Summary | |
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Symbol | PROS1 |
Name | protein S (alpha) |
Aliases | PROS; PS21; PS22; PS23; PS24; PS25; THPH5; THPH6; protein Sa; vitamin K-dependent plasma protein S; Vitamin ...... |
Chromosomal Location | 3q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF00008 EGF-like domain PF07645 Calcium-binding EGF domain PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain PF00054 Laminin G domain PF02210 Laminin G domain |
Function |
Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis. |
Biological Process |
GO:0002526 acute inflammatory response GO:0002576 platelet degranulation GO:0002673 regulation of acute inflammatory response GO:0002697 regulation of immune effector process GO:0002920 regulation of humoral immune response GO:0006465 signal peptide processing GO:0006887 exocytosis GO:0006888 ER to Golgi vesicle-mediated transport GO:0006956 complement activation GO:0006959 humoral immune response GO:0007596 blood coagulation GO:0007599 hemostasis GO:0010466 negative regulation of peptidase activity GO:0010951 negative regulation of endopeptidase activity GO:0016485 protein processing GO:0017187 peptidyl-glutamic acid carboxylation GO:0018200 peptidyl-glutamic acid modification GO:0018214 protein carboxylation GO:0030193 regulation of blood coagulation GO:0030195 negative regulation of blood coagulation GO:0030449 regulation of complement activation GO:0032102 negative regulation of response to external stimulus GO:0042730 fibrinolysis GO:0045055 regulated exocytosis GO:0045861 negative regulation of proteolysis GO:0048193 Golgi vesicle transport GO:0050727 regulation of inflammatory response GO:0050817 coagulation GO:0050818 regulation of coagulation GO:0050819 negative regulation of coagulation GO:0050878 regulation of body fluid levels GO:0050900 leukocyte migration GO:0051346 negative regulation of hydrolase activity GO:0051604 protein maturation GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0061041 regulation of wound healing GO:0061045 negative regulation of wound healing GO:0070613 regulation of protein processing GO:0072376 protein activation cascade GO:1900046 regulation of hemostasis GO:1900047 negative regulation of hemostasis GO:1903034 regulation of response to wounding GO:1903035 negative regulation of response to wounding GO:1903317 regulation of protein maturation GO:2000257 regulation of protein activation cascade |
Molecular Function |
GO:0004857 enzyme inhibitor activity GO:0004866 endopeptidase inhibitor activity GO:0030414 peptidase inhibitor activity GO:0061134 peptidase regulator activity GO:0061135 endopeptidase regulator activity |
Cellular Component |
GO:0005796 Golgi lumen GO:0030141 secretory granule GO:0031091 platelet alpha granule GO:0031093 platelet alpha granule lumen GO:0031983 vesicle lumen GO:0034774 secretory granule lumen GO:0060205 cytoplasmic membrane-bounded vesicle lumen GO:0072562 blood microparticle GO:0099503 secretory vesicle |
KEGG |
hsa04610 Complement and coagulation cascades |
Reactome |
R-HSA-202733: Cell surface interactions at the vascular wall R-HSA-140875: Common Pathway of Fibrin Clot Formation R-HSA-166658: Complement cascade R-HSA-140877: Formation of Fibrin Clot (Clotting Cascade) R-HSA-163841: Gamma carboxylation, hypusine formation and arylsulfatase activation R-HSA-159740: Gamma-carboxylation of protein precursors R-HSA-159854: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-HSA-109582: Hemostasis R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-392499: Metabolism of proteins R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-114608: Platelet degranulation R-HSA-597592: Post-translational protein modification R-HSA-977606: Regulation of Complement cascade R-HSA-159782: Removal of aminoterminal propeptides from gamma-carboxylated proteins R-HSA-76005: Response to elevated platelet cytosolic Ca2+ R-HSA-159763: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus |
Summary | |
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Symbol | PROS1 |
Name | protein S (alpha) |
Aliases | PROS; PS21; PS22; PS23; PS24; PS25; THPH5; THPH6; protein Sa; vitamin K-dependent plasma protein S; Vitamin ...... |
Chromosomal Location | 3q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PROS1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between PROS1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | PROS1 |
Name | protein S (alpha) |
Aliases | PROS; PS21; PS22; PS23; PS24; PS25; THPH5; THPH6; protein Sa; vitamin K-dependent plasma protein S; Vitamin ...... |
Chromosomal Location | 3q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PROS1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PROS1 |
Name | protein S (alpha) |
Aliases | PROS; PS21; PS22; PS23; PS24; PS25; THPH5; THPH6; protein Sa; vitamin K-dependent plasma protein S; Vitamin ...... |
Chromosomal Location | 3q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PROS1 in various data sets.
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Points in the above scatter plot represent the mutation difference of PROS1 in various data sets.
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Summary | |
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Symbol | PROS1 |
Name | protein S (alpha) |
Aliases | PROS; PS21; PS22; PS23; PS24; PS25; THPH5; THPH6; protein Sa; vitamin K-dependent plasma protein S; Vitamin ...... |
Chromosomal Location | 3q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PROS1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PROS1 |
Name | protein S (alpha) |
Aliases | PROS; PS21; PS22; PS23; PS24; PS25; THPH5; THPH6; protein Sa; vitamin K-dependent plasma protein S; Vitamin ...... |
Chromosomal Location | 3q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PROS1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PROS1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PROS1 |
Name | protein S (alpha) |
Aliases | PROS; PS21; PS22; PS23; PS24; PS25; THPH5; THPH6; protein Sa; vitamin K-dependent plasma protein S; Vitamin ...... |
Chromosomal Location | 3q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PROS1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PROS1 |
Name | protein S (alpha) |
Aliases | PROS; PS21; PS22; PS23; PS24; PS25; THPH5; THPH6; protein Sa; vitamin K-dependent plasma protein S; Vitamin ...... |
Chromosomal Location | 3q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PROS1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PROS1 |
Name | protein S (alpha) |
Aliases | PROS; PS21; PS22; PS23; PS24; PS25; THPH5; THPH6; protein Sa; vitamin K-dependent plasma protein S; Vitamin ...... |
Chromosomal Location | 3q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PROS1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PROS1 |
Name | protein S (alpha) |
Aliases | PROS; PS21; PS22; PS23; PS24; PS25; THPH5; THPH6; protein Sa; vitamin K-dependent plasma protein S; Vitamin ...... |
Chromosomal Location | 3q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PROS1 collected from DrugBank database. |
Details on drugs targeting PROS1.
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