Summary | |
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Symbol | PTH1R |
Name | parathyroid hormone 1 receptor |
Aliases | PTHR1; parathyroid hormone receptor 1; PFE; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; par ...... |
Chromosomal Location | 3p22-p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Multi-pass membrane protein |
Domain |
PF00002 7 transmembrane receptor (Secretin family) PF02793 Hormone receptor domain |
Function |
Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. |
Biological Process |
GO:0001501 skeletal system development GO:0001503 ossification GO:0001649 osteoblast differentiation GO:0001894 tissue homeostasis GO:0002062 chondrocyte differentiation GO:0002076 osteoblast development GO:0006066 alcohol metabolic process GO:0006109 regulation of carbohydrate metabolic process GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007568 aging GO:0010675 regulation of cellular carbohydrate metabolic process GO:0010676 positive regulation of cellular carbohydrate metabolic process GO:0010919 regulation of inositol phosphate biosynthetic process GO:0016051 carbohydrate biosynthetic process GO:0019751 polyol metabolic process GO:0021700 developmental maturation GO:0030282 bone mineralization GO:0031214 biomineral tissue development GO:0032958 inositol phosphate biosynthetic process GO:0043255 regulation of carbohydrate biosynthetic process GO:0043647 inositol phosphate metabolic process GO:0044262 cellular carbohydrate metabolic process GO:0044283 small molecule biosynthetic process GO:0044723 single-organism carbohydrate metabolic process GO:0045453 bone resorption GO:0045913 positive regulation of carbohydrate metabolic process GO:0046165 alcohol biosynthetic process GO:0046173 polyol biosynthetic process GO:0046849 bone remodeling GO:0048469 cell maturation GO:0048771 tissue remodeling GO:0048871 multicellular organismal homeostasis GO:0051216 cartilage development GO:0051480 regulation of cytosolic calcium ion concentration GO:0055074 calcium ion homeostasis GO:0060249 anatomical structure homeostasis GO:0060732 positive regulation of inositol phosphate biosynthetic process GO:0061448 connective tissue development GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:1901615 organic hydroxy compound metabolic process GO:1901617 organic hydroxy compound biosynthetic process GO:1902930 regulation of alcohol biosynthetic process GO:1902932 positive regulation of alcohol biosynthetic process |
Molecular Function |
GO:0004991 parathyroid hormone receptor activity GO:0017046 peptide hormone binding GO:0033218 amide binding GO:0042277 peptide binding GO:0042562 hormone binding GO:0043621 protein self-association |
Cellular Component |
GO:0005903 brush border GO:0016323 basolateral plasma membrane GO:0016324 apical plasma membrane GO:0031253 cell projection membrane GO:0031526 brush border membrane GO:0043235 receptor complex GO:0045177 apical part of cell GO:0098862 cluster of actin-based cell projections |
KEGG |
hsa04080 Neuroactive ligand-receptor interaction hsa04961 Endocrine and other factor-regulated calcium reabsorption |
Reactome |
R-HSA-373080: Class B/2 (Secretin family receptors) R-HSA-418555: G alpha (s) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
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Symbol | PTH1R |
Name | parathyroid hormone 1 receptor |
Aliases | PTHR1; parathyroid hormone receptor 1; PFE; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; par ...... |
Chromosomal Location | 3p22-p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PTH1R and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | PTH1R |
Name | parathyroid hormone 1 receptor |
Aliases | PTHR1; parathyroid hormone receptor 1; PFE; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; par ...... |
Chromosomal Location | 3p22-p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PTH1R in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PTH1R |
Name | parathyroid hormone 1 receptor |
Aliases | PTHR1; parathyroid hormone receptor 1; PFE; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; par ...... |
Chromosomal Location | 3p22-p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PTH1R in various data sets.
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Points in the above scatter plot represent the mutation difference of PTH1R in various data sets.
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Summary | |
---|---|
Symbol | PTH1R |
Name | parathyroid hormone 1 receptor |
Aliases | PTHR1; parathyroid hormone receptor 1; PFE; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; par ...... |
Chromosomal Location | 3p22-p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PTH1R. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PTH1R |
Name | parathyroid hormone 1 receptor |
Aliases | PTHR1; parathyroid hormone receptor 1; PFE; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; par ...... |
Chromosomal Location | 3p22-p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PTH1R. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PTH1R. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PTH1R |
Name | parathyroid hormone 1 receptor |
Aliases | PTHR1; parathyroid hormone receptor 1; PFE; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; par ...... |
Chromosomal Location | 3p22-p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PTH1R. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PTH1R |
Name | parathyroid hormone 1 receptor |
Aliases | PTHR1; parathyroid hormone receptor 1; PFE; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; par ...... |
Chromosomal Location | 3p22-p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PTH1R expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PTH1R |
Name | parathyroid hormone 1 receptor |
Aliases | PTHR1; parathyroid hormone receptor 1; PFE; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; par ...... |
Chromosomal Location | 3p22-p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PTH1R and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PTH1R |
Name | parathyroid hormone 1 receptor |
Aliases | PTHR1; parathyroid hormone receptor 1; PFE; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; par ...... |
Chromosomal Location | 3p22-p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PTH1R collected from DrugBank database. |
Details on drugs targeting PTH1R.
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