Summary | |
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Symbol | PRPF40A |
Name | PRP40 pre-mRNA processing factor 40 homolog A |
Aliases | FLJ20585; FBP11; HYPA; NY-REN-6; HIP10; FBP-11; FLAF1; Prp40; FNBP3; formin-binding protein 3; formin bindin ...... |
Chromosomal Location | 2q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus speckle Nucleus matrix Note=Colocalizes with AKAP8L in the nuclear matrix. |
Domain |
PF01846 FF domain PF00397 WW domain |
Function |
Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing. |
Biological Process |
GO:0000375 RNA splicing, via transesterification reactions GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile GO:0000398 mRNA splicing, via spliceosome GO:0000910 cytokinesis GO:0006397 mRNA processing GO:0008360 regulation of cell shape GO:0008380 RNA splicing GO:0022604 regulation of cell morphogenesis GO:0032465 regulation of cytokinesis GO:0051302 regulation of cell division |
Molecular Function |
GO:0070064 proline-rich region binding |
Cellular Component |
GO:0005681 spliceosomal complex GO:0005684 U2-type spliceosomal complex GO:0005685 U1 snRNP GO:0016363 nuclear matrix GO:0016604 nuclear body GO:0016607 nuclear speck GO:0030532 small nuclear ribonucleoprotein complex GO:0034399 nuclear periphery GO:0071004 U2-type prespliceosome GO:0071010 prespliceosome GO:0097525 spliceosomal snRNP complex |
KEGG |
hsa03040 Spliceosome |
Reactome |
R-HSA-74160: Gene Expression R-HSA-72203: Processing of Capped Intron-Containing Pre-mRNA R-HSA-72172: mRNA Splicing R-HSA-72163: mRNA Splicing - Major Pathway |
Summary | |
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Symbol | PRPF40A |
Name | PRP40 pre-mRNA processing factor 40 homolog A |
Aliases | FLJ20585; FBP11; HYPA; NY-REN-6; HIP10; FBP-11; FLAF1; Prp40; FNBP3; formin-binding protein 3; formin bindin ...... |
Chromosomal Location | 2q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PRPF40A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | PRPF40A |
Name | PRP40 pre-mRNA processing factor 40 homolog A |
Aliases | FLJ20585; FBP11; HYPA; NY-REN-6; HIP10; FBP-11; FLAF1; Prp40; FNBP3; formin-binding protein 3; formin bindin ...... |
Chromosomal Location | 2q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PRPF40A in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PRPF40A |
Name | PRP40 pre-mRNA processing factor 40 homolog A |
Aliases | FLJ20585; FBP11; HYPA; NY-REN-6; HIP10; FBP-11; FLAF1; Prp40; FNBP3; formin-binding protein 3; formin bindin ...... |
Chromosomal Location | 2q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PRPF40A in various data sets.
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Points in the above scatter plot represent the mutation difference of PRPF40A in various data sets.
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Summary | |
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Symbol | PRPF40A |
Name | PRP40 pre-mRNA processing factor 40 homolog A |
Aliases | FLJ20585; FBP11; HYPA; NY-REN-6; HIP10; FBP-11; FLAF1; Prp40; FNBP3; formin-binding protein 3; formin bindin ...... |
Chromosomal Location | 2q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PRPF40A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PRPF40A |
Name | PRP40 pre-mRNA processing factor 40 homolog A |
Aliases | FLJ20585; FBP11; HYPA; NY-REN-6; HIP10; FBP-11; FLAF1; Prp40; FNBP3; formin-binding protein 3; formin bindin ...... |
Chromosomal Location | 2q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PRPF40A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PRPF40A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PRPF40A |
Name | PRP40 pre-mRNA processing factor 40 homolog A |
Aliases | FLJ20585; FBP11; HYPA; NY-REN-6; HIP10; FBP-11; FLAF1; Prp40; FNBP3; formin-binding protein 3; formin bindin ...... |
Chromosomal Location | 2q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PRPF40A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PRPF40A |
Name | PRP40 pre-mRNA processing factor 40 homolog A |
Aliases | FLJ20585; FBP11; HYPA; NY-REN-6; HIP10; FBP-11; FLAF1; Prp40; FNBP3; formin-binding protein 3; formin bindin ...... |
Chromosomal Location | 2q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PRPF40A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PRPF40A |
Name | PRP40 pre-mRNA processing factor 40 homolog A |
Aliases | FLJ20585; FBP11; HYPA; NY-REN-6; HIP10; FBP-11; FLAF1; Prp40; FNBP3; formin-binding protein 3; formin bindin ...... |
Chromosomal Location | 2q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PRPF40A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PRPF40A |
Name | PRP40 pre-mRNA processing factor 40 homolog A |
Aliases | FLJ20585; FBP11; HYPA; NY-REN-6; HIP10; FBP-11; FLAF1; Prp40; FNBP3; formin-binding protein 3; formin bindin ...... |
Chromosomal Location | 2q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PRPF40A collected from DrugBank database. |
There is no record. |