Summary | |
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Symbol | PROCR |
Name | protein C receptor, endothelial |
Aliases | EPCR; CCD41; CD201; CCCA; APC receptor; CD201 antigen; activated protein C receptor; cell cycle, centrosome- ...... |
Chromosomal Location | 20q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Domain |
PF16497 MHC-I family domain |
Function |
Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation. |
Biological Process |
GO:0007596 blood coagulation GO:0007599 hemostasis GO:0050817 coagulation GO:0050818 regulation of coagulation GO:0050819 negative regulation of coagulation GO:0050878 regulation of body fluid levels GO:0050900 leukocyte migration |
Molecular Function | - |
Cellular Component |
GO:0005813 centrosome GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0030055 cell-substrate junction |
KEGG |
hsa04610 Complement and coagulation cascades |
Reactome |
R-HSA-202733: Cell surface interactions at the vascular wall R-HSA-140875: Common Pathway of Fibrin Clot Formation R-HSA-140877: Formation of Fibrin Clot (Clotting Cascade) R-HSA-109582: Hemostasis |
Summary | |
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Symbol | PROCR |
Name | protein C receptor, endothelial |
Aliases | EPCR; CCD41; CD201; CCCA; APC receptor; CD201 antigen; activated protein C receptor; cell cycle, centrosome- ...... |
Chromosomal Location | 20q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PROCR and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | PROCR |
Name | protein C receptor, endothelial |
Aliases | EPCR; CCD41; CD201; CCCA; APC receptor; CD201 antigen; activated protein C receptor; cell cycle, centrosome- ...... |
Chromosomal Location | 20q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PROCR in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PROCR |
Name | protein C receptor, endothelial |
Aliases | EPCR; CCD41; CD201; CCCA; APC receptor; CD201 antigen; activated protein C receptor; cell cycle, centrosome- ...... |
Chromosomal Location | 20q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PROCR in various data sets.
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Points in the above scatter plot represent the mutation difference of PROCR in various data sets.
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Summary | |
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Symbol | PROCR |
Name | protein C receptor, endothelial |
Aliases | EPCR; CCD41; CD201; CCCA; APC receptor; CD201 antigen; activated protein C receptor; cell cycle, centrosome- ...... |
Chromosomal Location | 20q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PROCR. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PROCR |
Name | protein C receptor, endothelial |
Aliases | EPCR; CCD41; CD201; CCCA; APC receptor; CD201 antigen; activated protein C receptor; cell cycle, centrosome- ...... |
Chromosomal Location | 20q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PROCR. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PROCR. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PROCR |
Name | protein C receptor, endothelial |
Aliases | EPCR; CCD41; CD201; CCCA; APC receptor; CD201 antigen; activated protein C receptor; cell cycle, centrosome- ...... |
Chromosomal Location | 20q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PROCR. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PROCR |
Name | protein C receptor, endothelial |
Aliases | EPCR; CCD41; CD201; CCCA; APC receptor; CD201 antigen; activated protein C receptor; cell cycle, centrosome- ...... |
Chromosomal Location | 20q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PROCR expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PROCR |
Name | protein C receptor, endothelial |
Aliases | EPCR; CCD41; CD201; CCCA; APC receptor; CD201 antigen; activated protein C receptor; cell cycle, centrosome- ...... |
Chromosomal Location | 20q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PROCR and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PROCR |
Name | protein C receptor, endothelial |
Aliases | EPCR; CCD41; CD201; CCCA; APC receptor; CD201 antigen; activated protein C receptor; cell cycle, centrosome- ...... |
Chromosomal Location | 20q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PROCR collected from DrugBank database. |
Details on drugs targeting PROCR.
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