Browse QKI

Summary
SymbolQKI
NameQKI, KH domain containing, RNA binding
Aliases QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ......
Chromosomal Location6q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Cytoplasm
Domain PF00013 KH domain
PF16551 Putative nuclear localisation signal of quaking
PF16544 Homodimerisation region of STAR domain protein
Function

RNA-binding protein that plays a central role in myelinization (PubMed:16641098). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077). In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098). Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).

> Gene Ontology
 
Biological Process GO:0001570 vasculogenesis
GO:0001676 long-chain fatty acid metabolic process
GO:0006397 mRNA processing
GO:0006403 RNA localization
GO:0006417 regulation of translation
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0007272 ensheathment of neurons
GO:0007281 germ cell development
GO:0007283 spermatogenesis
GO:0007286 spermatid development
GO:0008366 axon ensheathment
GO:0008380 RNA splicing
GO:0010608 posttranscriptional regulation of gene expression
GO:0015931 nucleobase-containing compound transport
GO:0016053 organic acid biosynthetic process
GO:0017148 negative regulation of translation
GO:0022412 cellular process involved in reproduction in multicellular organism
GO:0034248 regulation of cellular amide metabolic process
GO:0034249 negative regulation of cellular amide metabolic process
GO:0042552 myelination
GO:0042692 muscle cell differentiation
GO:0042759 long-chain fatty acid biosynthetic process
GO:0043487 regulation of RNA stability
GO:0043488 regulation of mRNA stability
GO:0044283 small molecule biosynthetic process
GO:0046394 carboxylic acid biosynthetic process
GO:0048232 male gamete generation
GO:0048514 blood vessel morphogenesis
GO:0048515 spermatid differentiation
GO:0050657 nucleic acid transport
GO:0050658 RNA transport
GO:0050779 RNA destabilization
GO:0051028 mRNA transport
GO:0051236 establishment of RNA localization
GO:0061157 mRNA destabilization
GO:0061158 3'-UTR-mediated mRNA destabilization
GO:0072330 monocarboxylic acid biosynthetic process
Molecular Function GO:0003729 mRNA binding
GO:0017124 SH3 domain binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-6802957: Oncogenic MAPK signaling
R-HSA-6802952: Signaling by BRAF and RAF fusions
Summary
SymbolQKI
NameQKI, KH domain containing, RNA binding
Aliases QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ......
Chromosomal Location6q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between QKI and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolQKI
NameQKI, KH domain containing, RNA binding
Aliases QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ......
Chromosomal Location6q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of QKI in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.52 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolQKI
NameQKI, KH domain containing, RNA binding
Aliases QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ......
Chromosomal Location6q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of QKI in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1640.551
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1990.915
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.1440.912
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.3060.237
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.120.963
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.540.87
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0860.854
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1920.931
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0350.988
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.6290.644
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.5910.437
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0940.134
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of QKI in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277302.7-2.71
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275903.4-3.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolQKI
NameQKI, KH domain containing, RNA binding
Aliases QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ......
Chromosomal Location6q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of QKI. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolQKI
NameQKI, KH domain containing, RNA binding
Aliases QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ......
Chromosomal Location6q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of QKI. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by QKI.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolQKI
NameQKI, KH domain containing, RNA binding
Aliases QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ......
Chromosomal Location6q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of QKI. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolQKI
NameQKI, KH domain containing, RNA binding
Aliases QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ......
Chromosomal Location6q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of QKI expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolQKI
NameQKI, KH domain containing, RNA binding
Aliases QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ......
Chromosomal Location6q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between QKI and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolQKI
NameQKI, KH domain containing, RNA binding
Aliases QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ......
Chromosomal Location6q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting QKI collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.