Summary | |
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Symbol | PSTPIP2 |
Name | proline-serine-threonine phosphatase interacting protein 2 |
Aliases | MAYP; PEST phosphatase-interacting protein 2; Proline-serine-threonine phosphatase-interacting protein 2 |
Chromosomal Location | 18q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Membrane Peripheral membrane protein |
Domain |
PF00611 Fes/CIP4 |
Function |
Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity). |
Biological Process | - |
Molecular Function |
GO:0003779 actin binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | PSTPIP2 |
Name | proline-serine-threonine phosphatase interacting protein 2 |
Aliases | MAYP; PEST phosphatase-interacting protein 2; Proline-serine-threonine phosphatase-interacting protein 2 |
Chromosomal Location | 18q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PSTPIP2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | PSTPIP2 |
Name | proline-serine-threonine phosphatase interacting protein 2 |
Aliases | MAYP; PEST phosphatase-interacting protein 2; Proline-serine-threonine phosphatase-interacting protein 2 |
Chromosomal Location | 18q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PSTPIP2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PSTPIP2 |
Name | proline-serine-threonine phosphatase interacting protein 2 |
Aliases | MAYP; PEST phosphatase-interacting protein 2; Proline-serine-threonine phosphatase-interacting protein 2 |
Chromosomal Location | 18q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PSTPIP2 in various data sets.
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Points in the above scatter plot represent the mutation difference of PSTPIP2 in various data sets.
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Summary | |
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Symbol | PSTPIP2 |
Name | proline-serine-threonine phosphatase interacting protein 2 |
Aliases | MAYP; PEST phosphatase-interacting protein 2; Proline-serine-threonine phosphatase-interacting protein 2 |
Chromosomal Location | 18q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PSTPIP2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PSTPIP2 |
Name | proline-serine-threonine phosphatase interacting protein 2 |
Aliases | MAYP; PEST phosphatase-interacting protein 2; Proline-serine-threonine phosphatase-interacting protein 2 |
Chromosomal Location | 18q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PSTPIP2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PSTPIP2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PSTPIP2 |
Name | proline-serine-threonine phosphatase interacting protein 2 |
Aliases | MAYP; PEST phosphatase-interacting protein 2; Proline-serine-threonine phosphatase-interacting protein 2 |
Chromosomal Location | 18q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PSTPIP2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PSTPIP2 |
Name | proline-serine-threonine phosphatase interacting protein 2 |
Aliases | MAYP; PEST phosphatase-interacting protein 2; Proline-serine-threonine phosphatase-interacting protein 2 |
Chromosomal Location | 18q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PSTPIP2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PSTPIP2 |
Name | proline-serine-threonine phosphatase interacting protein 2 |
Aliases | MAYP; PEST phosphatase-interacting protein 2; Proline-serine-threonine phosphatase-interacting protein 2 |
Chromosomal Location | 18q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PSTPIP2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PSTPIP2 |
Name | proline-serine-threonine phosphatase interacting protein 2 |
Aliases | MAYP; PEST phosphatase-interacting protein 2; Proline-serine-threonine phosphatase-interacting protein 2 |
Chromosomal Location | 18q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PSTPIP2 collected from DrugBank database. |
There is no record. |