Summary | |
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Symbol | PTGER1 |
Name | prostaglandin E receptor 1 (subtype EP1), 42kDa |
Aliases | EP1; prostaglandin E receptor 1 (subtype EP1), 42kD; PGE receptor EP1 subtype; PGE receptor, EP1 subtype; PG ...... |
Chromosomal Location | 19p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Domain |
PF00001 7 transmembrane receptor (rhodopsin family) |
Function |
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues. |
Biological Process |
GO:0002237 response to molecule of bacterial origin GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0032496 response to lipopolysaccharide GO:0051480 regulation of cytosolic calcium ion concentration GO:0055074 calcium ion homeostasis GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis |
Molecular Function |
GO:0004953 icosanoid receptor activity GO:0004954 prostanoid receptor activity GO:0004955 prostaglandin receptor activity GO:0004957 prostaglandin E receptor activity |
Cellular Component | - |
KEGG |
hsa04020 Calcium signaling pathway hsa04080 Neuroactive ligand-receptor interaction |
Reactome |
R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-391903: Eicosanoid ligand-binding receptors R-HSA-416476: G alpha (q) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-391908: Prostanoid ligand receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
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Symbol | PTGER1 |
Name | prostaglandin E receptor 1 (subtype EP1), 42kDa |
Aliases | EP1; prostaglandin E receptor 1 (subtype EP1), 42kD; PGE receptor EP1 subtype; PGE receptor, EP1 subtype; PG ...... |
Chromosomal Location | 19p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PTGER1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between PTGER1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | PTGER1 |
Name | prostaglandin E receptor 1 (subtype EP1), 42kDa |
Aliases | EP1; prostaglandin E receptor 1 (subtype EP1), 42kD; PGE receptor EP1 subtype; PGE receptor, EP1 subtype; PG ...... |
Chromosomal Location | 19p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PTGER1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PTGER1 |
Name | prostaglandin E receptor 1 (subtype EP1), 42kDa |
Aliases | EP1; prostaglandin E receptor 1 (subtype EP1), 42kD; PGE receptor EP1 subtype; PGE receptor, EP1 subtype; PG ...... |
Chromosomal Location | 19p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PTGER1 in various data sets.
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Points in the above scatter plot represent the mutation difference of PTGER1 in various data sets.
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Summary | |
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Symbol | PTGER1 |
Name | prostaglandin E receptor 1 (subtype EP1), 42kDa |
Aliases | EP1; prostaglandin E receptor 1 (subtype EP1), 42kD; PGE receptor EP1 subtype; PGE receptor, EP1 subtype; PG ...... |
Chromosomal Location | 19p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PTGER1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PTGER1 |
Name | prostaglandin E receptor 1 (subtype EP1), 42kDa |
Aliases | EP1; prostaglandin E receptor 1 (subtype EP1), 42kD; PGE receptor EP1 subtype; PGE receptor, EP1 subtype; PG ...... |
Chromosomal Location | 19p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PTGER1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PTGER1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PTGER1 |
Name | prostaglandin E receptor 1 (subtype EP1), 42kDa |
Aliases | EP1; prostaglandin E receptor 1 (subtype EP1), 42kD; PGE receptor EP1 subtype; PGE receptor, EP1 subtype; PG ...... |
Chromosomal Location | 19p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PTGER1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PTGER1 |
Name | prostaglandin E receptor 1 (subtype EP1), 42kDa |
Aliases | EP1; prostaglandin E receptor 1 (subtype EP1), 42kD; PGE receptor EP1 subtype; PGE receptor, EP1 subtype; PG ...... |
Chromosomal Location | 19p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PTGER1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PTGER1 |
Name | prostaglandin E receptor 1 (subtype EP1), 42kDa |
Aliases | EP1; prostaglandin E receptor 1 (subtype EP1), 42kD; PGE receptor EP1 subtype; PGE receptor, EP1 subtype; PG ...... |
Chromosomal Location | 19p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PTGER1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PTGER1 |
Name | prostaglandin E receptor 1 (subtype EP1), 42kDa |
Aliases | EP1; prostaglandin E receptor 1 (subtype EP1), 42kD; PGE receptor EP1 subtype; PGE receptor, EP1 subtype; PG ...... |
Chromosomal Location | 19p13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PTGER1 collected from DrugBank database. |
Details on drugs targeting PTGER1.
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