Summary | |
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Symbol | PTK7 |
Name | protein tyrosine kinase 7 (inactive) |
Aliases | CCK4; colon carcinoma kinase 4; PTK7 protein tyrosine kinase 7; protein tyrosine kinase 7; CCK-4; pseudo tyr ...... |
Chromosomal Location | 6p21.1-p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Single-pass type I membrane protein Cell junction Note=Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells. |
Domain |
PF07679 Immunoglobulin I-set domain PF07714 Protein tyrosine kinase |
Function |
Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. |
Biological Process |
GO:0001101 response to acid chemical GO:0001736 establishment of planar polarity GO:0001738 morphogenesis of a polarized epithelium GO:0001838 embryonic epithelial tube formation GO:0001841 neural tube formation GO:0001843 neural tube closure GO:0003205 cardiac chamber development GO:0003231 cardiac ventricle development GO:0003279 cardiac septum development GO:0003281 ventricular septum development GO:0003401 axis elongation GO:0007163 establishment or maintenance of cell polarity GO:0007164 establishment of tissue polarity GO:0007423 sensory organ development GO:0007507 heart development GO:0010720 positive regulation of cell development GO:0010975 regulation of neuron projection development GO:0010976 positive regulation of neuron projection development GO:0014020 primary neural tube formation GO:0016055 Wnt signaling pathway GO:0016331 morphogenesis of embryonic epithelium GO:0021915 neural tube development GO:0030010 establishment of cell polarity GO:0030323 respiratory tube development GO:0030324 lung development GO:0030859 polarized epithelial cell differentiation GO:0031346 positive regulation of cell projection organization GO:0031532 actin cytoskeleton reorganization GO:0032526 response to retinoic acid GO:0035088 establishment or maintenance of apical/basal cell polarity GO:0035089 establishment of apical/basal cell polarity GO:0035148 tube formation GO:0035239 tube morphogenesis GO:0035567 non-canonical Wnt signaling pathway GO:0042249 establishment of planar polarity of embryonic epithelium GO:0042471 ear morphogenesis GO:0042472 inner ear morphogenesis GO:0043583 ear development GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity GO:0045198 establishment of epithelial cell apical/basal polarity GO:0045666 positive regulation of neuron differentiation GO:0045995 regulation of embryonic development GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048839 inner ear development GO:0050769 positive regulation of neurogenesis GO:0051962 positive regulation of nervous system development GO:0060026 convergent extension GO:0060070 canonical Wnt signaling pathway GO:0060071 Wnt signaling pathway, planar cell polarity pathway GO:0060484 lung-associated mesenchyme development GO:0060485 mesenchyme development GO:0060541 respiratory system development GO:0060560 developmental growth involved in morphogenesis GO:0060562 epithelial tube morphogenesis GO:0060606 tube closure GO:0060976 coronary vasculature development GO:0061162 establishment of monopolar cell polarity GO:0061245 establishment or maintenance of bipolar cell polarity GO:0061339 establishment or maintenance of monopolar cell polarity GO:0071229 cellular response to acid chemical GO:0071300 cellular response to retinoic acid GO:0071396 cellular response to lipid GO:0072175 epithelial tube formation GO:0090102 cochlea development GO:0090103 cochlea morphogenesis GO:0090162 establishment of epithelial cell polarity GO:0090175 regulation of establishment of planar polarity GO:0090177 establishment of planar polarity involved in neural tube closure GO:0090178 regulation of establishment of planar polarity involved in neural tube closure GO:0090179 planar cell polarity pathway involved in neural tube closure GO:0090596 sensory organ morphogenesis GO:0198738 cell-cell signaling by wnt GO:1905276 regulation of epithelial tube formation GO:1905330 regulation of morphogenesis of an epithelium GO:2000027 regulation of organ morphogenesis |
Molecular Function |
GO:0015026 coreceptor activity GO:0071936 coreceptor activity involved in Wnt signaling pathway GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway |
Cellular Component |
GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0030055 cell-substrate junction |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | PTK7 |
Name | protein tyrosine kinase 7 (inactive) |
Aliases | CCK4; colon carcinoma kinase 4; PTK7 protein tyrosine kinase 7; protein tyrosine kinase 7; CCK-4; pseudo tyr ...... |
Chromosomal Location | 6p21.1-p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PTK7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between PTK7 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | PTK7 |
Name | protein tyrosine kinase 7 (inactive) |
Aliases | CCK4; colon carcinoma kinase 4; PTK7 protein tyrosine kinase 7; protein tyrosine kinase 7; CCK-4; pseudo tyr ...... |
Chromosomal Location | 6p21.1-p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PTK7 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PTK7 |
Name | protein tyrosine kinase 7 (inactive) |
Aliases | CCK4; colon carcinoma kinase 4; PTK7 protein tyrosine kinase 7; protein tyrosine kinase 7; CCK-4; pseudo tyr ...... |
Chromosomal Location | 6p21.1-p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PTK7 in various data sets.
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Points in the above scatter plot represent the mutation difference of PTK7 in various data sets.
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Summary | |
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Symbol | PTK7 |
Name | protein tyrosine kinase 7 (inactive) |
Aliases | CCK4; colon carcinoma kinase 4; PTK7 protein tyrosine kinase 7; protein tyrosine kinase 7; CCK-4; pseudo tyr ...... |
Chromosomal Location | 6p21.1-p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PTK7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PTK7 |
Name | protein tyrosine kinase 7 (inactive) |
Aliases | CCK4; colon carcinoma kinase 4; PTK7 protein tyrosine kinase 7; protein tyrosine kinase 7; CCK-4; pseudo tyr ...... |
Chromosomal Location | 6p21.1-p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PTK7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PTK7. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PTK7 |
Name | protein tyrosine kinase 7 (inactive) |
Aliases | CCK4; colon carcinoma kinase 4; PTK7 protein tyrosine kinase 7; protein tyrosine kinase 7; CCK-4; pseudo tyr ...... |
Chromosomal Location | 6p21.1-p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PTK7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PTK7 |
Name | protein tyrosine kinase 7 (inactive) |
Aliases | CCK4; colon carcinoma kinase 4; PTK7 protein tyrosine kinase 7; protein tyrosine kinase 7; CCK-4; pseudo tyr ...... |
Chromosomal Location | 6p21.1-p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PTK7 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PTK7 |
Name | protein tyrosine kinase 7 (inactive) |
Aliases | CCK4; colon carcinoma kinase 4; PTK7 protein tyrosine kinase 7; protein tyrosine kinase 7; CCK-4; pseudo tyr ...... |
Chromosomal Location | 6p21.1-p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PTK7 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PTK7 |
Name | protein tyrosine kinase 7 (inactive) |
Aliases | CCK4; colon carcinoma kinase 4; PTK7 protein tyrosine kinase 7; protein tyrosine kinase 7; CCK-4; pseudo tyr ...... |
Chromosomal Location | 6p21.1-p12.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PTK7 collected from DrugBank database. |
There is no record. |