Browse RAD21

Summary
SymbolRAD21
NameRAD21 cohesin complex component
Aliases KIAA0078; hHR21; sister chromatid cohesion 1; kleisin; RAD21 (S. pombe) homolog; RAD21 homolog (S. pombe); C ......
Chromosomal Location8q24.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Chromosome Chromosome, centromere Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, it is cleaved by separase/ESPL1, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. Once cleaved by caspase-3, the C-terminal 64 kDa cleavage product translocates to the cytoplasm, where it may trigger apoptosis.
Domain PF04824 Conserved region of Rad21 / Rec8 like protein
PF04825 N terminus of Rad21 / Rec8 like protein
Function

Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.

> Gene Ontology
 
Biological Process GO:0000070 mitotic sister chromatid segregation
GO:0000819 sister chromatid segregation
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0007059 chromosome segregation
GO:0007062 sister chromatid cohesion
GO:0007064 mitotic sister chromatid cohesion
GO:0007067 mitotic nuclear division
GO:0007126 meiotic nuclear division
GO:0007127 meiosis I
GO:0007131 reciprocal meiotic recombination
GO:0007135 meiosis II
GO:0016925 protein sumoylation
GO:0018205 peptidyl-lysine modification
GO:0034502 protein localization to chromosome
GO:0035825 reciprocal DNA recombination
GO:0045132 meiotic chromosome segregation
GO:0045144 meiotic sister chromatid segregation
GO:0051177 meiotic sister chromatid cohesion
GO:0051321 meiotic cell cycle
GO:0051754 meiotic sister chromatid cohesion, centromeric
GO:0070192 chromosome organization involved in meiotic cell cycle
GO:0070601 centromeric sister chromatid cohesion
GO:0071168 protein localization to chromatin
GO:0098813 nuclear chromosome segregation
GO:1903046 meiotic cell cycle process
Molecular Function GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003682 chromatin binding
Cellular Component GO:0000775 chromosome, centromeric region
GO:0000785 chromatin
GO:0000793 condensed chromosome
GO:0000794 condensed nuclear chromosome
GO:0000798 nuclear cohesin complex
GO:0008278 cohesin complex
GO:0030893 meiotic cohesin complex
GO:0034991 nuclear meiotic cohesin complex
GO:0044454 nuclear chromosome part
GO:0098687 chromosomal region
> KEGG and Reactome Pathway
 
KEGG hsa04110 Cell cycle
Reactome R-HSA-1640170: Cell Cycle
R-HSA-69278: Cell Cycle, Mitotic
R-HSA-2470946: Cohesin Loading onto Chromatin
R-HSA-2468052: Establishment of Sister Chromatid Cohesion
R-HSA-68886: M Phase
R-HSA-1500620: Meiosis
R-HSA-1221632: Meiotic synapsis
R-HSA-392499: Metabolism of proteins
R-HSA-68882: Mitotic Anaphase
R-HSA-2555396: Mitotic Metaphase and Anaphase
R-HSA-68877: Mitotic Prometaphase
R-HSA-68884: Mitotic Telophase/Cytokinesis
R-HSA-597592: Post-translational protein modification
R-HSA-2500257: Resolution of Sister Chromatid Cohesion
R-HSA-69242: S Phase
R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins
R-HSA-2990846: SUMOylation
R-HSA-3108214: SUMOylation of DNA damage response and repair proteins
R-HSA-2467813: Separation of Sister Chromatids
Summary
SymbolRAD21
NameRAD21 cohesin complex component
Aliases KIAA0078; hHR21; sister chromatid cohesion 1; kleisin; RAD21 (S. pombe) homolog; RAD21 homolog (S. pombe); C ......
Chromosomal Location8q24.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between RAD21 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolRAD21
NameRAD21 cohesin complex component
Aliases KIAA0078; hHR21; sister chromatid cohesion 1; kleisin; RAD21 (S. pombe) homolog; RAD21 homolog (S. pombe); C ......
Chromosomal Location8q24.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of RAD21 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.61 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolRAD21
NameRAD21 cohesin complex component
Aliases KIAA0078; hHR21; sister chromatid cohesion 1; kleisin; RAD21 (S. pombe) homolog; RAD21 homolog (S. pombe); C ......
Chromosomal Location8q24.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of RAD21 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1890.434
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.4680.857
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0110.996
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.260.501
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.2210.916
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3130.909
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0480.923
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1610.944
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.090.972
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1720.917
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6920.784
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.2020.00783
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of RAD21 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.42.74.70.294
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.43.440.587
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolRAD21
NameRAD21 cohesin complex component
Aliases KIAA0078; hHR21; sister chromatid cohesion 1; kleisin; RAD21 (S. pombe) homolog; RAD21 homolog (S. pombe); C ......
Chromosomal Location8q24.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RAD21. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolRAD21
NameRAD21 cohesin complex component
Aliases KIAA0078; hHR21; sister chromatid cohesion 1; kleisin; RAD21 (S. pombe) homolog; RAD21 homolog (S. pombe); C ......
Chromosomal Location8q24.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RAD21. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RAD21.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolRAD21
NameRAD21 cohesin complex component
Aliases KIAA0078; hHR21; sister chromatid cohesion 1; kleisin; RAD21 (S. pombe) homolog; RAD21 homolog (S. pombe); C ......
Chromosomal Location8q24.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RAD21. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolRAD21
NameRAD21 cohesin complex component
Aliases KIAA0078; hHR21; sister chromatid cohesion 1; kleisin; RAD21 (S. pombe) homolog; RAD21 homolog (S. pombe); C ......
Chromosomal Location8q24.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of RAD21 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolRAD21
NameRAD21 cohesin complex component
Aliases KIAA0078; hHR21; sister chromatid cohesion 1; kleisin; RAD21 (S. pombe) homolog; RAD21 homolog (S. pombe); C ......
Chromosomal Location8q24.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between RAD21 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolRAD21
NameRAD21 cohesin complex component
Aliases KIAA0078; hHR21; sister chromatid cohesion 1; kleisin; RAD21 (S. pombe) homolog; RAD21 homolog (S. pombe); C ......
Chromosomal Location8q24.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting RAD21 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.