Browse PTF1A

Summary
SymbolPTF1A
Namepancreas specific transcription factor, 1a
Aliases PTF1-p48; bHLHa29; PACA; PAGEN2; bHLH transcription factor p48; class A basic helix-loop-helix protein 29; c ......
Chromosomal Location10p12.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Cytoplasm Note=In chronic pancreatitis associated with pancreas cancer preferentially accumulates in the cytoplasm of acinar/ductular complexes. In the cytoplasm loses its ability to form the PTF1 complex (By similarity).
Domain PF00010 Helix-loop-helix DNA-binding domain
Function

Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.

> Gene Ontology
 
Biological Process GO:0001654 eye development
GO:0003407 neural retina development
GO:0007423 sensory organ development
GO:0010842 retina layer formation
GO:0021549 cerebellum development
GO:0022037 metencephalon development
GO:0030522 intracellular receptor signaling pathway
GO:0030902 hindbrain development
GO:0031016 pancreas development
GO:0031017 exocrine pancreas development
GO:0035272 exocrine system development
GO:0035881 amacrine cell differentiation
GO:0043010 camera-type eye development
GO:0045165 cell fate commitment
GO:0048384 retinoic acid receptor signaling pathway
GO:0048592 eye morphogenesis
GO:0048593 camera-type eye morphogenesis
GO:0048663 neuron fate commitment
GO:0048732 gland development
GO:0055123 digestive system development
GO:0060041 retina development in camera-type eye
GO:0060042 retina morphogenesis in camera-type eye
GO:0061074 regulation of neural retina development
GO:0090596 sensory organ morphogenesis
GO:1902866 regulation of retina development in camera-type eye
Molecular Function GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001158 enhancer sequence-specific DNA binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003682 chromatin binding
GO:0035326 enhancer binding
GO:0070888 E-box binding
Cellular Component GO:0005667 transcription factor complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1266738: Developmental Biology
R-HSA-186712: Regulation of beta-cell development
R-HSA-210747: Regulation of gene expression in early pancreatic precursor cells
Summary
SymbolPTF1A
Namepancreas specific transcription factor, 1a
Aliases PTF1-p48; bHLHa29; PACA; PAGEN2; bHLH transcription factor p48; class A basic helix-loop-helix protein 29; c ......
Chromosomal Location10p12.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PTF1A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolPTF1A
Namepancreas specific transcription factor, 1a
Aliases PTF1-p48; bHLHa29; PACA; PAGEN2; bHLH transcription factor p48; class A basic helix-loop-helix protein 29; c ......
Chromosomal Location10p12.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PTF1A in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.56 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolPTF1A
Namepancreas specific transcription factor, 1a
Aliases PTF1-p48; bHLHa29; PACA; PAGEN2; bHLH transcription factor p48; class A basic helix-loop-helix protein 29; c ......
Chromosomal Location10p12.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PTF1A in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.4270.598
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.6270.168
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.0780.454
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 4801
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 2801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0780.548
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PTF1A in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPTF1A
Namepancreas specific transcription factor, 1a
Aliases PTF1-p48; bHLHa29; PACA; PAGEN2; bHLH transcription factor p48; class A basic helix-loop-helix protein 29; c ......
Chromosomal Location10p12.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PTF1A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPTF1A
Namepancreas specific transcription factor, 1a
Aliases PTF1-p48; bHLHa29; PACA; PAGEN2; bHLH transcription factor p48; class A basic helix-loop-helix protein 29; c ......
Chromosomal Location10p12.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PTF1A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PTF1A.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPTF1A
Namepancreas specific transcription factor, 1a
Aliases PTF1-p48; bHLHa29; PACA; PAGEN2; bHLH transcription factor p48; class A basic helix-loop-helix protein 29; c ......
Chromosomal Location10p12.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PTF1A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPTF1A
Namepancreas specific transcription factor, 1a
Aliases PTF1-p48; bHLHa29; PACA; PAGEN2; bHLH transcription factor p48; class A basic helix-loop-helix protein 29; c ......
Chromosomal Location10p12.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PTF1A expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPTF1A
Namepancreas specific transcription factor, 1a
Aliases PTF1-p48; bHLHa29; PACA; PAGEN2; bHLH transcription factor p48; class A basic helix-loop-helix protein 29; c ......
Chromosomal Location10p12.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PTF1A and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPTF1A
Namepancreas specific transcription factor, 1a
Aliases PTF1-p48; bHLHa29; PACA; PAGEN2; bHLH transcription factor p48; class A basic helix-loop-helix protein 29; c ......
Chromosomal Location10p12.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PTF1A collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.