Browse PTGS1

Summary
SymbolPTGS1
Nameprostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Aliases PGHS-1; PTGHS; PCOX1; PES-1; PGHS1; PHS1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1; Pro ......
Chromosomal Location9q32-q33.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Domain PF03098 Animal haem peroxidase
PF00008 EGF-like domain
Function

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.

> Gene Ontology
 
Biological Process GO:0001516 prostaglandin biosynthetic process
GO:0001676 long-chain fatty acid metabolic process
GO:0003013 circulatory system process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006636 unsaturated fatty acid biosynthetic process
GO:0006690 icosanoid metabolic process
GO:0006692 prostanoid metabolic process
GO:0006693 prostaglandin metabolic process
GO:0006805 xenobiotic metabolic process
GO:0006979 response to oxidative stress
GO:0008015 blood circulation
GO:0008217 regulation of blood pressure
GO:0009410 response to xenobiotic stimulus
GO:0009636 response to toxic substance
GO:0016053 organic acid biosynthetic process
GO:0019369 arachidonic acid metabolic process
GO:0019371 cyclooxygenase pathway
GO:0033559 unsaturated fatty acid metabolic process
GO:0044283 small molecule biosynthetic process
GO:0046394 carboxylic acid biosynthetic process
GO:0046456 icosanoid biosynthetic process
GO:0046457 prostanoid biosynthetic process
GO:0071466 cellular response to xenobiotic stimulus
GO:0072330 monocarboxylic acid biosynthetic process
GO:0098754 detoxification
GO:0098869 cellular oxidant detoxification
GO:1990748 cellular detoxification
Molecular Function GO:0004601 peroxidase activity
GO:0004666 prostaglandin-endoperoxide synthase activity
GO:0016209 antioxidant activity
GO:0016684 oxidoreductase activity, acting on peroxide as acceptor
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046906 tetrapyrrole binding
GO:0051213 dioxygenase activity
Cellular Component GO:0001750 photoreceptor outer segment
GO:0005929 cilium
GO:0031513 nonmotile primary cilium
GO:0072372 primary cilium
> KEGG and Reactome Pathway
 
KEGG hsa04611 Platelet activation
hsa04726 Serotonergic synapse
hsa00590 Arachidonic acid metabolism
hsa01100 Metabolic pathways
Reactome R-HSA-2142753: Arachidonic acid metabolism
R-HSA-211859: Biological oxidations
R-HSA-140180: COX reactions
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-211945: Phase 1 - Functionalization of compounds
R-HSA-2162123: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Summary
SymbolPTGS1
Nameprostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Aliases PGHS-1; PTGHS; PCOX1; PES-1; PGHS1; PHS1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1; Pro ......
Chromosomal Location9q32-q33.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PTGS1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between PTGS1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
18648368Colon CacinomaInhibit immunityDespite studies strongly implicating tumour-expressed FasL as a major inhibitor of the anti-tumour immune response, little is known about the mechanisms that regulate FasL expression in tumours. In this study, we show that the cyclooxygenase (COX) signalling pathway, and in particular prostaglandin E(2) (PGE(2)), plays a role in the upregulation of FasL expression in colon cancer. Suppression of either COX-2 or COX-1 by RNA interference in HCA-7 and HT29 colon tumour cells reduced FasL expression at both the mRNA and protein level.
Summary
SymbolPTGS1
Nameprostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Aliases PGHS-1; PTGHS; PCOX1; PES-1; PGHS1; PHS1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1; Pro ......
Chromosomal Location9q32-q33.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PTGS1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPTGS1
Nameprostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Aliases PGHS-1; PTGHS; PCOX1; PES-1; PGHS1; PHS1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1; Pro ......
Chromosomal Location9q32-q33.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PTGS1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0320.944
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.6780.552
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.5580.489
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.9230.296
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.480.842
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.4860.61
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.5460.242
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.7070.559
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.3260.815
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.5010.763
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.1560.947
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.4090.0479
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PTGS1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.14.170.339
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.15.160.373
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.85.9-1.11
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.79.1-1.41
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.63.7-1.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.27.1-0.91
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPTGS1
Nameprostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Aliases PGHS-1; PTGHS; PCOX1; PES-1; PGHS1; PHS1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1; Pro ......
Chromosomal Location9q32-q33.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PTGS1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPTGS1
Nameprostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Aliases PGHS-1; PTGHS; PCOX1; PES-1; PGHS1; PHS1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1; Pro ......
Chromosomal Location9q32-q33.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PTGS1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PTGS1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPTGS1
Nameprostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Aliases PGHS-1; PTGHS; PCOX1; PES-1; PGHS1; PHS1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1; Pro ......
Chromosomal Location9q32-q33.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PTGS1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPTGS1
Nameprostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Aliases PGHS-1; PTGHS; PCOX1; PES-1; PGHS1; PHS1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1; Pro ......
Chromosomal Location9q32-q33.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PTGS1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPTGS1
Nameprostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Aliases PGHS-1; PTGHS; PCOX1; PES-1; PGHS1; PHS1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1; Pro ......
Chromosomal Location9q32-q33.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PTGS1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPTGS1
Nameprostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Aliases PGHS-1; PTGHS; PCOX1; PES-1; PGHS1; PHS1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1; Pro ......
Chromosomal Location9q32-q33.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PTGS1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting PTGS1.
ID Name Drug Type Targets #Targets
DB00154Dihomo-gamma-linolenic acidSmall MoleculePTGS1, PTGS22
DB00159IcosapentSmall MoleculeACSL3, ACSL4, FADS1, FFAR1, PPARA, PPARD, PPARG, PTGS1, PTGS2, SLC ......11
DB00244MesalazineSmall MoleculeALOX5, CHUK, IKBKB, MPO, PPARG, PTGS1, PTGS27
DB00316AcetaminophenSmall MoleculeFAAH, GSTP1, PTGS1, PTGS2, TRPV15
DB00328IndomethacinSmall MoleculeAKR1C3, GLO1, PLA2G2A, PPARA, PPARG, PTGDR2, PTGR2, PTGS1, PTGS29
DB00350MinoxidilSmall MoleculeKCNJ1, PTGS1, REN3
DB00461NabumetoneSmall MoleculePTGS1, PTGS22
DB00465KetorolacSmall MoleculePTGS1, PTGS22
DB00469TenoxicamSmall MoleculePTGS1, PTGS22
DB00500TolmetinSmall MoleculePTGS1, PTGS22
DB00554PiroxicamSmall MoleculePTGS1, PTGS22
DB00573FenoprofenSmall MoleculePPARA, PPARG, PTGS1, PTGS24
DB00586DiclofenacSmall MoleculeALOX5, ASIC1, KCNQ2, KCNQ3, PLA2G2A, PTGS1, PTGS2, SCN4A8
DB00605SulindacSmall MoleculeAKR1B1, AKR1B10, MAPK3, PPARD, PTGDR2, PTGS1, PTGS27
DB00711DiethylcarbamazineSmall MoleculeALOX5, PTGS12
DB00712FlurbiprofenSmall MoleculePTGS1, PTGS22
DB00749EtodolacSmall MoleculePTGS1, PTGS2, RXRA3
DB00784Mefenamic acidSmall MoleculePTGS1, PTGS22
DB00788NaproxenSmall MoleculePTGS1, PTGS22
DB00795SulfasalazineSmall MoleculeACAT1, ALOX5, CHUK, IKBKB, PLA2G1B, PPARG, PTGS1, PTGS2, SLC7A11, ......10
DB00812PhenylbutazoneSmall MoleculePTGIS, PTGS1, PTGS23
DB00814MeloxicamSmall MoleculePTGS1, PTGS22
DB00821CarprofenSmall MoleculePTGS1, PTGS22
DB00861DiflunisalSmall MoleculePTGS1, PTGS22
DB00870SuprofenSmall MoleculePTGS1, PTGS22
DB00936Salicylic acidSmall MoleculeAKR1C1, PTGS1, PTGS23
DB00939Meclofenamic acidSmall MoleculeALOX5, KCNQ2, KCNQ3, PTGS1, PTGS25
DB00945Acetylsalicylic acidSmall MoleculeAKR1C1, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, ......18
DB00963BromfenacSmall MoleculePTGS1, PTGS22
DB00991OxaprozinSmall MoleculePTGS1, PTGS22
DB01009KetoprofenSmall MoleculeCXCR1, PTGS1, PTGS23
DB01014BalsalazideSmall MoleculeALOX5, PPARG, PTGS1, PTGS24
DB01050IbuprofenSmall MoleculeBCL2, CFTR, FABP2, PLAT, PPARA, PPARG, PTGS1, PTGS2, SLC15A1, THBD10
DB01283LumiracoxibSmall MoleculePTGS1, PTGS22
DB01397Magnesium salicylateSmall MoleculePTGS1, PTGS22
DB01399SalsalateSmall MoleculePTGS1, PTGS22
DB01401Choline magnesium trisalicylateSmall MoleculePTGS1, PTGS22
DB01419AntrafenineSmall MoleculePTGS1, PTGS22
DB01435AntipyrineSmall MoleculePTGS1, PTGS22
DB01600Tiaprofenic acidSmall MoleculePTGS1, PTGS22
DB01837O-acetyl-L-serineSmall MoleculePTGS11
DB01892HyperforinSmall MoleculeALOX5, NR1I2, PTGS13
DB020472-(1,1'-Biphenyl-4-Yl)Propanoic AcidSmall MoleculePTGS11
DB02110Protoporphyrin Ix Containing CoSmall MoleculeCYCS, PTGS12
DB021982-Bromoacetyl GroupSmall MoleculePTGS11
DB02266Flufenamic AcidSmall MoleculeAKR1C3, AR, PPARA, PPARG, PTGS1, PTGS26
DB02379Beta-D-GlucoseSmall MoleculeAMY1A, AMY2A, AMY2B, GCK, GLT6D1, GNPDA1, HK1, IFNB1, KRTAP5-2, KR ......22
DB02709ResveratrolSmall MoleculeAHR, AKT1, ALOX15, ALOX5, APP, CBR1, CLEC14A, CSNK2A1, ESR1, ITGA5 ......25
DB02773(3-Chloro-4-Propoxy-Phenyl)-Acetic AcidSmall MoleculePTGS11
DB03667Acetic Acid Salicyloyl-Amino-EsterSmall MoleculePTGS11
DB03752P-(2'-Iodo-5'-Thenoyl)Hydrotropic AcidSmall MoleculePTGS11
DB03753Flurbiprofen Methyl EsterSmall MoleculePTGS11
DB03783PhenacetinSmall MoleculePTGS11
DB04552Niflumic AcidSmall MoleculeCLCNKA, PLA2G1B, PLA2G4A, PTGS1, PTGS25
DB04557Arachidonic AcidSmall MoleculeNR1H4, PPARA, PTGS1, RXRA4
DB04817MetamizoleSmall MoleculePTGS11
DB06725LornoxicamSmall MoleculePTGS1, PTGS22
DB06736AceclofenacSmall MoleculePTGS1, PTGS22
DB06802NepafenacSmall MoleculePTGS1, PTGS22
DB079812-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-n-[(1R)-1-(hydroxymethyl)propyl]acetamideSmall MoleculePTGS11
DB079831-(4-IODOBENZOYL)-5-METHOXY-2-METHYL INDOLE-3-ACETIC ACIDSmall MoleculePTGS11
DB079842-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-n-[(1S)-1-(hydroxymethyl)propyl]acetamideSmall MoleculePTGS11
DB08814TriflusalSmall MoleculeNFKB1, NOS2, PDE10A, PTGS14
DB09212LoxoprofenSmall MoleculePTGS1, PTGS22
DB09213DexibuprofenSmall MoleculeBCL2, CFTR, FABP2, PLAT, PPARG, PTGS1, PTGS2, THBD8
DB09214DexketoprofenSmall MoleculePTGS1, PTGS22
DB09215DroxicamSmall MoleculePTGS1, PTGS22
DB09216Tolfenamic AcidSmall MoleculePTGS1, PTGS22
DB09288PropacetamolSmall MoleculeCNR1, PTGS1, PTGS2, TRPV14
DB09295TalniflumateSmall MoleculeCLCNKA, PTGS1, PTGS23
DB11079Trolamine salicylateSmall MoleculePTGS1, PTGS22
DB12445NitroaspirinSmall MoleculePTGS11
DB13783AcemetacinSmall MoleculePTGS1, PTGS22