Browse PSD2

Summary
SymbolPSD2
Namepleckstrin and Sec7 domain containing 2
Aliases DKFZp761B0514; EFA6C; 6330404E20Rik; pleckstrin homology and SEC7 domain-containing protein 2; PH and SEC7 d ......
Chromosomal Location5q31.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Single-pass membrane protein Cell projection, ruffle membrane Cleavage furrow Note=In interphase associated with the plasma membrane, in particular with membrane ruffling regions. In cells undergoing cytokinesis, transiently found around the ingressing cleavage furrow. Not detected at the midbody ring/Flemming body.
Domain PF01369 Sec7 domain
Function

-

> Gene Ontology
 
Biological Process GO:0007265 Ras protein signal transduction
GO:0032011 ARF protein signal transduction
GO:0032012 regulation of ARF protein signal transduction
GO:0046578 regulation of Ras protein signal transduction
GO:0051056 regulation of small GTPase mediated signal transduction
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0005543 phospholipid binding
Cellular Component GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0044297 cell body
> KEGG and Reactome Pathway
 
KEGG hsa04144 Endocytosis
Reactome -
Summary
SymbolPSD2
Namepleckstrin and Sec7 domain containing 2
Aliases DKFZp761B0514; EFA6C; 6330404E20Rik; pleckstrin homology and SEC7 domain-containing protein 2; PH and SEC7 d ......
Chromosomal Location5q31.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PSD2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolPSD2
Namepleckstrin and Sec7 domain containing 2
Aliases DKFZp761B0514; EFA6C; 6330404E20Rik; pleckstrin homology and SEC7 domain-containing protein 2; PH and SEC7 d ......
Chromosomal Location5q31.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PSD2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPSD2
Namepleckstrin and Sec7 domain containing 2
Aliases DKFZp761B0514; EFA6C; 6330404E20Rik; pleckstrin homology and SEC7 domain-containing protein 2; PH and SEC7 d ......
Chromosomal Location5q31.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PSD2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-1.7920.0226
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.2530.315
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-2.470.0844
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0150.978
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.150.861
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2980.757
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.3520.368
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.430.435
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.5720.0333
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PSD2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11139.109.10.458
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 512200200.294
Summary
SymbolPSD2
Namepleckstrin and Sec7 domain containing 2
Aliases DKFZp761B0514; EFA6C; 6330404E20Rik; pleckstrin homology and SEC7 domain-containing protein 2; PH and SEC7 d ......
Chromosomal Location5q31.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PSD2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPSD2
Namepleckstrin and Sec7 domain containing 2
Aliases DKFZp761B0514; EFA6C; 6330404E20Rik; pleckstrin homology and SEC7 domain-containing protein 2; PH and SEC7 d ......
Chromosomal Location5q31.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PSD2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PSD2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPSD2
Namepleckstrin and Sec7 domain containing 2
Aliases DKFZp761B0514; EFA6C; 6330404E20Rik; pleckstrin homology and SEC7 domain-containing protein 2; PH and SEC7 d ......
Chromosomal Location5q31.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PSD2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPSD2
Namepleckstrin and Sec7 domain containing 2
Aliases DKFZp761B0514; EFA6C; 6330404E20Rik; pleckstrin homology and SEC7 domain-containing protein 2; PH and SEC7 d ......
Chromosomal Location5q31.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PSD2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPSD2
Namepleckstrin and Sec7 domain containing 2
Aliases DKFZp761B0514; EFA6C; 6330404E20Rik; pleckstrin homology and SEC7 domain-containing protein 2; PH and SEC7 d ......
Chromosomal Location5q31.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PSD2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPSD2
Namepleckstrin and Sec7 domain containing 2
Aliases DKFZp761B0514; EFA6C; 6330404E20Rik; pleckstrin homology and SEC7 domain-containing protein 2; PH and SEC7 d ......
Chromosomal Location5q31.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PSD2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.