Summary | |
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Symbol | QKI |
Name | QKI, KH domain containing, RNA binding |
Aliases | QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ...... |
Chromosomal Location | 6q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Cytoplasm |
Domain |
PF00013 KH domain PF16551 Putative nuclear localisation signal of quaking PF16544 Homodimerisation region of STAR domain protein |
Function |
RNA-binding protein that plays a central role in myelinization (PubMed:16641098). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077). In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098). Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity). |
Biological Process |
GO:0001570 vasculogenesis GO:0001676 long-chain fatty acid metabolic process GO:0006397 mRNA processing GO:0006403 RNA localization GO:0006417 regulation of translation GO:0006631 fatty acid metabolic process GO:0006633 fatty acid biosynthetic process GO:0007272 ensheathment of neurons GO:0007281 germ cell development GO:0007283 spermatogenesis GO:0007286 spermatid development GO:0008366 axon ensheathment GO:0008380 RNA splicing GO:0010608 posttranscriptional regulation of gene expression GO:0015931 nucleobase-containing compound transport GO:0016053 organic acid biosynthetic process GO:0017148 negative regulation of translation GO:0022412 cellular process involved in reproduction in multicellular organism GO:0034248 regulation of cellular amide metabolic process GO:0034249 negative regulation of cellular amide metabolic process GO:0042552 myelination GO:0042692 muscle cell differentiation GO:0042759 long-chain fatty acid biosynthetic process GO:0043487 regulation of RNA stability GO:0043488 regulation of mRNA stability GO:0044283 small molecule biosynthetic process GO:0046394 carboxylic acid biosynthetic process GO:0048232 male gamete generation GO:0048514 blood vessel morphogenesis GO:0048515 spermatid differentiation GO:0050657 nucleic acid transport GO:0050658 RNA transport GO:0050779 RNA destabilization GO:0051028 mRNA transport GO:0051236 establishment of RNA localization GO:0061157 mRNA destabilization GO:0061158 3'-UTR-mediated mRNA destabilization GO:0072330 monocarboxylic acid biosynthetic process |
Molecular Function |
GO:0003729 mRNA binding GO:0017124 SH3 domain binding |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-6802957: Oncogenic MAPK signaling R-HSA-6802952: Signaling by BRAF and RAF fusions |
Summary | |
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Symbol | QKI |
Name | QKI, KH domain containing, RNA binding |
Aliases | QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ...... |
Chromosomal Location | 6q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between QKI and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | QKI |
Name | QKI, KH domain containing, RNA binding |
Aliases | QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ...... |
Chromosomal Location | 6q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of QKI in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | QKI |
Name | QKI, KH domain containing, RNA binding |
Aliases | QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ...... |
Chromosomal Location | 6q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of QKI in various data sets.
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Points in the above scatter plot represent the mutation difference of QKI in various data sets.
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Summary | |
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Symbol | QKI |
Name | QKI, KH domain containing, RNA binding |
Aliases | QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ...... |
Chromosomal Location | 6q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of QKI. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | QKI |
Name | QKI, KH domain containing, RNA binding |
Aliases | QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ...... |
Chromosomal Location | 6q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of QKI. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by QKI. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | QKI |
Name | QKI, KH domain containing, RNA binding |
Aliases | QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ...... |
Chromosomal Location | 6q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of QKI. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | QKI |
Name | QKI, KH domain containing, RNA binding |
Aliases | QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ...... |
Chromosomal Location | 6q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of QKI expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | QKI |
Name | QKI, KH domain containing, RNA binding |
Aliases | QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ...... |
Chromosomal Location | 6q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between QKI and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | QKI |
Name | QKI, KH domain containing, RNA binding |
Aliases | QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ...... |
Chromosomal Location | 6q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting QKI collected from DrugBank database. |
There is no record. |