Summary | |
---|---|
Symbol | PSD2 |
Name | pleckstrin and Sec7 domain containing 2 |
Aliases | DKFZp761B0514; EFA6C; 6330404E20Rik; pleckstrin homology and SEC7 domain-containing protein 2; PH and SEC7 d ...... |
Chromosomal Location | 5q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass membrane protein Cell projection, ruffle membrane Cleavage furrow Note=In interphase associated with the plasma membrane, in particular with membrane ruffling regions. In cells undergoing cytokinesis, transiently found around the ingressing cleavage furrow. Not detected at the midbody ring/Flemming body. |
Domain |
PF01369 Sec7 domain |
Function |
- |
Biological Process |
GO:0007265 Ras protein signal transduction GO:0032011 ARF protein signal transduction GO:0032012 regulation of ARF protein signal transduction GO:0046578 regulation of Ras protein signal transduction GO:0051056 regulation of small GTPase mediated signal transduction |
Molecular Function |
GO:0005085 guanyl-nucleotide exchange factor activity GO:0005086 ARF guanyl-nucleotide exchange factor activity GO:0005543 phospholipid binding |
Cellular Component |
GO:0030425 dendrite GO:0043025 neuronal cell body GO:0044297 cell body |
KEGG |
hsa04144 Endocytosis |
Reactome | - |
Summary | |
---|---|
Symbol | PSD2 |
Name | pleckstrin and Sec7 domain containing 2 |
Aliases | DKFZp761B0514; EFA6C; 6330404E20Rik; pleckstrin homology and SEC7 domain-containing protein 2; PH and SEC7 d ...... |
Chromosomal Location | 5q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PSD2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PSD2 |
Name | pleckstrin and Sec7 domain containing 2 |
Aliases | DKFZp761B0514; EFA6C; 6330404E20Rik; pleckstrin homology and SEC7 domain-containing protein 2; PH and SEC7 d ...... |
Chromosomal Location | 5q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of PSD2 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | PSD2 |
Name | pleckstrin and Sec7 domain containing 2 |
Aliases | DKFZp761B0514; EFA6C; 6330404E20Rik; pleckstrin homology and SEC7 domain-containing protein 2; PH and SEC7 d ...... |
Chromosomal Location | 5q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PSD2 in various data sets.
|
Points in the above scatter plot represent the mutation difference of PSD2 in various data sets.
|
Summary | |
---|---|
Symbol | PSD2 |
Name | pleckstrin and Sec7 domain containing 2 |
Aliases | DKFZp761B0514; EFA6C; 6330404E20Rik; pleckstrin homology and SEC7 domain-containing protein 2; PH and SEC7 d ...... |
Chromosomal Location | 5q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PSD2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | PSD2 |
Name | pleckstrin and Sec7 domain containing 2 |
Aliases | DKFZp761B0514; EFA6C; 6330404E20Rik; pleckstrin homology and SEC7 domain-containing protein 2; PH and SEC7 d ...... |
Chromosomal Location | 5q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PSD2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PSD2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | PSD2 |
Name | pleckstrin and Sec7 domain containing 2 |
Aliases | DKFZp761B0514; EFA6C; 6330404E20Rik; pleckstrin homology and SEC7 domain-containing protein 2; PH and SEC7 d ...... |
Chromosomal Location | 5q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PSD2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | PSD2 |
Name | pleckstrin and Sec7 domain containing 2 |
Aliases | DKFZp761B0514; EFA6C; 6330404E20Rik; pleckstrin homology and SEC7 domain-containing protein 2; PH and SEC7 d ...... |
Chromosomal Location | 5q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PSD2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PSD2 |
Name | pleckstrin and Sec7 domain containing 2 |
Aliases | DKFZp761B0514; EFA6C; 6330404E20Rik; pleckstrin homology and SEC7 domain-containing protein 2; PH and SEC7 d ...... |
Chromosomal Location | 5q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PSD2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PSD2 |
Name | pleckstrin and Sec7 domain containing 2 |
Aliases | DKFZp761B0514; EFA6C; 6330404E20Rik; pleckstrin homology and SEC7 domain-containing protein 2; PH and SEC7 d ...... |
Chromosomal Location | 5q31.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PSD2 collected from DrugBank database. |
There is no record. |