Browse RAB4A

Summary
SymbolRAB4A
NameRAB4A, member RAS oncogene family
Aliases HRES-1/RAB4; RAB4; Ras-related protein Rab-4A
Chromosomal Location1q42-q43
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane; Peripheral membrane protein Cytoplasm Early endosome membrane Peripheral membrane protein Recycling endosome membrane Peripheral membrane protein Note=Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1.
Domain PF00071 Ras family
Function

Protein transport. Probably involved in vesicular traffic (By similarity).

> Gene Ontology
 
Biological Process GO:0007265 Ras protein signal transduction
GO:0019882 antigen processing and presentation
GO:0030100 regulation of endocytosis
GO:0032482 Rab protein signal transduction
GO:0032781 positive regulation of ATPase activity
GO:0043462 regulation of ATPase activity
GO:0060627 regulation of vesicle-mediated transport
Molecular Function GO:0000149 SNARE binding
GO:0001671 ATPase activator activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0008047 enzyme activator activity
GO:0008565 protein transporter activity
GO:0019001 guanyl nucleotide binding
GO:0019003 GDP binding
GO:0019905 syntaxin binding
GO:0032561 guanyl ribonucleotide binding
GO:0035254 glutamate receptor binding
GO:0035255 ionotropic glutamate receptor binding
GO:0051117 ATPase binding
GO:0060589 nucleoside-triphosphatase regulator activity
GO:0060590 ATPase regulator activity
Cellular Component GO:0030141 secretory granule
GO:0032593 insulin-responsive compartment
GO:0055037 recycling endosome
GO:0099503 secretory vesicle
> KEGG and Reactome Pathway
 
KEGG hsa04144 Endocytosis
Reactome R-HSA-8875656: MET receptor recycling
R-HSA-199991: Membrane Trafficking
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-392499: Metabolism of proteins
R-HSA-1483255: PI Metabolism
R-HSA-1483257: Phospholipid metabolism
R-HSA-597592: Post-translational protein modification
R-HSA-8873719: RAB geranylgeranylation
R-HSA-162582: Signal Transduction
R-HSA-6806834: Signaling by MET
R-HSA-1660499: Synthesis of PIPs at the plasma membrane
R-HSA-8854214: TBC/RABGAPs
R-HSA-1445148: Translocation of GLUT4 to the plasma membrane
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolRAB4A
NameRAB4A, member RAS oncogene family
Aliases HRES-1/RAB4; RAB4; Ras-related protein Rab-4A
Chromosomal Location1q42-q43
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between RAB4A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolRAB4A
NameRAB4A, member RAS oncogene family
Aliases HRES-1/RAB4; RAB4; Ras-related protein Rab-4A
Chromosomal Location1q42-q43
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of RAB4A in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolRAB4A
NameRAB4A, member RAS oncogene family
Aliases HRES-1/RAB4; RAB4; Ras-related protein Rab-4A
Chromosomal Location1q42-q43
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of RAB4A in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.640.00586
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.4710.811
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.7690.573
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1910.572
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.2130.888
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1650.932
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1030.764
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2280.881
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0270.988
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0890.951
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.2810.896
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0590.405
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of RAB4A in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolRAB4A
NameRAB4A, member RAS oncogene family
Aliases HRES-1/RAB4; RAB4; Ras-related protein Rab-4A
Chromosomal Location1q42-q43
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RAB4A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolRAB4A
NameRAB4A, member RAS oncogene family
Aliases HRES-1/RAB4; RAB4; Ras-related protein Rab-4A
Chromosomal Location1q42-q43
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RAB4A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RAB4A.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolRAB4A
NameRAB4A, member RAS oncogene family
Aliases HRES-1/RAB4; RAB4; Ras-related protein Rab-4A
Chromosomal Location1q42-q43
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RAB4A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolRAB4A
NameRAB4A, member RAS oncogene family
Aliases HRES-1/RAB4; RAB4; Ras-related protein Rab-4A
Chromosomal Location1q42-q43
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of RAB4A expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolRAB4A
NameRAB4A, member RAS oncogene family
Aliases HRES-1/RAB4; RAB4; Ras-related protein Rab-4A
Chromosomal Location1q42-q43
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between RAB4A and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolRAB4A
NameRAB4A, member RAS oncogene family
Aliases HRES-1/RAB4; RAB4; Ras-related protein Rab-4A
Chromosomal Location1q42-q43
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting RAB4A collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.