Summary | |
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Symbol | RAB1A |
Name | RAB1A, member RAS oncogene family |
Aliases | YPT1; Rab GTPase YPT1 homolog (yeast); GTP binding protein Rab1a; RAB1, member RAS oncogene family; Rab GTPa ...... |
Chromosomal Location | 2p14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Golgi apparatus Endoplasmic reticulum Early endosome Cytoplasm, cytosol Membrane Melanosome Note=Alternates between membrane-associated and cytosolic forms. |
Domain |
PF00071 Ras family |
Function |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport. |
Biological Process |
GO:0000045 autophagosome assembly GO:0002790 peptide secretion GO:0006888 ER to Golgi vesicle-mediated transport GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0006900 membrane budding GO:0006901 vesicle coating GO:0006903 vesicle targeting GO:0006914 autophagy GO:0007018 microtubule-based movement GO:0007030 Golgi organization GO:0007033 vacuole organization GO:0009100 glycoprotein metabolic process GO:0009306 protein secretion GO:0009914 hormone transport GO:0010817 regulation of hormone levels GO:0010970 transport along microtubule GO:0015833 peptide transport GO:0016050 vesicle organization GO:0016236 macroautophagy GO:0019058 viral life cycle GO:0019068 virion assembly GO:0023061 signal release GO:0030072 peptide hormone secretion GO:0030252 growth hormone secretion GO:0030705 cytoskeleton-dependent intracellular transport GO:0031589 cell-substrate adhesion GO:0032400 melanosome localization GO:0032401 establishment of melanosome localization GO:0032402 melanosome transport GO:0032637 interleukin-8 production GO:0033059 cellular pigmentation GO:0034446 substrate adhesion-dependent cell spreading GO:0035459 cargo loading into vesicle GO:0042742 defense response to bacterium GO:0042886 amide transport GO:0043473 pigmentation GO:0046879 hormone secretion GO:0047496 vesicle transport along microtubule GO:0048193 Golgi vesicle transport GO:0048199 vesicle targeting, to, from or within Golgi GO:0048207 vesicle targeting, rough ER to cis-Golgi GO:0048208 COPII vesicle coating GO:0050663 cytokine secretion GO:0051640 organelle localization GO:0051648 vesicle localization GO:0051650 establishment of vesicle localization GO:0051656 establishment of organelle localization GO:0051668 localization within membrane GO:0051875 pigment granule localization GO:0051904 pigment granule transport GO:0051905 establishment of pigment granule localization GO:0072384 organelle transport along microtubule GO:0072606 interleukin-8 secretion GO:0090110 cargo loading into COPII-coated vesicle GO:0090114 COPII-coated vesicle budding GO:0098542 defense response to other organism GO:0099518 vesicle cytoskeletal trafficking GO:1903018 regulation of glycoprotein metabolic process GO:1903020 positive regulation of glycoprotein metabolic process GO:1905037 autophagosome organization |
Molecular Function |
GO:0003924 GTPase activity GO:0005525 GTP binding GO:0019001 guanyl nucleotide binding GO:0032561 guanyl ribonucleotide binding GO:0045296 cadherin binding GO:0050839 cell adhesion molecule binding GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion |
Cellular Component |
GO:0005769 early endosome GO:0005913 cell-cell adherens junction GO:0042470 melanosome GO:0048770 pigment granule |
KEGG | - |
Reactome |
R-HSA-446203: Asparagine N-linked glycosylation R-HSA-6811434: COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6807878: COPI-mediated anterograde transport R-HSA-204005: COPII (Coat Protein 2) Mediated Vesicle Transport R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-199977: ER to Golgi Anterograde Transport R-HSA-162658: Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-8856688: Golgi-to-ER retrograde transport R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-68886: M Phase R-HSA-199991: Membrane Trafficking R-HSA-392499: Metabolism of proteins R-HSA-68875: Mitotic Prophase R-HSA-597592: Post-translational protein modification R-HSA-8876198: RAB GEFs exchange GTP for GDP on RABs R-HSA-8873719: RAB geranylgeranylation R-HSA-948021: Transport to the Golgi and subsequent modification R-HSA-5653656: Vesicle-mediated transport |
Summary | |
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Symbol | RAB1A |
Name | RAB1A, member RAS oncogene family |
Aliases | YPT1; Rab GTPase YPT1 homolog (yeast); GTP binding protein Rab1a; RAB1, member RAS oncogene family; Rab GTPa ...... |
Chromosomal Location | 2p14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RAB1A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | RAB1A |
Name | RAB1A, member RAS oncogene family |
Aliases | YPT1; Rab GTPase YPT1 homolog (yeast); GTP binding protein Rab1a; RAB1, member RAS oncogene family; Rab GTPa ...... |
Chromosomal Location | 2p14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of RAB1A in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | RAB1A |
Name | RAB1A, member RAS oncogene family |
Aliases | YPT1; Rab GTPase YPT1 homolog (yeast); GTP binding protein Rab1a; RAB1, member RAS oncogene family; Rab GTPa ...... |
Chromosomal Location | 2p14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RAB1A in various data sets.
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Points in the above scatter plot represent the mutation difference of RAB1A in various data sets.
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Summary | |
---|---|
Symbol | RAB1A |
Name | RAB1A, member RAS oncogene family |
Aliases | YPT1; Rab GTPase YPT1 homolog (yeast); GTP binding protein Rab1a; RAB1, member RAS oncogene family; Rab GTPa ...... |
Chromosomal Location | 2p14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RAB1A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | RAB1A |
Name | RAB1A, member RAS oncogene family |
Aliases | YPT1; Rab GTPase YPT1 homolog (yeast); GTP binding protein Rab1a; RAB1, member RAS oncogene family; Rab GTPa ...... |
Chromosomal Location | 2p14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RAB1A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RAB1A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | RAB1A |
Name | RAB1A, member RAS oncogene family |
Aliases | YPT1; Rab GTPase YPT1 homolog (yeast); GTP binding protein Rab1a; RAB1, member RAS oncogene family; Rab GTPa ...... |
Chromosomal Location | 2p14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RAB1A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | RAB1A |
Name | RAB1A, member RAS oncogene family |
Aliases | YPT1; Rab GTPase YPT1 homolog (yeast); GTP binding protein Rab1a; RAB1, member RAS oncogene family; Rab GTPa ...... |
Chromosomal Location | 2p14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RAB1A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | RAB1A |
Name | RAB1A, member RAS oncogene family |
Aliases | YPT1; Rab GTPase YPT1 homolog (yeast); GTP binding protein Rab1a; RAB1, member RAS oncogene family; Rab GTPa ...... |
Chromosomal Location | 2p14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RAB1A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | RAB1A |
Name | RAB1A, member RAS oncogene family |
Aliases | YPT1; Rab GTPase YPT1 homolog (yeast); GTP binding protein Rab1a; RAB1, member RAS oncogene family; Rab GTPa ...... |
Chromosomal Location | 2p14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting RAB1A collected from DrugBank database. |
There is no record. |