Browse PTX3

Summary
SymbolPTX3
Namepentraxin 3, long
Aliases TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ......
Chromosomal Location3q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted.
Domain PF00354 Pentaxin family
Function

Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.

> Gene Ontology
 
Biological Process GO:0001878 response to yeast
GO:0006809 nitric oxide biosynthetic process
GO:0006909 phagocytosis
GO:0008228 opsonization
GO:0009100 glycoprotein metabolic process
GO:0009620 response to fungus
GO:0019058 viral life cycle
GO:0030100 regulation of endocytosis
GO:0030260 entry into host cell
GO:0035821 modification of morphology or physiology of other organism
GO:0043900 regulation of multi-organism process
GO:0043901 negative regulation of multi-organism process
GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism
GO:0044003 modification by symbiont of host morphology or physiology
GO:0044359 modulation of molecular function in other organism
GO:0044362 negative regulation of molecular function in other organism
GO:0044409 entry into host
GO:0044788 modulation by host of viral process
GO:0044793 negative regulation by host of viral process
GO:0044866 modulation by host of viral exo-alpha-sialidase activity
GO:0044867 modulation by host of viral catalytic activity
GO:0044868 modulation by host of viral molecular function
GO:0044869 negative regulation by host of viral exo-alpha-sialidase activity
GO:0044870 modulation by host of viral glycoprotein metabolic process
GO:0044871 negative regulation by host of viral glycoprotein metabolic process
GO:0045428 regulation of nitric oxide biosynthetic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045807 positive regulation of endocytosis
GO:0046209 nitric oxide metabolic process
GO:0046596 regulation of viral entry into host cell
GO:0046597 negative regulation of viral entry into host cell
GO:0046718 viral entry into host cell
GO:0048525 negative regulation of viral process
GO:0050764 regulation of phagocytosis
GO:0050766 positive regulation of phagocytosis
GO:0050792 regulation of viral process
GO:0051346 negative regulation of hydrolase activity
GO:0051701 interaction with host
GO:0051702 interaction with symbiont
GO:0051806 entry into cell of other organism involved in symbiotic interaction
GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction
GO:0051828 entry into other organism involved in symbiotic interaction
GO:0051851 modification by host of symbiont morphology or physiology
GO:0052055 modulation by symbiont of host molecular function
GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction
GO:0052203 modulation of catalytic activity in other organism involved in symbiotic interaction
GO:0052204 negative regulation of molecular function in other organism involved in symbiotic interaction
GO:0052205 modulation of molecular function in other organism involved in symbiotic interaction
GO:0052403 negative regulation by host of symbiont catalytic activity
GO:0052405 negative regulation by host of symbiont molecular function
GO:0052422 modulation by host of symbiont catalytic activity
GO:0052428 modification by host of symbiont molecular function
GO:0060627 regulation of vesicle-mediated transport
GO:0072593 reactive oxygen species metabolic process
GO:1903015 regulation of exo-alpha-sialidase activity
GO:1903016 negative regulation of exo-alpha-sialidase activity
GO:1903018 regulation of glycoprotein metabolic process
GO:1903019 negative regulation of glycoprotein metabolic process
GO:1903409 reactive oxygen species biosynthetic process
GO:1903426 regulation of reactive oxygen species biosynthetic process
GO:1903428 positive regulation of reactive oxygen species biosynthetic process
GO:1903900 regulation of viral life cycle
GO:1903901 negative regulation of viral life cycle
GO:1904407 positive regulation of nitric oxide metabolic process
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2001057 reactive nitrogen species metabolic process
Molecular Function GO:0001846 opsonin binding
GO:0001848 complement binding
GO:0001849 complement component C1q binding
GO:0001871 pattern binding
GO:0001872 (1->3)-beta-D-glucan binding
GO:0030246 carbohydrate binding
GO:0030247 polysaccharide binding
GO:0046790 virion binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-6798695: Neutrophil degranulation
Summary
SymbolPTX3
Namepentraxin 3, long
Aliases TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ......
Chromosomal Location3q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PTX3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between PTX3 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
24950910Prostate CarcinomaInhibit immunity (biomarker)In summary, our results encourage further evaluation of PTX3 as a tissue biopsy and blood-borne biomarker to discriminate BPH from prostate cancer.
23861541Nasopharyngeal CarcinomaInhibit immunityAn increase in C/EBPδ abundance in macrophages in response to PGE? resulted in enhanced production of the immunosuppressive cytokine interleukin-10 (IL-10) and of pentraxin 3 (PTX3), which suppresses the ability of macrophages to phagocytose tumor cells.
Summary
SymbolPTX3
Namepentraxin 3, long
Aliases TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ......
Chromosomal Location3q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PTX3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPTX3
Namepentraxin 3, long
Aliases TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ......
Chromosomal Location3q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PTX3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.4490.514
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.6550.607
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2860.768
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.6040.411
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.2390.304
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2070.894
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1750.76
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.6270.49
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.4010.666
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.3960.652
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.4980.17
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.220.432
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PTX3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.76.8-3.11
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.78.5-4.80.66
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPTX3
Namepentraxin 3, long
Aliases TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ......
Chromosomal Location3q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PTX3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPTX3
Namepentraxin 3, long
Aliases TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ......
Chromosomal Location3q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PTX3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PTX3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPTX3
Namepentraxin 3, long
Aliases TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ......
Chromosomal Location3q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PTX3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPTX3
Namepentraxin 3, long
Aliases TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ......
Chromosomal Location3q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PTX3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPTX3
Namepentraxin 3, long
Aliases TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ......
Chromosomal Location3q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PTX3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPTX3
Namepentraxin 3, long
Aliases TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ......
Chromosomal Location3q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PTX3 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.