Browse RAB13

Summary
SymbolRAB13
NameRAB13, member RAS oncogene family
Aliases GIG4; RAS-associated protein RAB13; cell growth-inhibiting gene 4 protein; growth-inhibiting gene 4 protein; ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Lipid-anchor Cytoplasmic side Cytoplasmic vesicle membrane Lipid-anchor Cytoplasmic side Cell junction, tight junction Golgi apparatus, trans-Golgi network membrane Recycling endosome membrane Cell projection, lamellipodium Note=Tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions (PubMed:8294494). Relocalizes to the leading edge of lamellipodia in migrating endothelial cells (By similarity).
Domain PF00071 Ras family
Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis.

> Gene Ontology
 
Biological Process GO:0001667 ameboidal-type cell migration
GO:0002064 epithelial cell development
GO:0006887 exocytosis
GO:0006904 vesicle docking involved in exocytosis
GO:0007009 plasma membrane organization
GO:0007034 vacuolar transport
GO:0007043 cell-cell junction assembly
GO:0007548 sex differentiation
GO:0008406 gonad development
GO:0008584 male gonad development
GO:0009306 protein secretion
GO:0010631 epithelial cell migration
GO:0010737 protein kinase A signaling
GO:0016197 endosomal transport
GO:0022406 membrane docking
GO:0030865 cortical cytoskeleton organization
GO:0030866 cortical actin cytoskeleton organization
GO:0032456 endocytic recycling
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0034329 cell junction assembly
GO:0034330 cell junction organization
GO:0035767 endothelial cell chemotaxis
GO:0043297 apical junction assembly
GO:0043434 response to peptide hormone
GO:0043542 endothelial cell migration
GO:0044795 trans-Golgi network to recycling endosome transport
GO:0045137 development of primary sexual characteristics
GO:0045216 cell-cell junction organization
GO:0046546 development of primary male sexual characteristics
GO:0046661 male sex differentiation
GO:0048278 vesicle docking
GO:0048608 reproductive structure development
GO:0060008 Sertoli cell differentiation
GO:0060009 Sertoli cell development
GO:0060326 cell chemotaxis
GO:0061458 reproductive system development
GO:0070830 bicellular tight junction assembly
GO:0071375 cellular response to peptide hormone stimulus
GO:0071417 cellular response to organonitrogen compound
GO:0072657 protein localization to membrane
GO:0072659 protein localization to plasma membrane
GO:0090002 establishment of protein localization to plasma membrane
GO:0090130 tissue migration
GO:0090132 epithelium migration
GO:0090150 establishment of protein localization to membrane
GO:0097368 establishment of Sertoli cell barrier
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1902463 protein localization to cell leading edge
GO:1990778 protein localization to cell periphery
Molecular Function GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0032561 guanyl ribonucleotide binding
GO:0034236 protein kinase A catalytic subunit binding
GO:0051018 protein kinase A binding
Cellular Component GO:0005802 trans-Golgi network
GO:0005923 bicellular tight junction
GO:0010008 endosome membrane
GO:0016328 lateral plasma membrane
GO:0030027 lamellipodium
GO:0030139 endocytic vesicle
GO:0030141 secretory granule
GO:0030659 cytoplasmic vesicle membrane
GO:0031252 cell leading edge
GO:0031984 organelle subcompartment
GO:0032593 insulin-responsive compartment
GO:0043296 apical junction complex
GO:0044440 endosomal part
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane
GO:0070160 occluding junction
GO:0098791 Golgi subcompartment
GO:0099503 secretory vesicle
> KEGG and Reactome Pathway
 
KEGG hsa04530 Tight junction
Reactome R-HSA-199991: Membrane Trafficking
R-HSA-392499: Metabolism of proteins
R-HSA-597592: Post-translational protein modification
R-HSA-8876198: RAB GEFs exchange GTP for GDP on RABs
R-HSA-8873719: RAB geranylgeranylation
R-HSA-1445148: Translocation of GLUT4 to the plasma membrane
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolRAB13
NameRAB13, member RAS oncogene family
Aliases GIG4; RAS-associated protein RAB13; cell growth-inhibiting gene 4 protein; growth-inhibiting gene 4 protein; ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between RAB13 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolRAB13
NameRAB13, member RAS oncogene family
Aliases GIG4; RAS-associated protein RAB13; cell growth-inhibiting gene 4 protein; growth-inhibiting gene 4 protein; ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of RAB13 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -2.44; FDR: 0.04630 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolRAB13
NameRAB13, member RAS oncogene family
Aliases GIG4; RAS-associated protein RAB13; cell growth-inhibiting gene 4 protein; growth-inhibiting gene 4 protein; ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of RAB13 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.4060.167
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.6680.848
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2160.933
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0220.911
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.0011
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.0530.983
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0510.91
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.4170.828
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.3320.878
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0580.981
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.3760.919
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0090.889
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of RAB13 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolRAB13
NameRAB13, member RAS oncogene family
Aliases GIG4; RAS-associated protein RAB13; cell growth-inhibiting gene 4 protein; growth-inhibiting gene 4 protein; ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RAB13. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolRAB13
NameRAB13, member RAS oncogene family
Aliases GIG4; RAS-associated protein RAB13; cell growth-inhibiting gene 4 protein; growth-inhibiting gene 4 protein; ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RAB13. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RAB13.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolRAB13
NameRAB13, member RAS oncogene family
Aliases GIG4; RAS-associated protein RAB13; cell growth-inhibiting gene 4 protein; growth-inhibiting gene 4 protein; ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RAB13. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolRAB13
NameRAB13, member RAS oncogene family
Aliases GIG4; RAS-associated protein RAB13; cell growth-inhibiting gene 4 protein; growth-inhibiting gene 4 protein; ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of RAB13 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolRAB13
NameRAB13, member RAS oncogene family
Aliases GIG4; RAS-associated protein RAB13; cell growth-inhibiting gene 4 protein; growth-inhibiting gene 4 protein; ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between RAB13 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolRAB13
NameRAB13, member RAS oncogene family
Aliases GIG4; RAS-associated protein RAB13; cell growth-inhibiting gene 4 protein; growth-inhibiting gene 4 protein; ......
Chromosomal Location1q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting RAB13 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.