THPH3; THPH4; anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; ......
Chromosomal Location2q13-q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PROC. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPROC
Nameprotein C (inactivator of coagulation factors Va and VIIIa)
Aliases prepro-protein C; THPH3; THPH4; anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; ......
Chromosomal Location2q13-q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PROC expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPROC
Nameprotein C (inactivator of coagulation factors Va and VIIIa)
Aliases prepro-protein C; THPH3; THPH4; anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; ......
Chromosomal Location2q13-q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PROC and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPROC
Nameprotein C (inactivator of coagulation factors Va and VIIIa)
Aliases prepro-protein C; THPH3; THPH4; anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; ......
Chromosomal Location2q13-q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PROC collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting PROC.
ID Name Drug Type Targets #Targets
DB00170MenadioneSmall MoleculeBGLAP, F10, F2, F7, F9, GGCX, NQO1, NQO2, PROC, PROS1, PROZ, VKORC ......13
DB00464Sodium Tetradecyl SulfateSmall MoleculePROC, PROS12
DB09131Cupric ChlorideSmall MoleculeCSTB, PROC2
DB09332KappadioneSmall MoleculeF10, F2, F7, F9, GGCX, PROC, PROS17
DB13149Protein S humanBiotechF10, F5, PROC3