Summary | |
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Symbol | RAD21L1 |
Name | RAD21 cohesin complex component like 1 |
Aliases | dJ545L17.2; RAD21L; RAD21-like 1 (S. pombe); RAD21-like 1; Double-strand-break repair protein rad21-like pro ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Chromosome Note=In meiotic chromosomes, localized along axial elements in early meiosis: detectable on the axial elements in leptotene, and stays on the axial/lateral elements until mid pachytene. It then disappears and is replaced with RAD21. Compared to REC8, has mutually exclusive loading sites on the chromosomes: REC8 and RAD21L form distinct cohesin-enriched domains along the axial elements. |
Domain |
PF04824 Conserved region of Rad21 / Rec8 like protein PF04825 N terminus of Rad21 / Rec8 like protein |
Function |
Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I (By similarity). |
Biological Process |
GO:0000070 mitotic sister chromatid segregation GO:0000724 double-strand break repair via homologous recombination GO:0000725 recombinational repair GO:0000819 sister chromatid segregation GO:0006302 double-strand break repair GO:0006310 DNA recombination GO:0007059 chromosome segregation GO:0007062 sister chromatid cohesion GO:0007064 mitotic sister chromatid cohesion GO:0007067 mitotic nuclear division GO:0007126 meiotic nuclear division GO:0007127 meiosis I GO:0007129 synapsis GO:0007130 synaptonemal complex assembly GO:0007135 meiosis II GO:0007283 spermatogenesis GO:0007548 sex differentiation GO:0008406 gonad development GO:0008584 male gonad development GO:0009566 fertilization GO:0034397 telomere localization GO:0034398 telomere tethering at nuclear periphery GO:0044821 meiotic telomere tethering at nuclear periphery GO:0045132 meiotic chromosome segregation GO:0045137 development of primary sexual characteristics GO:0045141 meiotic telomere clustering GO:0045143 homologous chromosome segregation GO:0045144 meiotic sister chromatid segregation GO:0046546 development of primary male sexual characteristics GO:0046661 male sex differentiation GO:0048232 male gamete generation GO:0048608 reproductive structure development GO:0050000 chromosome localization GO:0051177 meiotic sister chromatid cohesion GO:0051303 establishment of chromosome localization GO:0051321 meiotic cell cycle GO:0051640 organelle localization GO:0051656 establishment of organelle localization GO:0051754 meiotic sister chromatid cohesion, centromeric GO:0061458 reproductive system development GO:0070192 chromosome organization involved in meiotic cell cycle GO:0070193 synaptonemal complex organization GO:0070197 meiotic attachment of telomere to nuclear envelope GO:0070601 centromeric sister chromatid cohesion GO:0072520 seminiferous tubule development GO:0090220 chromosome localization to nuclear envelope involved in homologous chromosome segregation GO:0097240 chromosome attachment to the nuclear envelope GO:0098813 nuclear chromosome segregation GO:1903046 meiotic cell cycle process |
Molecular Function |
GO:0003682 chromatin binding |
Cellular Component |
GO:0000793 condensed chromosome GO:0000794 condensed nuclear chromosome GO:0000795 synaptonemal complex GO:0000798 nuclear cohesin complex GO:0000800 lateral element GO:0008278 cohesin complex GO:0030893 meiotic cohesin complex GO:0034991 nuclear meiotic cohesin complex GO:0044454 nuclear chromosome part |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | RAD21L1 |
Name | RAD21 cohesin complex component like 1 |
Aliases | dJ545L17.2; RAD21L; RAD21-like 1 (S. pombe); RAD21-like 1; Double-strand-break repair protein rad21-like pro ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RAD21L1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | RAD21L1 |
Name | RAD21 cohesin complex component like 1 |
Aliases | dJ545L17.2; RAD21L; RAD21-like 1 (S. pombe); RAD21-like 1; Double-strand-break repair protein rad21-like pro ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of RAD21L1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | RAD21L1 |
Name | RAD21 cohesin complex component like 1 |
Aliases | dJ545L17.2; RAD21L; RAD21-like 1 (S. pombe); RAD21-like 1; Double-strand-break repair protein rad21-like pro ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RAD21L1 in various data sets.
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Points in the above scatter plot represent the mutation difference of RAD21L1 in various data sets.
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Summary | |
---|---|
Symbol | RAD21L1 |
Name | RAD21 cohesin complex component like 1 |
Aliases | dJ545L17.2; RAD21L; RAD21-like 1 (S. pombe); RAD21-like 1; Double-strand-break repair protein rad21-like pro ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RAD21L1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | RAD21L1 |
Name | RAD21 cohesin complex component like 1 |
Aliases | dJ545L17.2; RAD21L; RAD21-like 1 (S. pombe); RAD21-like 1; Double-strand-break repair protein rad21-like pro ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RAD21L1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RAD21L1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | RAD21L1 |
Name | RAD21 cohesin complex component like 1 |
Aliases | dJ545L17.2; RAD21L; RAD21-like 1 (S. pombe); RAD21-like 1; Double-strand-break repair protein rad21-like pro ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RAD21L1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | RAD21L1 |
Name | RAD21 cohesin complex component like 1 |
Aliases | dJ545L17.2; RAD21L; RAD21-like 1 (S. pombe); RAD21-like 1; Double-strand-break repair protein rad21-like pro ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RAD21L1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | RAD21L1 |
Name | RAD21 cohesin complex component like 1 |
Aliases | dJ545L17.2; RAD21L; RAD21-like 1 (S. pombe); RAD21-like 1; Double-strand-break repair protein rad21-like pro ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RAD21L1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | RAD21L1 |
Name | RAD21 cohesin complex component like 1 |
Aliases | dJ545L17.2; RAD21L; RAD21-like 1 (S. pombe); RAD21-like 1; Double-strand-break repair protein rad21-like pro ...... |
Chromosomal Location | 20p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting RAD21L1 collected from DrugBank database. |
There is no record. |