Summary | |
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Symbol | RAB25 |
Name | RAB25, member RAS oncogene family |
Aliases | CATX-8; RAB11C; Ras-related protein Rab-25 |
Chromosomal Location | 1q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Lipid-anchor Cytoplasmic side Cell projection, pseudopodium membrane Cytoplasmic vesicle Note=Colocalizes with integrin alpha-V/beta-1 in vesicles at the pseudopodial tips. |
Domain |
PF00071 Ras family |
Function |
Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia (PubMed:17925226). Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity). |
Biological Process |
GO:0001667 ameboidal-type cell migration GO:0002064 epithelial cell development GO:0003382 epithelial cell morphogenesis GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010634 positive regulation of epithelial cell migration GO:0030335 positive regulation of cell migration GO:0031268 pseudopodium organization GO:0040017 positive regulation of locomotion GO:0051272 positive regulation of cellular component movement GO:0060627 regulation of vesicle-mediated transport GO:0090130 tissue migration GO:0090132 epithelium migration GO:2000147 positive regulation of cell motility |
Molecular Function |
GO:0005525 GTP binding GO:0017022 myosin binding GO:0019001 guanyl nucleotide binding GO:0031489 myosin V binding GO:0032561 guanyl ribonucleotide binding |
Cellular Component |
GO:0031143 pseudopodium GO:0031253 cell projection membrane GO:0031260 pseudopodium membrane |
KEGG | - |
Reactome |
R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-8873719: RAB geranylgeranylation |
Summary | |
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Symbol | RAB25 |
Name | RAB25, member RAS oncogene family |
Aliases | CATX-8; RAB11C; Ras-related protein Rab-25 |
Chromosomal Location | 1q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RAB25 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | RAB25 |
Name | RAB25, member RAS oncogene family |
Aliases | CATX-8; RAB11C; Ras-related protein Rab-25 |
Chromosomal Location | 1q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of RAB25 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | RAB25 |
Name | RAB25, member RAS oncogene family |
Aliases | CATX-8; RAB11C; Ras-related protein Rab-25 |
Chromosomal Location | 1q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RAB25 in various data sets.
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Points in the above scatter plot represent the mutation difference of RAB25 in various data sets.
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Summary | |
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Symbol | RAB25 |
Name | RAB25, member RAS oncogene family |
Aliases | CATX-8; RAB11C; Ras-related protein Rab-25 |
Chromosomal Location | 1q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RAB25. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | RAB25 |
Name | RAB25, member RAS oncogene family |
Aliases | CATX-8; RAB11C; Ras-related protein Rab-25 |
Chromosomal Location | 1q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RAB25. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RAB25. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | RAB25 |
Name | RAB25, member RAS oncogene family |
Aliases | CATX-8; RAB11C; Ras-related protein Rab-25 |
Chromosomal Location | 1q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RAB25. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | RAB25 |
Name | RAB25, member RAS oncogene family |
Aliases | CATX-8; RAB11C; Ras-related protein Rab-25 |
Chromosomal Location | 1q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RAB25 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | RAB25 |
Name | RAB25, member RAS oncogene family |
Aliases | CATX-8; RAB11C; Ras-related protein Rab-25 |
Chromosomal Location | 1q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RAB25 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |