Summary | |
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Symbol | PTK6 |
Name | protein tyrosine kinase 6 |
Aliases | BRK; PTK6 protein tyrosine kinase 6; breast tumor kinase; protein-tyrosine kinase BRK; tyrosine-protein kina ...... |
Chromosomal Location | 20q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Nucleus. Cell projection, ruffle. Membrane Note=Colocalizes with KHDRBS1, KHDRBS2 or KHDRBS3, within the nucleus. Nuclear localization in epithelial cells of normal prostate but cytoplasmic localization in cancer prostate. |
Domain |
PF07714 Protein tyrosine kinase PF00017 SH2 domain PF00018 SH3 domain |
Function |
Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Associates also with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage-independent survival and migration/invasion. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p190RhoGAP, which promotes association with RASA1/p120RasGAP, inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. PTK6 activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in normal epithelia, while cytoplasmic PTK6 might activate oncogenic signaling pathways.; FUNCTION: Isoform 2 inhibits PTK6 phosphorylation and PTK6 association with other tyrosine-phosphorylated proteins. |
Biological Process |
GO:0001101 response to acid chemical GO:0001933 negative regulation of protein phosphorylation GO:0002065 columnar/cuboidal epithelial cell differentiation GO:0006469 negative regulation of protein kinase activity GO:0007173 epidermal growth factor receptor signaling pathway GO:0007259 JAK-STAT cascade GO:0007260 tyrosine phosphorylation of STAT protein GO:0010720 positive regulation of cell development GO:0010975 regulation of neuron projection development GO:0010976 positive regulation of neuron projection development GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0031346 positive regulation of cell projection organization GO:0032526 response to retinoic acid GO:0033673 negative regulation of kinase activity GO:0038083 peptidyl-tyrosine autophosphorylation GO:0038127 ERBB signaling pathway GO:0038128 ERBB2 signaling pathway GO:0042058 regulation of epidermal growth factor receptor signaling pathway GO:0042326 negative regulation of phosphorylation GO:0042503 tyrosine phosphorylation of Stat3 protein GO:0042506 tyrosine phosphorylation of Stat5 protein GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO:0042516 regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0045666 positive regulation of neuron differentiation GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway GO:0045787 positive regulation of cell cycle GO:0045926 negative regulation of growth GO:0046425 regulation of JAK-STAT cascade GO:0046427 positive regulation of JAK-STAT cascade GO:0046777 protein autophosphorylation GO:0048565 digestive tract development GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation GO:0050769 positive regulation of neurogenesis GO:0051348 negative regulation of transferase activity GO:0051962 positive regulation of nervous system development GO:0055123 digestive system development GO:0060575 intestinal epithelial cell differentiation GO:0061097 regulation of protein tyrosine kinase activity GO:0061099 negative regulation of protein tyrosine kinase activity GO:0071229 cellular response to acid chemical GO:0071300 cellular response to retinoic acid GO:0071396 cellular response to lipid GO:0097696 STAT cascade GO:1901184 regulation of ERBB signaling pathway GO:1901186 positive regulation of ERBB signaling pathway GO:1904892 regulation of STAT cascade GO:1904894 positive regulation of STAT cascade |
Molecular Function |
GO:0004713 protein tyrosine kinase activity GO:0004715 non-membrane spanning protein tyrosine kinase activity |
Cellular Component |
GO:0001726 ruffle GO:0009898 cytoplasmic side of plasma membrane GO:0019897 extrinsic component of plasma membrane GO:0019898 extrinsic component of membrane GO:0031234 extrinsic component of cytoplasmic side of plasma membrane GO:0031252 cell leading edge GO:0098552 side of membrane GO:0098562 cytoplasmic side of membrane |
KEGG | - |
Reactome |
R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-69656: Cyclin A R-HSA-69202: Cyclin E associated events during G1/S transition R-HSA-8847993: ERBB2 Activates PTK6 Signaling R-HSA-69206: G1/S Transition R-HSA-453279: Mitotic G1-G1/S phases R-HSA-8849474: PTK6 Activates STAT3 R-HSA-8849472: PTK6 Down-Regulation R-HSA-8849473: PTK6 Expression R-HSA-8849470: PTK6 Regulates Cell Cycle R-HSA-8849468: PTK6 Regulates Proteins Involved in RNA Processing R-HSA-8849471: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-HSA-8849469: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-8857538: PTK6 promotes HIF1A stabilization R-HSA-69242: S Phase R-HSA-187577: SCF(Skp2)-mediated degradation of p27/p21 R-HSA-162582: Signal Transduction R-HSA-1227986: Signaling by ERBB2 R-HSA-8848021: Signaling by PTK6 |
Summary | |
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Symbol | PTK6 |
Name | protein tyrosine kinase 6 |
Aliases | BRK; PTK6 protein tyrosine kinase 6; breast tumor kinase; protein-tyrosine kinase BRK; tyrosine-protein kina ...... |
Chromosomal Location | 20q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PTK6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | PTK6 |
Name | protein tyrosine kinase 6 |
Aliases | BRK; PTK6 protein tyrosine kinase 6; breast tumor kinase; protein-tyrosine kinase BRK; tyrosine-protein kina ...... |
Chromosomal Location | 20q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PTK6 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PTK6 |
Name | protein tyrosine kinase 6 |
Aliases | BRK; PTK6 protein tyrosine kinase 6; breast tumor kinase; protein-tyrosine kinase BRK; tyrosine-protein kina ...... |
Chromosomal Location | 20q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PTK6 in various data sets.
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Points in the above scatter plot represent the mutation difference of PTK6 in various data sets.
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Summary | |
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Symbol | PTK6 |
Name | protein tyrosine kinase 6 |
Aliases | BRK; PTK6 protein tyrosine kinase 6; breast tumor kinase; protein-tyrosine kinase BRK; tyrosine-protein kina ...... |
Chromosomal Location | 20q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PTK6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PTK6 |
Name | protein tyrosine kinase 6 |
Aliases | BRK; PTK6 protein tyrosine kinase 6; breast tumor kinase; protein-tyrosine kinase BRK; tyrosine-protein kina ...... |
Chromosomal Location | 20q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PTK6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PTK6. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PTK6 |
Name | protein tyrosine kinase 6 |
Aliases | BRK; PTK6 protein tyrosine kinase 6; breast tumor kinase; protein-tyrosine kinase BRK; tyrosine-protein kina ...... |
Chromosomal Location | 20q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PTK6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PTK6 |
Name | protein tyrosine kinase 6 |
Aliases | BRK; PTK6 protein tyrosine kinase 6; breast tumor kinase; protein-tyrosine kinase BRK; tyrosine-protein kina ...... |
Chromosomal Location | 20q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PTK6 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PTK6 |
Name | protein tyrosine kinase 6 |
Aliases | BRK; PTK6 protein tyrosine kinase 6; breast tumor kinase; protein-tyrosine kinase BRK; tyrosine-protein kina ...... |
Chromosomal Location | 20q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PTK6 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PTK6 |
Name | protein tyrosine kinase 6 |
Aliases | BRK; PTK6 protein tyrosine kinase 6; breast tumor kinase; protein-tyrosine kinase BRK; tyrosine-protein kina ...... |
Chromosomal Location | 20q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PTK6 collected from DrugBank database. |
Details on drugs targeting PTK6.
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