Summary | |
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Symbol | PTGS1 |
Name | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) |
Aliases | PGHS-1; PTGHS; PCOX1; PES-1; PGHS1; PHS1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1; Pro ...... |
Chromosomal Location | 9q32-q33.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. |
Domain |
PF03098 Animal haem peroxidase PF00008 EGF-like domain |
Function |
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells. |
Biological Process |
GO:0001516 prostaglandin biosynthetic process GO:0001676 long-chain fatty acid metabolic process GO:0003013 circulatory system process GO:0006631 fatty acid metabolic process GO:0006633 fatty acid biosynthetic process GO:0006636 unsaturated fatty acid biosynthetic process GO:0006690 icosanoid metabolic process GO:0006692 prostanoid metabolic process GO:0006693 prostaglandin metabolic process GO:0006805 xenobiotic metabolic process GO:0006979 response to oxidative stress GO:0008015 blood circulation GO:0008217 regulation of blood pressure GO:0009410 response to xenobiotic stimulus GO:0009636 response to toxic substance GO:0016053 organic acid biosynthetic process GO:0019369 arachidonic acid metabolic process GO:0019371 cyclooxygenase pathway GO:0033559 unsaturated fatty acid metabolic process GO:0044283 small molecule biosynthetic process GO:0046394 carboxylic acid biosynthetic process GO:0046456 icosanoid biosynthetic process GO:0046457 prostanoid biosynthetic process GO:0071466 cellular response to xenobiotic stimulus GO:0072330 monocarboxylic acid biosynthetic process GO:0098754 detoxification GO:0098869 cellular oxidant detoxification GO:1990748 cellular detoxification |
Molecular Function |
GO:0004601 peroxidase activity GO:0004666 prostaglandin-endoperoxide synthase activity GO:0016209 antioxidant activity GO:0016684 oxidoreductase activity, acting on peroxide as acceptor GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0020037 heme binding GO:0046906 tetrapyrrole binding GO:0051213 dioxygenase activity |
Cellular Component |
GO:0001750 photoreceptor outer segment GO:0005929 cilium GO:0031513 nonmotile primary cilium GO:0072372 primary cilium |
KEGG |
hsa04611 Platelet activation hsa04726 Serotonergic synapse hsa00590 Arachidonic acid metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-2142753: Arachidonic acid metabolism R-HSA-211859: Biological oxidations R-HSA-140180: COX reactions R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-211945: Phase 1 - Functionalization of compounds R-HSA-2162123: Synthesis of Prostaglandins (PG) and Thromboxanes (TX) |
Summary | |
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Symbol | PTGS1 |
Name | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) |
Aliases | PGHS-1; PTGHS; PCOX1; PES-1; PGHS1; PHS1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1; Pro ...... |
Chromosomal Location | 9q32-q33.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PTGS1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between PTGS1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | PTGS1 |
Name | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) |
Aliases | PGHS-1; PTGHS; PCOX1; PES-1; PGHS1; PHS1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1; Pro ...... |
Chromosomal Location | 9q32-q33.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PTGS1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PTGS1 |
Name | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) |
Aliases | PGHS-1; PTGHS; PCOX1; PES-1; PGHS1; PHS1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1; Pro ...... |
Chromosomal Location | 9q32-q33.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PTGS1 in various data sets.
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Points in the above scatter plot represent the mutation difference of PTGS1 in various data sets.
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Summary | |
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Symbol | PTGS1 |
Name | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) |
Aliases | PGHS-1; PTGHS; PCOX1; PES-1; PGHS1; PHS1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1; Pro ...... |
Chromosomal Location | 9q32-q33.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PTGS1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PTGS1 |
Name | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) |
Aliases | PGHS-1; PTGHS; PCOX1; PES-1; PGHS1; PHS1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1; Pro ...... |
Chromosomal Location | 9q32-q33.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PTGS1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PTGS1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PTGS1 |
Name | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) |
Aliases | PGHS-1; PTGHS; PCOX1; PES-1; PGHS1; PHS1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1; Pro ...... |
Chromosomal Location | 9q32-q33.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PTGS1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PTGS1 |
Name | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) |
Aliases | PGHS-1; PTGHS; PCOX1; PES-1; PGHS1; PHS1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1; Pro ...... |
Chromosomal Location | 9q32-q33.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PTGS1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PTGS1 |
Name | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) |
Aliases | PGHS-1; PTGHS; PCOX1; PES-1; PGHS1; PHS1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1; Pro ...... |
Chromosomal Location | 9q32-q33.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PTGS1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PTGS1 |
Name | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) |
Aliases | PGHS-1; PTGHS; PCOX1; PES-1; PGHS1; PHS1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1; Pro ...... |
Chromosomal Location | 9q32-q33.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PTGS1 collected from DrugBank database. |
Details on drugs targeting PTGS1.
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