Summary | |
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Symbol | RAB4A |
Name | RAB4A, member RAS oncogene family |
Aliases | HRES-1/RAB4; RAB4; Ras-related protein Rab-4A |
Chromosomal Location | 1q42-q43 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Peripheral membrane protein Cytoplasm Early endosome membrane Peripheral membrane protein Recycling endosome membrane Peripheral membrane protein Note=Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1. |
Domain |
PF00071 Ras family |
Function |
Protein transport. Probably involved in vesicular traffic (By similarity). |
Biological Process |
GO:0007265 Ras protein signal transduction GO:0019882 antigen processing and presentation GO:0030100 regulation of endocytosis GO:0032482 Rab protein signal transduction GO:0032781 positive regulation of ATPase activity GO:0043462 regulation of ATPase activity GO:0060627 regulation of vesicle-mediated transport |
Molecular Function |
GO:0000149 SNARE binding GO:0001671 ATPase activator activity GO:0003924 GTPase activity GO:0005525 GTP binding GO:0008047 enzyme activator activity GO:0008565 protein transporter activity GO:0019001 guanyl nucleotide binding GO:0019003 GDP binding GO:0019905 syntaxin binding GO:0032561 guanyl ribonucleotide binding GO:0035254 glutamate receptor binding GO:0035255 ionotropic glutamate receptor binding GO:0051117 ATPase binding GO:0060589 nucleoside-triphosphatase regulator activity GO:0060590 ATPase regulator activity |
Cellular Component |
GO:0030141 secretory granule GO:0032593 insulin-responsive compartment GO:0055037 recycling endosome GO:0099503 secretory vesicle |
KEGG |
hsa04144 Endocytosis |
Reactome |
R-HSA-8875656: MET receptor recycling R-HSA-199991: Membrane Trafficking R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-392499: Metabolism of proteins R-HSA-1483255: PI Metabolism R-HSA-1483257: Phospholipid metabolism R-HSA-597592: Post-translational protein modification R-HSA-8873719: RAB geranylgeranylation R-HSA-162582: Signal Transduction R-HSA-6806834: Signaling by MET R-HSA-1660499: Synthesis of PIPs at the plasma membrane R-HSA-8854214: TBC/RABGAPs R-HSA-1445148: Translocation of GLUT4 to the plasma membrane R-HSA-5653656: Vesicle-mediated transport |
Summary | |
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Symbol | RAB4A |
Name | RAB4A, member RAS oncogene family |
Aliases | HRES-1/RAB4; RAB4; Ras-related protein Rab-4A |
Chromosomal Location | 1q42-q43 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RAB4A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | RAB4A |
Name | RAB4A, member RAS oncogene family |
Aliases | HRES-1/RAB4; RAB4; Ras-related protein Rab-4A |
Chromosomal Location | 1q42-q43 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of RAB4A in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | RAB4A |
Name | RAB4A, member RAS oncogene family |
Aliases | HRES-1/RAB4; RAB4; Ras-related protein Rab-4A |
Chromosomal Location | 1q42-q43 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RAB4A in various data sets.
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Points in the above scatter plot represent the mutation difference of RAB4A in various data sets.
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Summary | |
---|---|
Symbol | RAB4A |
Name | RAB4A, member RAS oncogene family |
Aliases | HRES-1/RAB4; RAB4; Ras-related protein Rab-4A |
Chromosomal Location | 1q42-q43 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RAB4A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | RAB4A |
Name | RAB4A, member RAS oncogene family |
Aliases | HRES-1/RAB4; RAB4; Ras-related protein Rab-4A |
Chromosomal Location | 1q42-q43 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RAB4A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RAB4A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | RAB4A |
Name | RAB4A, member RAS oncogene family |
Aliases | HRES-1/RAB4; RAB4; Ras-related protein Rab-4A |
Chromosomal Location | 1q42-q43 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RAB4A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | RAB4A |
Name | RAB4A, member RAS oncogene family |
Aliases | HRES-1/RAB4; RAB4; Ras-related protein Rab-4A |
Chromosomal Location | 1q42-q43 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RAB4A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | RAB4A |
Name | RAB4A, member RAS oncogene family |
Aliases | HRES-1/RAB4; RAB4; Ras-related protein Rab-4A |
Chromosomal Location | 1q42-q43 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RAB4A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |