Summary | |
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Symbol | PRRX1 |
Name | paired related homeobox 1 |
Aliases | PHOX1; PMX1; paired mesoderm homeo box 1; AGOTC; PRX-1; homeobox protein PHOX1; paired mesoderm homeobox 1 i ...... |
Chromosomal Location | 1q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. |
Domain |
PF00046 Homeobox domain PF03826 OAR domain |
Function |
Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity). |
Biological Process |
GO:0001501 skeletal system development GO:0001709 cell fate determination GO:0002053 positive regulation of mesenchymal cell proliferation GO:0007224 smoothened signaling pathway GO:0007423 sensory organ development GO:0008589 regulation of smoothened signaling pathway GO:0010463 mesenchymal cell proliferation GO:0010464 regulation of mesenchymal cell proliferation GO:0010975 regulation of neuron projection development GO:0019827 stem cell population maintenance GO:0030326 embryonic limb morphogenesis GO:0031099 regeneration GO:0031102 neuron projection regeneration GO:0035107 appendage morphogenesis GO:0035108 limb morphogenesis GO:0035113 embryonic appendage morphogenesis GO:0042471 ear morphogenesis GO:0042472 inner ear morphogenesis GO:0042474 middle ear morphogenesis GO:0043583 ear development GO:0045165 cell fate commitment GO:0045880 positive regulation of smoothened signaling pathway GO:0048514 blood vessel morphogenesis GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048663 neuron fate commitment GO:0048664 neuron fate determination GO:0048701 embryonic cranial skeleton morphogenesis GO:0048704 embryonic skeletal system morphogenesis GO:0048705 skeletal system morphogenesis GO:0048706 embryonic skeletal system development GO:0048736 appendage development GO:0048839 inner ear development GO:0048844 artery morphogenesis GO:0051216 cartilage development GO:0060021 palate development GO:0060173 limb development GO:0060840 artery development GO:0061448 connective tissue development GO:0070570 regulation of neuron projection regeneration GO:0090596 sensory organ morphogenesis GO:0097150 neuronal stem cell population maintenance GO:0098727 maintenance of cell number GO:1904888 cranial skeletal system development |
Molecular Function |
GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001104 RNA polymerase II transcription cofactor activity GO:0001105 RNA polymerase II transcription coactivator activity GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding GO:0003713 transcription coactivator activity GO:0071837 HMG box domain binding GO:0098811 transcriptional repressor activity, RNA polymerase II activating transcription factor binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | PRRX1 |
Name | paired related homeobox 1 |
Aliases | PHOX1; PMX1; paired mesoderm homeo box 1; AGOTC; PRX-1; homeobox protein PHOX1; paired mesoderm homeobox 1 i ...... |
Chromosomal Location | 1q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PRRX1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PRRX1 |
Name | paired related homeobox 1 |
Aliases | PHOX1; PMX1; paired mesoderm homeo box 1; AGOTC; PRX-1; homeobox protein PHOX1; paired mesoderm homeobox 1 i ...... |
Chromosomal Location | 1q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PRRX1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | PRRX1 |
Name | paired related homeobox 1 |
Aliases | PHOX1; PMX1; paired mesoderm homeo box 1; AGOTC; PRX-1; homeobox protein PHOX1; paired mesoderm homeobox 1 i ...... |
Chromosomal Location | 1q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PRRX1 in various data sets.
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Points in the above scatter plot represent the mutation difference of PRRX1 in various data sets.
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Summary | |
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Symbol | PRRX1 |
Name | paired related homeobox 1 |
Aliases | PHOX1; PMX1; paired mesoderm homeo box 1; AGOTC; PRX-1; homeobox protein PHOX1; paired mesoderm homeobox 1 i ...... |
Chromosomal Location | 1q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PRRX1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | PRRX1 |
Name | paired related homeobox 1 |
Aliases | PHOX1; PMX1; paired mesoderm homeo box 1; AGOTC; PRX-1; homeobox protein PHOX1; paired mesoderm homeobox 1 i ...... |
Chromosomal Location | 1q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PRRX1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PRRX1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | PRRX1 |
Name | paired related homeobox 1 |
Aliases | PHOX1; PMX1; paired mesoderm homeo box 1; AGOTC; PRX-1; homeobox protein PHOX1; paired mesoderm homeobox 1 i ...... |
Chromosomal Location | 1q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PRRX1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PRRX1 |
Name | paired related homeobox 1 |
Aliases | PHOX1; PMX1; paired mesoderm homeo box 1; AGOTC; PRX-1; homeobox protein PHOX1; paired mesoderm homeobox 1 i ...... |
Chromosomal Location | 1q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PRRX1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PRRX1 |
Name | paired related homeobox 1 |
Aliases | PHOX1; PMX1; paired mesoderm homeo box 1; AGOTC; PRX-1; homeobox protein PHOX1; paired mesoderm homeobox 1 i ...... |
Chromosomal Location | 1q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PRRX1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PRRX1 |
Name | paired related homeobox 1 |
Aliases | PHOX1; PMX1; paired mesoderm homeo box 1; AGOTC; PRX-1; homeobox protein PHOX1; paired mesoderm homeobox 1 i ...... |
Chromosomal Location | 1q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PRRX1 collected from DrugBank database. |
There is no record. |