Summary | |
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Symbol | PVRL2 |
Name | poliovirus receptor-related 2 (herpesvirus entry mediator B) |
Aliases | PVRR2; CD112; HVEB; herpesvirus entry protein B; poliovirus receptor-like 2; CD antigen CD112; Poliovirus re ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
Domain |
PF08205 CD80-like C2-set immunoglobulin domain PF07686 Immunoglobulin V-set domain |
Function |
Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005). ; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV). |
Biological Process |
GO:0001675 acrosome assembly GO:0001906 cell killing GO:0001909 leukocyte mediated cytotoxicity GO:0001910 regulation of leukocyte mediated cytotoxicity GO:0001912 positive regulation of leukocyte mediated cytotoxicity GO:0001913 T cell mediated cytotoxicity GO:0001914 regulation of T cell mediated cytotoxicity GO:0001916 positive regulation of T cell mediated cytotoxicity GO:0002228 natural killer cell mediated immunity GO:0002250 adaptive immune response GO:0002274 myeloid leukocyte activation GO:0002347 response to tumor cell GO:0002418 immune response to tumor cell GO:0002420 natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002423 natural killer cell mediated immune response to tumor cell GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002456 T cell mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002703 regulation of leukocyte mediated immunity GO:0002705 positive regulation of leukocyte mediated immunity GO:0002706 regulation of lymphocyte mediated immunity GO:0002708 positive regulation of lymphocyte mediated immunity GO:0002709 regulation of T cell mediated immunity GO:0002711 positive regulation of T cell mediated immunity GO:0002712 regulation of B cell mediated immunity GO:0002714 positive regulation of B cell mediated immunity GO:0002715 regulation of natural killer cell mediated immunity GO:0002717 positive regulation of natural killer cell mediated immunity GO:0002819 regulation of adaptive immune response GO:0002821 positive regulation of adaptive immune response GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002831 regulation of response to biotic stimulus GO:0002833 positive regulation of response to biotic stimulus GO:0002834 regulation of response to tumor cell GO:0002836 positive regulation of response to tumor cell GO:0002837 regulation of immune response to tumor cell GO:0002839 positive regulation of immune response to tumor cell GO:0002855 regulation of natural killer cell mediated immune response to tumor cell GO:0002857 positive regulation of natural killer cell mediated immune response to tumor cell GO:0002858 regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002889 regulation of immunoglobulin mediated immune response GO:0002891 positive regulation of immunoglobulin mediated immune response GO:0006997 nucleus organization GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007281 germ cell development GO:0007283 spermatogenesis GO:0007286 spermatid development GO:0007289 spermatid nucleus differentiation GO:0008037 cell recognition GO:0009566 fertilization GO:0010927 cellular component assembly involved in morphogenesis GO:0016050 vesicle organization GO:0016064 immunoglobulin mediated immune response GO:0019058 viral life cycle GO:0019062 virion attachment to host cell GO:0019064 fusion of virus membrane with host plasma membrane GO:0019724 B cell mediated immunity GO:0022412 cellular process involved in reproduction in multicellular organism GO:0030260 entry into host cell GO:0030382 sperm mitochondrion organization GO:0031341 regulation of cell killing GO:0031343 positive regulation of cell killing GO:0031349 positive regulation of defense response GO:0033003 regulation of mast cell activation GO:0033005 positive regulation of mast cell activation GO:0033363 secretory granule organization GO:0034330 cell junction organization GO:0034332 adherens junction organization GO:0039663 membrane fusion involved in viral entry into host cell GO:0042267 natural killer cell mediated cytotoxicity GO:0042269 regulation of natural killer cell mediated cytotoxicity GO:0042271 susceptibility to natural killer cell mediated cytotoxicity GO:0043900 regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0044406 adhesion of symbiont to host GO:0044409 entry into host GO:0044650 adhesion of symbiont to host cell GO:0044782 cilium organization GO:0044800 multi-organism membrane fusion GO:0044803 multi-organism membrane organization GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045216 cell-cell junction organization GO:0045576 mast cell activation GO:0045954 positive regulation of natural killer cell mediated cytotoxicity GO:0046596 regulation of viral entry into host cell GO:0046718 viral entry into host cell GO:0046814 coreceptor-mediated virion attachment to host cell GO:0048232 male gamete generation GO:0048515 spermatid differentiation GO:0050792 regulation of viral process GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0051640 organelle localization GO:0051646 mitochondrion localization GO:0051654 establishment of mitochondrion localization GO:0051656 establishment of organelle localization GO:0051701 interaction with host GO:0051806 entry into cell of other organism involved in symbiotic interaction GO:0051828 entry into other organism involved in symbiotic interaction GO:0060370 susceptibility to T cell mediated cytotoxicity GO:0061025 membrane fusion GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules GO:1903900 regulation of viral life cycle |
Molecular Function |
GO:0001618 virus receptor activity GO:0015026 coreceptor activity GO:0046982 protein heterodimerization activity GO:0050839 cell adhesion molecule binding |
Cellular Component |
GO:0005913 cell-cell adherens junction GO:0005915 zonula adherens GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0030055 cell-substrate junction GO:0043296 apical junction complex |
KEGG |
hsa04514 Cell adhesion molecules (CAMs) hsa04520 Adherens junction |
Reactome | - |
Summary | |
---|---|
Symbol | PVRL2 |
Name | poliovirus receptor-related 2 (herpesvirus entry mediator B) |
Aliases | PVRR2; CD112; HVEB; herpesvirus entry protein B; poliovirus receptor-like 2; CD antigen CD112; Poliovirus re ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PVRL2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PVRL2 |
Name | poliovirus receptor-related 2 (herpesvirus entry mediator B) |
Aliases | PVRR2; CD112; HVEB; herpesvirus entry protein B; poliovirus receptor-like 2; CD antigen CD112; Poliovirus re ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PVRL2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PVRL2 |
Name | poliovirus receptor-related 2 (herpesvirus entry mediator B) |
Aliases | PVRR2; CD112; HVEB; herpesvirus entry protein B; poliovirus receptor-like 2; CD antigen CD112; Poliovirus re ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PVRL2 in various data sets.
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Points in the above scatter plot represent the mutation difference of PVRL2 in various data sets.
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Summary | |
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Symbol | PVRL2 |
Name | poliovirus receptor-related 2 (herpesvirus entry mediator B) |
Aliases | PVRR2; CD112; HVEB; herpesvirus entry protein B; poliovirus receptor-like 2; CD antigen CD112; Poliovirus re ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PVRL2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PVRL2 |
Name | poliovirus receptor-related 2 (herpesvirus entry mediator B) |
Aliases | PVRR2; CD112; HVEB; herpesvirus entry protein B; poliovirus receptor-like 2; CD antigen CD112; Poliovirus re ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PVRL2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PVRL2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | PVRL2 |
Name | poliovirus receptor-related 2 (herpesvirus entry mediator B) |
Aliases | PVRR2; CD112; HVEB; herpesvirus entry protein B; poliovirus receptor-like 2; CD antigen CD112; Poliovirus re ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PVRL2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PVRL2 |
Name | poliovirus receptor-related 2 (herpesvirus entry mediator B) |
Aliases | PVRR2; CD112; HVEB; herpesvirus entry protein B; poliovirus receptor-like 2; CD antigen CD112; Poliovirus re ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PVRL2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PVRL2 |
Name | poliovirus receptor-related 2 (herpesvirus entry mediator B) |
Aliases | PVRR2; CD112; HVEB; herpesvirus entry protein B; poliovirus receptor-like 2; CD antigen CD112; Poliovirus re ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PVRL2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PVRL2 |
Name | poliovirus receptor-related 2 (herpesvirus entry mediator B) |
Aliases | PVRR2; CD112; HVEB; herpesvirus entry protein B; poliovirus receptor-like 2; CD antigen CD112; Poliovirus re ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PVRL2 collected from DrugBank database. |
There is no record. |