Browse RAB25

Summary
SymbolRAB25
NameRAB25, member RAS oncogene family
Aliases CATX-8; RAB11C; Ras-related protein Rab-25
Chromosomal Location1q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Lipid-anchor Cytoplasmic side Cell projection, pseudopodium membrane Cytoplasmic vesicle Note=Colocalizes with integrin alpha-V/beta-1 in vesicles at the pseudopodial tips.
Domain PF00071 Ras family
Function

Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia (PubMed:17925226). Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity).

> Gene Ontology
 
Biological Process GO:0001667 ameboidal-type cell migration
GO:0002064 epithelial cell development
GO:0003382 epithelial cell morphogenesis
GO:0010631 epithelial cell migration
GO:0010632 regulation of epithelial cell migration
GO:0010634 positive regulation of epithelial cell migration
GO:0030335 positive regulation of cell migration
GO:0031268 pseudopodium organization
GO:0040017 positive regulation of locomotion
GO:0051272 positive regulation of cellular component movement
GO:0060627 regulation of vesicle-mediated transport
GO:0090130 tissue migration
GO:0090132 epithelium migration
GO:2000147 positive regulation of cell motility
Molecular Function GO:0005525 GTP binding
GO:0017022 myosin binding
GO:0019001 guanyl nucleotide binding
GO:0031489 myosin V binding
GO:0032561 guanyl ribonucleotide binding
Cellular Component GO:0031143 pseudopodium
GO:0031253 cell projection membrane
GO:0031260 pseudopodium membrane
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-392499: Metabolism of proteins
R-HSA-597592: Post-translational protein modification
R-HSA-8873719: RAB geranylgeranylation
Summary
SymbolRAB25
NameRAB25, member RAS oncogene family
Aliases CATX-8; RAB11C; Ras-related protein Rab-25
Chromosomal Location1q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between RAB25 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolRAB25
NameRAB25, member RAS oncogene family
Aliases CATX-8; RAB11C; Ras-related protein Rab-25
Chromosomal Location1q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of RAB25 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -2.56; FDR: 0.04630 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolRAB25
NameRAB25, member RAS oncogene family
Aliases CATX-8; RAB11C; Ras-related protein Rab-25
Chromosomal Location1q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of RAB25 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.5910.449
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.8020.519
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)871.6190.123
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.5610.324
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.5160.762
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.6160.769
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.140.894
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0920.956
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.2860.87
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.5790.464
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.5790.588
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.2690.0991
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of RAB25 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolRAB25
NameRAB25, member RAS oncogene family
Aliases CATX-8; RAB11C; Ras-related protein Rab-25
Chromosomal Location1q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RAB25. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolRAB25
NameRAB25, member RAS oncogene family
Aliases CATX-8; RAB11C; Ras-related protein Rab-25
Chromosomal Location1q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RAB25. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RAB25.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolRAB25
NameRAB25, member RAS oncogene family
Aliases CATX-8; RAB11C; Ras-related protein Rab-25
Chromosomal Location1q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RAB25. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolRAB25
NameRAB25, member RAS oncogene family
Aliases CATX-8; RAB11C; Ras-related protein Rab-25
Chromosomal Location1q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of RAB25 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolRAB25
NameRAB25, member RAS oncogene family
Aliases CATX-8; RAB11C; Ras-related protein Rab-25
Chromosomal Location1q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between RAB25 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolRAB25
NameRAB25, member RAS oncogene family
Aliases CATX-8; RAB11C; Ras-related protein Rab-25
Chromosomal Location1q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting RAB25 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.