Summary | |
---|---|
Symbol | RAB13 |
Name | RAB13, member RAS oncogene family |
Aliases | GIG4; RAS-associated protein RAB13; cell growth-inhibiting gene 4 protein; growth-inhibiting gene 4 protein; ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Lipid-anchor Cytoplasmic side Cytoplasmic vesicle membrane Lipid-anchor Cytoplasmic side Cell junction, tight junction Golgi apparatus, trans-Golgi network membrane Recycling endosome membrane Cell projection, lamellipodium Note=Tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions (PubMed:8294494). Relocalizes to the leading edge of lamellipodia in migrating endothelial cells (By similarity). |
Domain |
PF00071 Ras family |
Function |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis. |
Biological Process |
GO:0001667 ameboidal-type cell migration GO:0002064 epithelial cell development GO:0006887 exocytosis GO:0006904 vesicle docking involved in exocytosis GO:0007009 plasma membrane organization GO:0007034 vacuolar transport GO:0007043 cell-cell junction assembly GO:0007548 sex differentiation GO:0008406 gonad development GO:0008584 male gonad development GO:0009306 protein secretion GO:0010631 epithelial cell migration GO:0010737 protein kinase A signaling GO:0016197 endosomal transport GO:0022406 membrane docking GO:0030865 cortical cytoskeleton organization GO:0030866 cortical actin cytoskeleton organization GO:0032456 endocytic recycling GO:0032868 response to insulin GO:0032869 cellular response to insulin stimulus GO:0034329 cell junction assembly GO:0034330 cell junction organization GO:0035767 endothelial cell chemotaxis GO:0043297 apical junction assembly GO:0043434 response to peptide hormone GO:0043542 endothelial cell migration GO:0044795 trans-Golgi network to recycling endosome transport GO:0045137 development of primary sexual characteristics GO:0045216 cell-cell junction organization GO:0046546 development of primary male sexual characteristics GO:0046661 male sex differentiation GO:0048278 vesicle docking GO:0048608 reproductive structure development GO:0060008 Sertoli cell differentiation GO:0060009 Sertoli cell development GO:0060326 cell chemotaxis GO:0061458 reproductive system development GO:0070830 bicellular tight junction assembly GO:0071375 cellular response to peptide hormone stimulus GO:0071417 cellular response to organonitrogen compound GO:0072657 protein localization to membrane GO:0072659 protein localization to plasma membrane GO:0090002 establishment of protein localization to plasma membrane GO:0090130 tissue migration GO:0090132 epithelium migration GO:0090150 establishment of protein localization to membrane GO:0097368 establishment of Sertoli cell barrier GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1902463 protein localization to cell leading edge GO:1990778 protein localization to cell periphery |
Molecular Function |
GO:0003924 GTPase activity GO:0005525 GTP binding GO:0019001 guanyl nucleotide binding GO:0032561 guanyl ribonucleotide binding GO:0034236 protein kinase A catalytic subunit binding GO:0051018 protein kinase A binding |
Cellular Component |
GO:0005802 trans-Golgi network GO:0005923 bicellular tight junction GO:0010008 endosome membrane GO:0016328 lateral plasma membrane GO:0030027 lamellipodium GO:0030139 endocytic vesicle GO:0030141 secretory granule GO:0030659 cytoplasmic vesicle membrane GO:0031252 cell leading edge GO:0031984 organelle subcompartment GO:0032593 insulin-responsive compartment GO:0043296 apical junction complex GO:0044440 endosomal part GO:0055037 recycling endosome GO:0055038 recycling endosome membrane GO:0070160 occluding junction GO:0098791 Golgi subcompartment GO:0099503 secretory vesicle |
KEGG |
hsa04530 Tight junction |
Reactome |
R-HSA-199991: Membrane Trafficking R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-8876198: RAB GEFs exchange GTP for GDP on RABs R-HSA-8873719: RAB geranylgeranylation R-HSA-1445148: Translocation of GLUT4 to the plasma membrane R-HSA-5653656: Vesicle-mediated transport |
Summary | |
---|---|
Symbol | RAB13 |
Name | RAB13, member RAS oncogene family |
Aliases | GIG4; RAS-associated protein RAB13; cell growth-inhibiting gene 4 protein; growth-inhibiting gene 4 protein; ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RAB13 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | RAB13 |
Name | RAB13, member RAS oncogene family |
Aliases | GIG4; RAS-associated protein RAB13; cell growth-inhibiting gene 4 protein; growth-inhibiting gene 4 protein; ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of RAB13 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | RAB13 |
Name | RAB13, member RAS oncogene family |
Aliases | GIG4; RAS-associated protein RAB13; cell growth-inhibiting gene 4 protein; growth-inhibiting gene 4 protein; ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RAB13 in various data sets.
|
Points in the above scatter plot represent the mutation difference of RAB13 in various data sets.
|
Summary | |
---|---|
Symbol | RAB13 |
Name | RAB13, member RAS oncogene family |
Aliases | GIG4; RAS-associated protein RAB13; cell growth-inhibiting gene 4 protein; growth-inhibiting gene 4 protein; ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RAB13. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | RAB13 |
Name | RAB13, member RAS oncogene family |
Aliases | GIG4; RAS-associated protein RAB13; cell growth-inhibiting gene 4 protein; growth-inhibiting gene 4 protein; ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RAB13. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RAB13. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | RAB13 |
Name | RAB13, member RAS oncogene family |
Aliases | GIG4; RAS-associated protein RAB13; cell growth-inhibiting gene 4 protein; growth-inhibiting gene 4 protein; ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RAB13. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | RAB13 |
Name | RAB13, member RAS oncogene family |
Aliases | GIG4; RAS-associated protein RAB13; cell growth-inhibiting gene 4 protein; growth-inhibiting gene 4 protein; ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RAB13 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | RAB13 |
Name | RAB13, member RAS oncogene family |
Aliases | GIG4; RAS-associated protein RAB13; cell growth-inhibiting gene 4 protein; growth-inhibiting gene 4 protein; ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RAB13 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | RAB13 |
Name | RAB13, member RAS oncogene family |
Aliases | GIG4; RAS-associated protein RAB13; cell growth-inhibiting gene 4 protein; growth-inhibiting gene 4 protein; ...... |
Chromosomal Location | 1q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting RAB13 collected from DrugBank database. |
There is no record. |