Browse PRPF40A

Summary
SymbolPRPF40A
NamePRP40 pre-mRNA processing factor 40 homolog A
Aliases FLJ20585; FBP11; HYPA; NY-REN-6; HIP10; FBP-11; FLAF1; Prp40; FNBP3; formin-binding protein 3; formin bindin ......
Chromosomal Location2q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus speckle Nucleus matrix Note=Colocalizes with AKAP8L in the nuclear matrix.
Domain PF01846 FF domain
PF00397 WW domain
Function

Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing.

> Gene Ontology
 
Biological Process GO:0000375 RNA splicing, via transesterification reactions
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
GO:0000398 mRNA splicing, via spliceosome
GO:0000910 cytokinesis
GO:0006397 mRNA processing
GO:0008360 regulation of cell shape
GO:0008380 RNA splicing
GO:0022604 regulation of cell morphogenesis
GO:0032465 regulation of cytokinesis
GO:0051302 regulation of cell division
Molecular Function GO:0070064 proline-rich region binding
Cellular Component GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005685 U1 snRNP
GO:0016363 nuclear matrix
GO:0016604 nuclear body
GO:0016607 nuclear speck
GO:0030532 small nuclear ribonucleoprotein complex
GO:0034399 nuclear periphery
GO:0071004 U2-type prespliceosome
GO:0071010 prespliceosome
GO:0097525 spliceosomal snRNP complex
> KEGG and Reactome Pathway
 
KEGG hsa03040 Spliceosome
Reactome R-HSA-74160: Gene Expression
R-HSA-72203: Processing of Capped Intron-Containing Pre-mRNA
R-HSA-72172: mRNA Splicing
R-HSA-72163: mRNA Splicing - Major Pathway
Summary
SymbolPRPF40A
NamePRP40 pre-mRNA processing factor 40 homolog A
Aliases FLJ20585; FBP11; HYPA; NY-REN-6; HIP10; FBP-11; FLAF1; Prp40; FNBP3; formin-binding protein 3; formin bindin ......
Chromosomal Location2q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PRPF40A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolPRPF40A
NamePRP40 pre-mRNA processing factor 40 homolog A
Aliases FLJ20585; FBP11; HYPA; NY-REN-6; HIP10; FBP-11; FLAF1; Prp40; FNBP3; formin-binding protein 3; formin bindin ......
Chromosomal Location2q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PRPF40A in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.83 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolPRPF40A
NamePRP40 pre-mRNA processing factor 40 homolog A
Aliases FLJ20585; FBP11; HYPA; NY-REN-6; HIP10; FBP-11; FLAF1; Prp40; FNBP3; formin-binding protein 3; formin bindin ......
Chromosomal Location2q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PRPF40A in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0650.762
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.060.974
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.160.911
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0370.884
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1710.931
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1330.958
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0210.962
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0550.978
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1070.961
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.6290.639
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.7580.721
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0390.452
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PRPF40A in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 414250250.222
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)2117011.8-11.80.193
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)1311018.2-18.20.199
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPRPF40A
NamePRP40 pre-mRNA processing factor 40 homolog A
Aliases FLJ20585; FBP11; HYPA; NY-REN-6; HIP10; FBP-11; FLAF1; Prp40; FNBP3; formin-binding protein 3; formin bindin ......
Chromosomal Location2q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PRPF40A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPRPF40A
NamePRP40 pre-mRNA processing factor 40 homolog A
Aliases FLJ20585; FBP11; HYPA; NY-REN-6; HIP10; FBP-11; FLAF1; Prp40; FNBP3; formin-binding protein 3; formin bindin ......
Chromosomal Location2q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PRPF40A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PRPF40A.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPRPF40A
NamePRP40 pre-mRNA processing factor 40 homolog A
Aliases FLJ20585; FBP11; HYPA; NY-REN-6; HIP10; FBP-11; FLAF1; Prp40; FNBP3; formin-binding protein 3; formin bindin ......
Chromosomal Location2q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PRPF40A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPRPF40A
NamePRP40 pre-mRNA processing factor 40 homolog A
Aliases FLJ20585; FBP11; HYPA; NY-REN-6; HIP10; FBP-11; FLAF1; Prp40; FNBP3; formin-binding protein 3; formin bindin ......
Chromosomal Location2q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PRPF40A expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPRPF40A
NamePRP40 pre-mRNA processing factor 40 homolog A
Aliases FLJ20585; FBP11; HYPA; NY-REN-6; HIP10; FBP-11; FLAF1; Prp40; FNBP3; formin-binding protein 3; formin bindin ......
Chromosomal Location2q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PRPF40A and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPRPF40A
NamePRP40 pre-mRNA processing factor 40 homolog A
Aliases FLJ20585; FBP11; HYPA; NY-REN-6; HIP10; FBP-11; FLAF1; Prp40; FNBP3; formin-binding protein 3; formin bindin ......
Chromosomal Location2q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PRPF40A collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.