Summary | |
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Symbol | PTPN11 |
Name | protein tyrosine phosphatase, non-receptor type 11 |
Aliases | BPTP3; SH-PTP2; SHP-2; PTP2C; SHP2; NS1; Noonan syndrome 1; JMML; METCDS; PTP-1D; SH-PTP3; PTP-2C; protein-t ...... |
Chromosomal Location | 12q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus |
Domain |
PF00017 SH2 domain PF00102 Protein-tyrosine phosphatase |
Function |
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426). |
Biological Process |
GO:0000075 cell cycle checkpoint GO:0000077 DNA damage checkpoint GO:0000187 activation of MAPK activity GO:0001501 skeletal system development GO:0001667 ameboidal-type cell migration GO:0001894 tissue homeostasis GO:0001959 regulation of cytokine-mediated signaling pathway GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002790 peptide secretion GO:0002791 regulation of peptide secretion GO:0002792 negative regulation of peptide secretion GO:0006470 protein dephosphorylation GO:0006611 protein export from nucleus GO:0006638 neutral lipid metabolic process GO:0006639 acylglycerol metabolic process GO:0006641 triglyceride metabolic process GO:0006644 phospholipid metabolic process GO:0006650 glycerophospholipid metabolic process GO:0006661 phosphatidylinositol biosynthetic process GO:0006869 lipid transport GO:0006913 nucleocytoplasmic transport GO:0007159 leukocyte cell-cell adhesion GO:0007162 negative regulation of cell adhesion GO:0007173 epidermal growth factor receptor signaling pathway GO:0007229 integrin-mediated signaling pathway GO:0007346 regulation of mitotic cell cycle GO:0007409 axonogenesis GO:0007423 sensory organ development GO:0007507 heart development GO:0007548 sex differentiation GO:0007596 blood coagulation GO:0007599 hemostasis GO:0008543 fibroblast growth factor receptor signaling pathway GO:0008643 carbohydrate transport GO:0008645 hexose transport GO:0008654 phospholipid biosynthetic process GO:0009306 protein secretion GO:0009755 hormone-mediated signaling pathway GO:0009914 hormone transport GO:0010001 glial cell differentiation GO:0010171 body morphogenesis GO:0010631 epithelial cell migration GO:0010817 regulation of hormone levels GO:0010827 regulation of glucose transport GO:0010828 positive regulation of glucose transport GO:0010876 lipid localization GO:0014065 phosphatidylinositol 3-kinase signaling GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO:0015749 monosaccharide transport GO:0015758 glucose transport GO:0015833 peptide transport GO:0015850 organic hydroxy compound transport GO:0016311 dephosphorylation GO:0021549 cerebellum development GO:0021575 hindbrain morphogenesis GO:0021587 cerebellum morphogenesis GO:0021695 cerebellar cortex development GO:0021696 cerebellar cortex morphogenesis GO:0021697 cerebellar cortex formation GO:0022037 metencephalon development GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0023061 signal release GO:0030072 peptide hormone secretion GO:0030073 insulin secretion GO:0030099 myeloid cell differentiation GO:0030168 platelet activation GO:0030219 megakaryocyte differentiation GO:0030220 platelet formation GO:0030252 growth hormone secretion GO:0030258 lipid modification GO:0030902 hindbrain development GO:0031294 lymphocyte costimulation GO:0031295 T cell costimulation GO:0031570 DNA integrity checkpoint GO:0032147 activation of protein kinase activity GO:0032368 regulation of lipid transport GO:0032369 negative regulation of lipid transport GO:0032386 regulation of intracellular transport GO:0032528 microvillus organization GO:0032868 response to insulin GO:0032869 cellular response to insulin stimulus GO:0033157 regulation of intracellular protein transport GO:0033277 abortive mitotic cell cycle GO:0033500 carbohydrate homeostasis GO:0033627 cell adhesion mediated by integrin GO:0033628 regulation of cell adhesion mediated by integrin GO:0033629 negative regulation of cell adhesion mediated by integrin GO:0033674 positive regulation of kinase activity GO:0034340 response to type I interferon GO:0035264 multicellular organism growth GO:0035265 organ growth GO:0035335 peptidyl-tyrosine dephosphorylation GO:0035855 megakaryocyte development GO:0035929 steroid hormone secretion GO:0035930 corticosteroid hormone secretion GO:0035933 glucocorticoid secretion GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process GO:0036302 atrioventricular canal development GO:0036344 platelet morphogenesis GO:0038127 ERBB signaling pathway GO:0038179 neurotrophin signaling pathway GO:0040014 regulation of multicellular organism growth GO:0042063 gliogenesis GO:0042110 T cell activation GO:0042445 hormone metabolic process GO:0042593 glucose homeostasis GO:0042886 amide transport GO:0043254 regulation of protein complex assembly GO:0043400 cortisol secretion GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0043434 response to peptide hormone GO:0043583 ear development GO:0044057 regulation of system process GO:0044060 regulation of endocrine process GO:0044344 cellular response to fibroblast growth factor stimulus GO:0044381 glucose import in response to insulin stimulus GO:0045017 glycerolipid biosynthetic process GO:0045088 regulation of innate immune response GO:0045785 positive regulation of cell adhesion GO:0045787 positive regulation of cell cycle GO:0045860 positive regulation of protein kinase activity GO:0045931 positive regulation of mitotic cell cycle GO:0046323 glucose import GO:0046324 regulation of glucose import GO:0046326 positive regulation of glucose import GO:0046474 glycerophospholipid biosynthetic process GO:0046486 glycerolipid metabolic process GO:0046488 phosphatidylinositol metabolic process GO:0046676 negative regulation of insulin secretion GO:0046822 regulation of nucleocytoplasmic transport GO:0046825 regulation of protein export from nucleus GO:0046834 lipid phosphorylation GO:0046854 phosphatidylinositol phosphorylation GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0046887 positive regulation of hormone secretion GO:0046888 negative regulation of hormone secretion GO:0048008 platelet-derived growth factor receptor signaling pathway GO:0048011 neurotrophin TRK receptor signaling pathway GO:0048013 ephrin receptor signaling pathway GO:0048015 phosphatidylinositol-mediated signaling GO:0048017 inositol lipid-mediated signaling GO:0048608 reproductive structure development GO:0048638 regulation of developmental growth GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048708 astrocyte differentiation GO:0048806 genitalia development GO:0048839 inner ear development GO:0048871 multicellular organismal homeostasis GO:0048872 homeostasis of number of cells GO:0048873 homeostasis of number of cells within a tissue GO:0050708 regulation of protein secretion GO:0050709 negative regulation of protein secretion GO:0050796 regulation of insulin secretion GO:0050817 coagulation GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0050878 regulation of body fluid levels GO:0050886 endocrine process GO:0050900 leukocyte migration GO:0051047 positive regulation of secretion GO:0051048 negative regulation of secretion GO:0051051 negative regulation of transport GO:0051168 nuclear export GO:0051169 nuclear transport GO:0051224 negative regulation of protein transport GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051462 regulation of cortisol secretion GO:0051463 negative regulation of cortisol secretion GO:0060020 Bergmann glial cell differentiation GO:0060123 regulation of growth hormone secretion GO:0060125 negative regulation of growth hormone secretion GO:0060249 anatomical structure homeostasis GO:0060323 head morphogenesis GO:0060324 face development GO:0060325 face morphogenesis GO:0060337 type I interferon signaling pathway GO:0060338 regulation of type I interferon-mediated signaling pathway GO:0060348 bone development GO:0060759 regulation of response to cytokine stimulus GO:0060986 endocrine hormone secretion GO:0061458 reproductive system development GO:0061515 myeloid cell development GO:0061564 axon development GO:0061582 intestinal epithelial cell migration GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0071357 cellular response to type I interferon GO:0071375 cellular response to peptide hormone stimulus GO:0071417 cellular response to organonitrogen compound GO:0071593 lymphocyte aggregation GO:0071774 response to fibroblast growth factor GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0090087 regulation of peptide transport GO:0090130 tissue migration GO:0090132 epithelium migration GO:0090276 regulation of peptide hormone secretion GO:0090278 negative regulation of peptide hormone secretion GO:0098751 bone cell development GO:1900076 regulation of cellular response to insulin stimulus GO:1900078 positive regulation of cellular response to insulin stimulus GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903531 negative regulation of secretion by cell GO:1903532 positive regulation of secretion by cell GO:1904950 negative regulation of establishment of protein localization GO:2000831 regulation of steroid hormone secretion GO:2000832 negative regulation of steroid hormone secretion GO:2000846 regulation of corticosteroid hormone secretion GO:2000847 negative regulation of corticosteroid hormone secretion GO:2000849 regulation of glucocorticoid secretion GO:2000850 negative regulation of glucocorticoid secretion GO:2001273 regulation of glucose import in response to insulin stimulus GO:2001275 positive regulation of glucose import in response to insulin stimulus |
Molecular Function |
GO:0001664 G-protein coupled receptor binding GO:0004721 phosphoprotein phosphatase activity GO:0004725 protein tyrosine phosphatase activity GO:0004726 non-membrane spanning protein tyrosine phosphatase activity GO:0005070 SH3/SH2 adaptor activity GO:0005158 insulin receptor binding GO:0016303 1-phosphatidylinositol-3-kinase activity GO:0016791 phosphatase activity GO:0030674 protein binding, bridging GO:0030971 receptor tyrosine kinase binding GO:0031748 D1 dopamine receptor binding GO:0035004 phosphatidylinositol 3-kinase activity GO:0035591 signaling adaptor activity GO:0042578 phosphoric ester hydrolase activity GO:0043274 phospholipase binding GO:0043560 insulin receptor substrate binding GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0050780 dopamine receptor binding GO:0050839 cell adhesion molecule binding GO:0051427 hormone receptor binding GO:0051428 peptide hormone receptor binding GO:0052742 phosphatidylinositol kinase activity GO:0052813 phosphatidylinositol bisphosphate kinase activity GO:0060090 binding, bridging GO:1990782 protein tyrosine kinase binding |
Cellular Component | - |
KEGG |
hsa04014 Ras signaling pathway hsa04360 Axon guidance hsa04630 Jak-STAT signaling pathway hsa04650 Natural killer cell mediated cytotoxicity hsa04670 Leukocyte transendothelial migration hsa04722 Neurotrophin signaling pathway hsa04920 Adipocytokine signaling pathway |
Reactome |
R-HSA-166054: Activated TLR4 signalling R-HSA-936964: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-1280218: Adaptive Immune System R-HSA-422475: Axon guidance R-HSA-389513: CTLA4 inhibitory signaling R-HSA-202733: Cell surface interactions at the vascular wall R-HSA-1500931: Cell-Cell communication R-HSA-2219530: Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-388841: Costimulation by the CD28 family R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-186763: Downstream signal transduction R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR) R-HSA-5654687: Downstream signaling of activated FGFR1 R-HSA-5654696: Downstream signaling of activated FGFR2 R-HSA-5654708: Downstream signaling of activated FGFR3 R-HSA-5654716: Downstream signaling of activated FGFR4 R-HSA-5654693: FRS-mediated FGFR1 signaling R-HSA-5654700: FRS-mediated FGFR2 signaling R-HSA-5654706: FRS-mediated FGFR3 signaling R-HSA-5654712: FRS-mediated FGFR4 signaling R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-180292: GAB1 signalosome R-HSA-114604: GPVI-mediated activation cascade R-HSA-109582: Hemostasis R-HSA-2428924: IGF1R signaling cascade R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-74751: Insulin receptor signalling cascade R-HSA-913531: Interferon Signaling R-HSA-909733: Interferon alpha/beta signaling R-HSA-877300: Interferon gamma signaling R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling R-HSA-6783589: Interleukin-6 family signaling R-HSA-1059683: Interleukin-6 signaling R-HSA-5683057: MAPK family signaling cascades R-HSA-112411: MAPK1 (ERK2) activation R-HSA-5684996: MAPK1/MAPK3 signaling R-HSA-110056: MAPK3 (ERK1) activation R-HSA-8865999: MET activates PTPN11 R-HSA-166166: MyD88-independent TLR3/TLR4 cascade R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-5654726: Negative regulation of FGFR1 signaling R-HSA-5654727: Negative regulation of FGFR2 signaling R-HSA-5654732: Negative regulation of FGFR3 signaling R-HSA-5654733: Negative regulation of FGFR4 signaling R-HSA-199418: Negative regulation of the PI3K/AKT network R-HSA-418886: Netrin mediated repulsion signals R-HSA-373752: Netrin-1 signaling R-HSA-389948: PD-1 signaling R-HSA-210990: PECAM1 interactions R-HSA-5654689: PI-3K cascade R-HSA-5654695: PI-3K cascade R-HSA-5654710: PI-3K cascade R-HSA-5654720: PI-3K cascade R-HSA-109704: PI3K Cascade R-HSA-2219528: PI3K/AKT Signaling in Cancer R-HSA-198203: PI3K/AKT activation R-HSA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-1257604: PIP3 activates AKT signaling R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-418346: Platelet homeostasis R-HSA-432142: Platelet sensitization by LDL R-HSA-1170546: Prolactin receptor signaling R-HSA-112409: RAF-independent MAPK1/3 activation R-HSA-8853659: RET signaling R-HSA-912694: Regulation of IFNA signaling R-HSA-877312: Regulation of IFNG signaling R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-162582: Signal Transduction R-HSA-391160: Signal regulatory protein (SIRP) family interactions R-HSA-177929: Signaling by EGFR R-HSA-190236: Signaling by FGFR R-HSA-5654736: Signaling by FGFR1 R-HSA-5654738: Signaling by FGFR2 R-HSA-5654741: Signaling by FGFR3 R-HSA-5654743: Signaling by FGFR4 R-HSA-74752: Signaling by Insulin receptor R-HSA-449147: Signaling by Interleukins R-HSA-2586552: Signaling by Leptin R-HSA-6806834: Signaling by MET R-HSA-186797: Signaling by PDGF R-HSA-1433557: Signaling by SCF-KIT R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-983705: Signaling by the B Cell Receptor (BCR) R-HSA-166520: Signalling by NGF R-HSA-1295596: Spry regulation of FGF signaling R-HSA-937061: TRIF-mediated TLR3/TLR4 signaling R-HSA-210993: Tie2 Signaling R-HSA-168164: Toll Like Receptor 3 (TLR3) Cascade R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade R-HSA-168898: Toll-Like Receptors Cascades |
Summary | |
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Symbol | PTPN11 |
Name | protein tyrosine phosphatase, non-receptor type 11 |
Aliases | BPTP3; SH-PTP2; SHP-2; PTP2C; SHP2; NS1; Noonan syndrome 1; JMML; METCDS; PTP-1D; SH-PTP3; PTP-2C; protein-t ...... |
Chromosomal Location | 12q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PTPN11 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between PTPN11 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | PTPN11 |
Name | protein tyrosine phosphatase, non-receptor type 11 |
Aliases | BPTP3; SH-PTP2; SHP-2; PTP2C; SHP2; NS1; Noonan syndrome 1; JMML; METCDS; PTP-1D; SH-PTP3; PTP-2C; protein-t ...... |
Chromosomal Location | 12q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PTPN11 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PTPN11 |
Name | protein tyrosine phosphatase, non-receptor type 11 |
Aliases | BPTP3; SH-PTP2; SHP-2; PTP2C; SHP2; NS1; Noonan syndrome 1; JMML; METCDS; PTP-1D; SH-PTP3; PTP-2C; protein-t ...... |
Chromosomal Location | 12q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PTPN11 in various data sets.
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Points in the above scatter plot represent the mutation difference of PTPN11 in various data sets.
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Summary | |
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Symbol | PTPN11 |
Name | protein tyrosine phosphatase, non-receptor type 11 |
Aliases | BPTP3; SH-PTP2; SHP-2; PTP2C; SHP2; NS1; Noonan syndrome 1; JMML; METCDS; PTP-1D; SH-PTP3; PTP-2C; protein-t ...... |
Chromosomal Location | 12q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PTPN11. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | PTPN11 |
Name | protein tyrosine phosphatase, non-receptor type 11 |
Aliases | BPTP3; SH-PTP2; SHP-2; PTP2C; SHP2; NS1; Noonan syndrome 1; JMML; METCDS; PTP-1D; SH-PTP3; PTP-2C; protein-t ...... |
Chromosomal Location | 12q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PTPN11. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PTPN11. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PTPN11 |
Name | protein tyrosine phosphatase, non-receptor type 11 |
Aliases | BPTP3; SH-PTP2; SHP-2; PTP2C; SHP2; NS1; Noonan syndrome 1; JMML; METCDS; PTP-1D; SH-PTP3; PTP-2C; protein-t ...... |
Chromosomal Location | 12q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PTPN11. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | PTPN11 |
Name | protein tyrosine phosphatase, non-receptor type 11 |
Aliases | BPTP3; SH-PTP2; SHP-2; PTP2C; SHP2; NS1; Noonan syndrome 1; JMML; METCDS; PTP-1D; SH-PTP3; PTP-2C; protein-t ...... |
Chromosomal Location | 12q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PTPN11 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PTPN11 |
Name | protein tyrosine phosphatase, non-receptor type 11 |
Aliases | BPTP3; SH-PTP2; SHP-2; PTP2C; SHP2; NS1; Noonan syndrome 1; JMML; METCDS; PTP-1D; SH-PTP3; PTP-2C; protein-t ...... |
Chromosomal Location | 12q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PTPN11 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PTPN11 |
Name | protein tyrosine phosphatase, non-receptor type 11 |
Aliases | BPTP3; SH-PTP2; SHP-2; PTP2C; SHP2; NS1; Noonan syndrome 1; JMML; METCDS; PTP-1D; SH-PTP3; PTP-2C; protein-t ...... |
Chromosomal Location | 12q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PTPN11 collected from DrugBank database. |
Details on drugs targeting PTPN11.
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