Browse RAB38

Summary
SymbolRAB38
NameRAB38, member RAS oncogene family
Aliases NY-MEL-1; rrGTPbp; melanoma antigen NY-MEL-1; Ras-related protein Rab-38
Chromosomal Location11q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Lipid-anchor Cytoplasmic side Melanosome Cytoplasmic vesicle, phagosome Cytoplasmic vesicle, phagosome membrane Lipid-anchor Cytoplasmic side Melanosome membrane Note=Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). The BLOC-3 complex, a heterodimer of HPS1 and HPS4 promotes its membrane localization (PubMed:23084991).
Domain PF00071 Ras family
Function

May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity).

> Gene Ontology
 
Biological Process GO:0006885 regulation of pH
GO:0007034 vacuolar transport
GO:0016050 vesicle organization
GO:0016197 endosomal transport
GO:0021700 developmental maturation
GO:0030004 cellular monovalent inorganic cation homeostasis
GO:0030641 regulation of cellular pH
GO:0032438 melanosome organization
GO:0033059 cellular pigmentation
GO:0033363 secretory granule organization
GO:0035646 endosome to melanosome transport
GO:0043473 pigmentation
GO:0043476 pigment accumulation
GO:0043482 cellular pigment accumulation
GO:0043485 endosome to pigment granule transport
GO:0045851 pH reduction
GO:0048066 developmental pigmentation
GO:0048753 pigment granule organization
GO:0048757 pigment granule maturation
GO:0050931 pigment cell differentiation
GO:0051452 intracellular pH reduction
GO:0051453 regulation of intracellular pH
GO:0055067 monovalent inorganic cation homeostasis
GO:0060155 platelet dense granule organization
GO:0072657 protein localization to membrane
GO:0090382 phagosome maturation
GO:0090383 phagosome acidification
GO:1903232 melanosome assembly
Molecular Function GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0030742 GTP-dependent protein binding
GO:0032561 guanyl ribonucleotide binding
GO:0035650 AP-1 adaptor complex binding
GO:0035651 AP-3 adaptor complex binding
GO:0036461 BLOC-2 complex binding
Cellular Component GO:0005769 early endosome
GO:0005802 trans-Golgi network
GO:0030139 endocytic vesicle
GO:0030659 cytoplasmic vesicle membrane
GO:0030666 endocytic vesicle membrane
GO:0030670 phagocytic vesicle membrane
GO:0031984 organelle subcompartment
GO:0033162 melanosome membrane
GO:0042470 melanosome
GO:0044232 organelle membrane contact site
GO:0044233 ER-mitochondrion membrane contact site
GO:0045009 chitosome
GO:0045335 phagocytic vesicle
GO:0048770 pigment granule
GO:0098791 Golgi subcompartment
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-199991: Membrane Trafficking
R-HSA-392499: Metabolism of proteins
R-HSA-597592: Post-translational protein modification
R-HSA-8876198: RAB GEFs exchange GTP for GDP on RABs
R-HSA-8873719: RAB geranylgeranylation
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolRAB38
NameRAB38, member RAS oncogene family
Aliases NY-MEL-1; rrGTPbp; melanoma antigen NY-MEL-1; Ras-related protein Rab-38
Chromosomal Location11q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between RAB38 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolRAB38
NameRAB38, member RAS oncogene family
Aliases NY-MEL-1; rrGTPbp; melanoma antigen NY-MEL-1; Ras-related protein Rab-38
Chromosomal Location11q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of RAB38 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolRAB38
NameRAB38, member RAS oncogene family
Aliases NY-MEL-1; rrGTPbp; melanoma antigen NY-MEL-1; Ras-related protein Rab-38
Chromosomal Location11q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of RAB38 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14121.2440.0192
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)651.0020.684
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)871.4140.467
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.7240.244
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.380.216
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0910.938
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-1.3140.058
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2510.887
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-2.6110.198
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1730.874
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.0750.961
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.4450.0597
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of RAB38 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolRAB38
NameRAB38, member RAS oncogene family
Aliases NY-MEL-1; rrGTPbp; melanoma antigen NY-MEL-1; Ras-related protein Rab-38
Chromosomal Location11q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RAB38. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolRAB38
NameRAB38, member RAS oncogene family
Aliases NY-MEL-1; rrGTPbp; melanoma antigen NY-MEL-1; Ras-related protein Rab-38
Chromosomal Location11q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RAB38. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RAB38.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolRAB38
NameRAB38, member RAS oncogene family
Aliases NY-MEL-1; rrGTPbp; melanoma antigen NY-MEL-1; Ras-related protein Rab-38
Chromosomal Location11q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RAB38. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolRAB38
NameRAB38, member RAS oncogene family
Aliases NY-MEL-1; rrGTPbp; melanoma antigen NY-MEL-1; Ras-related protein Rab-38
Chromosomal Location11q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of RAB38 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolRAB38
NameRAB38, member RAS oncogene family
Aliases NY-MEL-1; rrGTPbp; melanoma antigen NY-MEL-1; Ras-related protein Rab-38
Chromosomal Location11q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between RAB38 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolRAB38
NameRAB38, member RAS oncogene family
Aliases NY-MEL-1; rrGTPbp; melanoma antigen NY-MEL-1; Ras-related protein Rab-38
Chromosomal Location11q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting RAB38 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.