Summary | |
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Symbol | PXDNL |
Name | peroxidasin-like |
Aliases | FLJ25471; polysomal ribonuclease 1 homolog (Xenopus); peroxidasin homolog-like (Drosophila); peroxidasin hom ...... |
Chromosomal Location | 8q11.21-q11.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted ; SUBCELLULAR LOCATION: Isoform PMR1: Cytoplasm. Note=Associates with polysomes. |
Domain |
PF03098 Animal haem peroxidase PF07679 Immunoglobulin I-set domain PF13855 Leucine rich repeat PF00093 von Willebrand factor type C domain |
Function |
Isoform PMR1: Endonuclease selectively degrading some target mRNAs while they are engaged by translating ribosomes, among which albumin and beta-globin mRNAs. |
Biological Process |
GO:0006979 response to oxidative stress GO:0009636 response to toxic substance GO:0042743 hydrogen peroxide metabolic process GO:0042744 hydrogen peroxide catabolic process GO:0072593 reactive oxygen species metabolic process GO:0090305 nucleic acid phosphodiester bond hydrolysis GO:0098754 detoxification GO:0098869 cellular oxidant detoxification GO:1990748 cellular detoxification |
Molecular Function |
GO:0004518 nuclease activity GO:0004519 endonuclease activity GO:0004601 peroxidase activity GO:0016209 antioxidant activity GO:0016684 oxidoreductase activity, acting on peroxide as acceptor GO:0020037 heme binding GO:0046906 tetrapyrrole binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | PXDNL |
Name | peroxidasin-like |
Aliases | FLJ25471; polysomal ribonuclease 1 homolog (Xenopus); peroxidasin homolog-like (Drosophila); peroxidasin hom ...... |
Chromosomal Location | 8q11.21-q11.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PXDNL and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | PXDNL |
Name | peroxidasin-like |
Aliases | FLJ25471; polysomal ribonuclease 1 homolog (Xenopus); peroxidasin homolog-like (Drosophila); peroxidasin hom ...... |
Chromosomal Location | 8q11.21-q11.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PXDNL in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | PXDNL |
Name | peroxidasin-like |
Aliases | FLJ25471; polysomal ribonuclease 1 homolog (Xenopus); peroxidasin homolog-like (Drosophila); peroxidasin hom ...... |
Chromosomal Location | 8q11.21-q11.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PXDNL in various data sets.
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Points in the above scatter plot represent the mutation difference of PXDNL in various data sets.
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Summary | |
---|---|
Symbol | PXDNL |
Name | peroxidasin-like |
Aliases | FLJ25471; polysomal ribonuclease 1 homolog (Xenopus); peroxidasin homolog-like (Drosophila); peroxidasin hom ...... |
Chromosomal Location | 8q11.21-q11.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PXDNL. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | PXDNL |
Name | peroxidasin-like |
Aliases | FLJ25471; polysomal ribonuclease 1 homolog (Xenopus); peroxidasin homolog-like (Drosophila); peroxidasin hom ...... |
Chromosomal Location | 8q11.21-q11.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PXDNL. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PXDNL. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | PXDNL |
Name | peroxidasin-like |
Aliases | FLJ25471; polysomal ribonuclease 1 homolog (Xenopus); peroxidasin homolog-like (Drosophila); peroxidasin hom ...... |
Chromosomal Location | 8q11.21-q11.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PXDNL. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | PXDNL |
Name | peroxidasin-like |
Aliases | FLJ25471; polysomal ribonuclease 1 homolog (Xenopus); peroxidasin homolog-like (Drosophila); peroxidasin hom ...... |
Chromosomal Location | 8q11.21-q11.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PXDNL expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | PXDNL |
Name | peroxidasin-like |
Aliases | FLJ25471; polysomal ribonuclease 1 homolog (Xenopus); peroxidasin homolog-like (Drosophila); peroxidasin hom ...... |
Chromosomal Location | 8q11.21-q11.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PXDNL and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | PXDNL |
Name | peroxidasin-like |
Aliases | FLJ25471; polysomal ribonuclease 1 homolog (Xenopus); peroxidasin homolog-like (Drosophila); peroxidasin hom ...... |
Chromosomal Location | 8q11.21-q11.22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PXDNL collected from DrugBank database. |
There is no record. |