Summary | |
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Symbol | PRRT2 |
Name | proline-rich transmembrane protein 2 |
Aliases | FLJ25513; DKFZp547J199; IFITMD1; FICCA; DSPB3; PKC; EKD1; interferon induced transmembrane protein domain co ...... |
Chromosomal Location | 16p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Cell junction, synapse, presynaptic cell membrane Cell junction, synapse Cell projection, axon Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Cell junction, synapse, postsynaptic cell membrane, postsynaptic density Cell projection, dendritic spine |
Domain |
PF04505 Interferon-induced transmembrane protein |
Function |
As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and downregulate short-term facilitation. |
Biological Process |
GO:0050884 neuromuscular process controlling posture GO:0050905 neuromuscular process |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | PRRT2 |
Name | proline-rich transmembrane protein 2 |
Aliases | FLJ25513; DKFZp547J199; IFITMD1; FICCA; DSPB3; PKC; EKD1; interferon induced transmembrane protein domain co ...... |
Chromosomal Location | 16p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PRRT2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PRRT2 |
Name | proline-rich transmembrane protein 2 |
Aliases | FLJ25513; DKFZp547J199; IFITMD1; FICCA; DSPB3; PKC; EKD1; interferon induced transmembrane protein domain co ...... |
Chromosomal Location | 16p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PRRT2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PRRT2 |
Name | proline-rich transmembrane protein 2 |
Aliases | FLJ25513; DKFZp547J199; IFITMD1; FICCA; DSPB3; PKC; EKD1; interferon induced transmembrane protein domain co ...... |
Chromosomal Location | 16p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PRRT2 in various data sets.
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Points in the above scatter plot represent the mutation difference of PRRT2 in various data sets.
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Summary | |
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Symbol | PRRT2 |
Name | proline-rich transmembrane protein 2 |
Aliases | FLJ25513; DKFZp547J199; IFITMD1; FICCA; DSPB3; PKC; EKD1; interferon induced transmembrane protein domain co ...... |
Chromosomal Location | 16p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PRRT2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PRRT2 |
Name | proline-rich transmembrane protein 2 |
Aliases | FLJ25513; DKFZp547J199; IFITMD1; FICCA; DSPB3; PKC; EKD1; interferon induced transmembrane protein domain co ...... |
Chromosomal Location | 16p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PRRT2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PRRT2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PRRT2 |
Name | proline-rich transmembrane protein 2 |
Aliases | FLJ25513; DKFZp547J199; IFITMD1; FICCA; DSPB3; PKC; EKD1; interferon induced transmembrane protein domain co ...... |
Chromosomal Location | 16p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PRRT2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PRRT2 |
Name | proline-rich transmembrane protein 2 |
Aliases | FLJ25513; DKFZp547J199; IFITMD1; FICCA; DSPB3; PKC; EKD1; interferon induced transmembrane protein domain co ...... |
Chromosomal Location | 16p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PRRT2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PRRT2 |
Name | proline-rich transmembrane protein 2 |
Aliases | FLJ25513; DKFZp547J199; IFITMD1; FICCA; DSPB3; PKC; EKD1; interferon induced transmembrane protein domain co ...... |
Chromosomal Location | 16p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PRRT2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PRRT2 |
Name | proline-rich transmembrane protein 2 |
Aliases | FLJ25513; DKFZp547J199; IFITMD1; FICCA; DSPB3; PKC; EKD1; interferon induced transmembrane protein domain co ...... |
Chromosomal Location | 16p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PRRT2 collected from DrugBank database. |
There is no record. |