Summary | |
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Symbol | PTX3 |
Name | pentraxin 3, long |
Aliases | TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ...... |
Chromosomal Location | 3q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF00354 Pentaxin family |
Function |
Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. |
Biological Process |
GO:0001878 response to yeast GO:0006809 nitric oxide biosynthetic process GO:0006909 phagocytosis GO:0008228 opsonization GO:0009100 glycoprotein metabolic process GO:0009620 response to fungus GO:0019058 viral life cycle GO:0030100 regulation of endocytosis GO:0030260 entry into host cell GO:0035821 modification of morphology or physiology of other organism GO:0043900 regulation of multi-organism process GO:0043901 negative regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0044003 modification by symbiont of host morphology or physiology GO:0044359 modulation of molecular function in other organism GO:0044362 negative regulation of molecular function in other organism GO:0044409 entry into host GO:0044788 modulation by host of viral process GO:0044793 negative regulation by host of viral process GO:0044866 modulation by host of viral exo-alpha-sialidase activity GO:0044867 modulation by host of viral catalytic activity GO:0044868 modulation by host of viral molecular function GO:0044869 negative regulation by host of viral exo-alpha-sialidase activity GO:0044870 modulation by host of viral glycoprotein metabolic process GO:0044871 negative regulation by host of viral glycoprotein metabolic process GO:0045428 regulation of nitric oxide biosynthetic process GO:0045429 positive regulation of nitric oxide biosynthetic process GO:0045807 positive regulation of endocytosis GO:0046209 nitric oxide metabolic process GO:0046596 regulation of viral entry into host cell GO:0046597 negative regulation of viral entry into host cell GO:0046718 viral entry into host cell GO:0048525 negative regulation of viral process GO:0050764 regulation of phagocytosis GO:0050766 positive regulation of phagocytosis GO:0050792 regulation of viral process GO:0051346 negative regulation of hydrolase activity GO:0051701 interaction with host GO:0051702 interaction with symbiont GO:0051806 entry into cell of other organism involved in symbiotic interaction GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051828 entry into other organism involved in symbiotic interaction GO:0051851 modification by host of symbiont morphology or physiology GO:0052055 modulation by symbiont of host molecular function GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction GO:0052203 modulation of catalytic activity in other organism involved in symbiotic interaction GO:0052204 negative regulation of molecular function in other organism involved in symbiotic interaction GO:0052205 modulation of molecular function in other organism involved in symbiotic interaction GO:0052403 negative regulation by host of symbiont catalytic activity GO:0052405 negative regulation by host of symbiont molecular function GO:0052422 modulation by host of symbiont catalytic activity GO:0052428 modification by host of symbiont molecular function GO:0060627 regulation of vesicle-mediated transport GO:0072593 reactive oxygen species metabolic process GO:1903015 regulation of exo-alpha-sialidase activity GO:1903016 negative regulation of exo-alpha-sialidase activity GO:1903018 regulation of glycoprotein metabolic process GO:1903019 negative regulation of glycoprotein metabolic process GO:1903409 reactive oxygen species biosynthetic process GO:1903426 regulation of reactive oxygen species biosynthetic process GO:1903428 positive regulation of reactive oxygen species biosynthetic process GO:1903900 regulation of viral life cycle GO:1903901 negative regulation of viral life cycle GO:1904407 positive regulation of nitric oxide metabolic process GO:2000377 regulation of reactive oxygen species metabolic process GO:2000379 positive regulation of reactive oxygen species metabolic process GO:2001057 reactive nitrogen species metabolic process |
Molecular Function |
GO:0001846 opsonin binding GO:0001848 complement binding GO:0001849 complement component C1q binding GO:0001871 pattern binding GO:0001872 (1->3)-beta-D-glucan binding GO:0030246 carbohydrate binding GO:0030247 polysaccharide binding GO:0046790 virion binding |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6798695: Neutrophil degranulation |
Summary | |
---|---|
Symbol | PTX3 |
Name | pentraxin 3, long |
Aliases | TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ...... |
Chromosomal Location | 3q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PTX3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between PTX3 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | PTX3 |
Name | pentraxin 3, long |
Aliases | TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ...... |
Chromosomal Location | 3q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PTX3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PTX3 |
Name | pentraxin 3, long |
Aliases | TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ...... |
Chromosomal Location | 3q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PTX3 in various data sets.
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Points in the above scatter plot represent the mutation difference of PTX3 in various data sets.
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Summary | |
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Symbol | PTX3 |
Name | pentraxin 3, long |
Aliases | TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ...... |
Chromosomal Location | 3q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PTX3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PTX3 |
Name | pentraxin 3, long |
Aliases | TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ...... |
Chromosomal Location | 3q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PTX3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PTX3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PTX3 |
Name | pentraxin 3, long |
Aliases | TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ...... |
Chromosomal Location | 3q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PTX3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PTX3 |
Name | pentraxin 3, long |
Aliases | TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ...... |
Chromosomal Location | 3q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PTX3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PTX3 |
Name | pentraxin 3, long |
Aliases | TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ...... |
Chromosomal Location | 3q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PTX3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PTX3 |
Name | pentraxin 3, long |
Aliases | TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ...... |
Chromosomal Location | 3q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PTX3 collected from DrugBank database. |
There is no record. |