Browse PRSS1

Summary
SymbolPRSS1
Nameprotease, serine, 1 (trypsin 1)
Aliases TRYP1; TCR V beta 4.1; beta-trypsin; cationic trypsinogen; digestive zymogen; nonfunctional trypsin 1; tryps ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted, extracellular space.
Domain PF00089 Trypsin
Function

Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.

> Gene Ontology
 
Biological Process GO:0006766 vitamin metabolic process
GO:0006767 water-soluble vitamin metabolic process
GO:0007586 digestion
GO:0009235 cobalamin metabolic process
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0033013 tetrapyrrole metabolic process
GO:0043062 extracellular structure organization
Molecular Function GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0017171 serine hydrolase activity
Cellular Component GO:0072562 blood microparticle
> KEGG and Reactome Pathway
 
KEGG hsa04080 Neuroactive ligand-receptor interaction
hsa04972 Pancreatic secretion
hsa04974 Protein digestion and absorption
Reactome R-HSA-1592389: Activation of Matrix Metalloproteinases
R-HSA-196741: Cobalamin (Cbl, vitamin B12) transport and metabolism
R-HSA-1474228: Degradation of the extracellular matrix
R-HSA-1474244: Extracellular matrix organization
R-HSA-1430728: Metabolism
R-HSA-196854: Metabolism of vitamins and cofactors
R-HSA-196849: Metabolism of water-soluble vitamins and cofactors
Summary
SymbolPRSS1
Nameprotease, serine, 1 (trypsin 1)
Aliases TRYP1; TCR V beta 4.1; beta-trypsin; cationic trypsinogen; digestive zymogen; nonfunctional trypsin 1; tryps ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PRSS1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolPRSS1
Nameprotease, serine, 1 (trypsin 1)
Aliases TRYP1; TCR V beta 4.1; beta-trypsin; cationic trypsinogen; digestive zymogen; nonfunctional trypsin 1; tryps ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PRSS1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPRSS1
Nameprotease, serine, 1 (trypsin 1)
Aliases TRYP1; TCR V beta 4.1; beta-trypsin; cationic trypsinogen; digestive zymogen; nonfunctional trypsin 1; tryps ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PRSS1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1730.733
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.4480.615
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.9670.393
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 4801
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 2801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-1.090.0439
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PRSS1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.88.26.60.452
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.88.56.30.453
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)2117011.8-11.80.193
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)1311018.2-18.20.199
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPRSS1
Nameprotease, serine, 1 (trypsin 1)
Aliases TRYP1; TCR V beta 4.1; beta-trypsin; cationic trypsinogen; digestive zymogen; nonfunctional trypsin 1; tryps ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PRSS1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPRSS1
Nameprotease, serine, 1 (trypsin 1)
Aliases TRYP1; TCR V beta 4.1; beta-trypsin; cationic trypsinogen; digestive zymogen; nonfunctional trypsin 1; tryps ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PRSS1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PRSS1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPRSS1
Nameprotease, serine, 1 (trypsin 1)
Aliases TRYP1; TCR V beta 4.1; beta-trypsin; cationic trypsinogen; digestive zymogen; nonfunctional trypsin 1; tryps ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PRSS1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPRSS1
Nameprotease, serine, 1 (trypsin 1)
Aliases TRYP1; TCR V beta 4.1; beta-trypsin; cationic trypsinogen; digestive zymogen; nonfunctional trypsin 1; tryps ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PRSS1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPRSS1
Nameprotease, serine, 1 (trypsin 1)
Aliases TRYP1; TCR V beta 4.1; beta-trypsin; cationic trypsinogen; digestive zymogen; nonfunctional trypsin 1; tryps ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PRSS1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPRSS1
Nameprotease, serine, 1 (trypsin 1)
Aliases TRYP1; TCR V beta 4.1; beta-trypsin; cationic trypsinogen; digestive zymogen; nonfunctional trypsin 1; tryps ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PRSS1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting PRSS1.
ID Name Drug Type Targets #Targets
DB01665ZK-800270Small MoleculePRSS11
DB01705Bis(5-Amidino-Benzimidazolyl)MethaneSmall MoleculePRSS11
DB017252-{2-hydroxy-[1,1'-biphenyl]-3-yl}-1H-1,3-benzodiazole-5-carboximidamideSmall MoleculeF2, PLAU, PRSS13
DB01737Nalpha-(2-Naphthylsulfonylglycyl)-3-Amidino-D,L-Phenylalanine-IsopropylesterSmall MoleculePRSS11
DB01741CRA_17693Small MoleculePRSS11
DB01745N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)Isopipecolinic Acid Methyl EsterSmall MoleculePRSS11
DB01767Hemi-BabimSmall MoleculeF2, PRSS12
DB01771CRA_10991Small MoleculePRSS11
DB01805MonoisopropylphosphorylserineSmall MoleculeACHE, PRSS1, PRSS23
DB01836[4-(6-Chloro-Naphthalene-2-Sulfonyl)-Piperazin-1-Yl]-(3,4,5,6-Tetrahydro-2h-[1,4']Bipyridinyl-4-Yl)-MethanoneSmall MoleculePRSS11
DB01876Bis(5-Amidino-2-Benzimidazolyl)MethanoneSmall MoleculePRSS11
DB019052-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-CarboxamidineSmall MoleculePLAU, PRSS12
DB019395-Amidino-BenzimidazoleSmall MoleculePRSS11
DB02045AmylamineSmall MoleculePRSS11
DB02063CRA_16847Small MoleculePRSS11
DB02081Bis-BenzamidineSmall MoleculePRSS11
DB02084CRA_17312Small MoleculePRSS11
DB02112Zk-806450Small MoleculePRSS11
DB02269[4-({[5-Benzyloxy-1-(3-Carbamimidoyl-Benzyl)-1h-Indole-2-Carbonyl]-Amino}-Methyl)-Phenyl]-Trimethyl-AmmoniumSmall MoleculePRSS11
DB022872-(2-Hydroxy-Phenyl)-3h-Benzoimidazole-5-CarboxamidineSmall MoleculeF2, PLAU, PRSS13
DB02288CRA_9334Small MoleculePRSS11
DB023544-{[1-Methyl-5-(2-Methyl-Benzoimidazol-1-Ylmethyl)-1h-Benzoimidazol-2-Ylmethyl]-Amino}-BenzamidineSmall MoleculePRSS11
DB02366CRA_10762Small MoleculePRSS11
DB02435AminomethylcyclohexaneSmall MoleculePRSS11
DB024632-(2-Hydroxy-Phenyl)-1h-Indole-5-CarboxamidineSmall MoleculePRSS11
DB02464BenzylamineSmall MoleculePRSS1, PRSS22
DB02526CRA_10655Small MoleculePLAU, PRSS12
DB02665(1R,2S)-2-PhenylcyclopropanaminiumSmall MoleculePRSS11
DB02744RPR131247Small MoleculePRSS11
DB02812(2s,4r)-1-Acetyl-N-[(1s)-4-[(Aminoiminomethyl)Amino]-1-(2-Benzothiazolylcarbonyl)Butyl]-4-Hydroxy-2-PyrrolidinecarboxamideSmall MoleculePRSS11
DB02875CRA_1802Small MoleculePRSS11
DB02989CRA_10972Small MoleculePRSS11
DB03016CRA_1801Small MoleculePRSS11
DB03081Crc200 (Chiron-Behring)Small MoleculePRSS11
DB03127BenzamidineSmall MoleculeATOX1, CSNK2A1, ECI1, KLK1, KLK6, PLAU, PRSS1, PRSS2, PRSS3, ST1410
DB031364-Iodobenzo[B]Thiophene-2-CarboxamidineSmall MoleculeF2, PLAU, PRSS13
DB03159CRA_8696Small MoleculeF2, PLAU, PRSS13
DB03173CRA_10433Small MoleculePRSS11
DB03213Bis(5-Amidino-2-Benzimidazolyl)Methane KetoneSmall MoleculePRSS11
DB032434-FluorobenzylamineSmall MoleculePRSS11
DB03251RWJ-51084Small MoleculePRSS11
DB033371-(2-Amidinophenyl)-3-(Phenoxyphenyl)UreaSmall MoleculePRSS11
DB03373ZK-806711Small MoleculePRSS11
DB033743,5-DiiodotyrosineSmall MoleculeIYD, PKIA, PRKACA, PRSS14
DB034171-(4-Tert-Butylcarbamoyl-Piperazine-1-Carbonyl)-3-(3-Guanidino-Propyl)-4-Oxo-Azetidine-2-Carboxylic AcidSmall MoleculePRSS11
DB03443Bis(5-Amidino-Benzimidazolyl)Methanone ZincSmall MoleculePRSS11
DB03555CRA_11092Small MoleculePRSS11
DB03595CRA_9785Small MoleculePRSS11
DB03608DiminazeneSmall MoleculeAOC1, PRDX5, PRSS13
DB03643CRA_1144Small MoleculeHPN, PRSS12
DB038656-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-CarboxamidineSmall MoleculeF2, HPN, PLAU, PRSS14
DB03876Thieno[2,3-B]Pyridine-2-CarboxamidineSmall MoleculePLAU, PRSS12
DB03976PhosphorylisopropaneSmall MoleculeCTRB1, PRSS1, PRSS23
DB04008Bis(5-Amidino-Benzimidazolyl)Methane ZincSmall MoleculePRSS11
DB04107[(1-{2[(4-Carbamimidoyl-Phenylamino)-Methyl]-1-Methyl-1h-Benzoimidazol-5-Yl}-Cyclopropyl)-Pyridin-2-Yl-Methyleneaminooxy]-Acetic Acid Ethyl EsterSmall MoleculePRSS11
DB04125N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)-4-Acetyl-PiperazineSmall MoleculePRSS11
DB04215CRA_9076Small MoleculePRSS11
DB04238N-Alpha-(2-Naphthylsulfonyl)-N-(3-Amidino-L-Phenylalaninyl)-D-Pipecolinic AcidSmall MoleculePRSS11
DB04246CRA_23653Small MoleculePRSS11
DB04269Cyclotheonamide ASmall MoleculePRSS11
DB04301Bis(5-Amidino-2-Benzimidazolyl)Methane Ketone HydrateSmall MoleculePRSS11
DB043114-PhenylbutylamineSmall MoleculePRSS11
DB04325PhenethylamineSmall MoleculePRSS1, PRSS22
DB043361-(4-Amidinophenyl)-3-(4-Chlorophenyl)UreaSmall MoleculePRSS11
DB04391Aeruginosin 98-BSmall MoleculePRSS11
DB044103-PhenylpropylamineSmall MoleculePRSS1, PRSS22
DB04424RPR128515Small MoleculePRSS11
DB04432ZK-805623Small MoleculePRSS11
DB044422-(2-Oxo-1,2-Dihydro-Pyridin-3-Yl)-1h-Benzoimidazole-5-CarboxamidineSmall MoleculePRSS11
DB04446Benzo[B]Thiophene-2-CarboxamidineSmall MoleculePRSS11
DB04470CRA_10656Small MoleculePRSS11
DB04563CRA_9678Small MoleculePRSS11
DB046544-PIPERIDIN-4-YLBUTANALSmall MoleculePRSS1, TPSB22
DB047902,5-bis-o-{3-[amino(imino)methyl]phenyl}-1,4:3,6-dianhydro-d-glucitolSmall MoleculePRSS11
DB047912-O-(4'-AMIDINOPHENYL)-5-O-(3''-AMIDINOPHENYL)-1,4:3,6-DIANHYDRO-D-SORBITOLSmall MoleculePRSS11
DB047922,5-O,O-BIS-{4',4''-AMIDINOPHENYL}-1,4:3,6-DIANHYDRO-D-SORBITOLSmall MoleculePRSS11
DB047931,4:3,6-Dianhydro-2-O-(3-carbamimidoylphenyl)-5-O-(4-carbamimidoylphenyl)-D-glucitolSmall MoleculePRSS11
DB06692AprotininBiotechCTRB1, KLK1, PLG, PRSS14
DB06840diethyl [(1R)-1,5-diaminopentyl]boronateSmall MoleculePRSS11
DB06845(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentylamino)ethanoyl)pyrrolidine-2-carboxamideSmall MoleculeF2, PRSS12
DB06850(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexylamino)ethanoyl)pyrrolidine-2-carboxamideSmall MoleculeF2, PRSS12
DB06853N-cycloheptylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamideSmall MoleculeF2, PRSS12
DB068556-fluoro-2-(2-hydroxy-3-isobutoxy-phenyl)-1H-benzoimidazole-5-carboxamidineSmall MoleculePLAU, PRSS12
DB06858N-cyclooctylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamideSmall MoleculeF2, PRSS12
DB069182-(2-METHYLPHENYL)-1H-INDOLE-6-CARBOXIMIDAMIDESmall MoleculePRSS11
DB069232-(3-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDESmall MoleculePRSS11
DB07088(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentyloxy)ethanoyl)pyrrolidine-2-carboxamideSmall MoleculeF2, PRSS12
DB07091(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexyloxy)ethanoyl)pyrrolidine-2-carboxamideSmall MoleculeF2, PRSS12
DB07095(S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclopentylpropanoyl)pyrrolidine-2-carboxamideSmall MoleculeF2, PRSS12
DB07131(S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclohexylpropanoyl)pyrrolidine-2-carboxamideSmall MoleculeF2, PRSS12
DB072293-{5-[AMINO(IMINIO)METHYL]-1H-INDOL-2-YL}-5-METHOXY-1,1'-BIPHENYL-2-OLATESmall MoleculePRSS11
DB073684-(METHYLSULFONYL)BENZENECARBOXIMIDAMIDESmall MoleculePRSS11
DB074915-amino-2,4,6-tribromobenzene-1,3-dicarboxylic acidSmall MoleculePRSS11
DB07985+/-METHYL 4-(AMINOIMINOMETHYL)-BETA-[3- INH (AMINOIMINO)PHENYL]BENZENE PENTANOATESmall MoleculePRSS11
DB081842-(2-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDESmall MoleculePRSS11
DB082542-NAPHTHALENESULFONIC ACIDSmall MoleculeF2, PRSS12
DB084201-{[1-(2-AMINO-3-PHENYL-PROPIONYL)-PYRROLIDINE-2-CARBONYL]-AMINO}-2-(3-CYANO-PHENYL)-ETHANEBORONIC ACIDSmall MoleculePRSS11
DB08763[N-(BENZYLOXYCARBONYL)AMINO](4-AMIDINOPHENYL)METHANE-PHOSPHONATESmall MoleculePRSS11
DB12598NafamostatSmall MoleculeF10, F12, F2, ICAM1, KLK1, PRSS16