Browse RAD51D

Summary
SymbolRAD51D
NameRAD51 paralog D
Aliases HsTRAD; DNA repair protein RAD51 homolog 4; RAD51L3; RAD51 (S. cerevisiae)-like 3; RAD51-like 3 (S. cerevisi ......
Chromosomal Location17q11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, telomere.
Domain PF08423 Rad51
Function

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM.

> Gene Ontology
 
Biological Process GO:0000707 meiotic DNA recombinase assembly
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0000725 recombinational repair
GO:0000730 DNA recombinase assembly
GO:0000731 DNA synthesis involved in DNA repair
GO:0000732 strand displacement
GO:0006289 nucleotide-excision repair
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0006312 mitotic recombination
GO:0007126 meiotic nuclear division
GO:0007127 meiosis I
GO:0007131 reciprocal meiotic recombination
GO:0009314 response to radiation
GO:0010212 response to ionizing radiation
GO:0032200 telomere organization
GO:0035825 reciprocal DNA recombination
GO:0036297 interstrand cross-link repair
GO:0042148 strand invasion
GO:0045003 double-strand break repair via synthesis-dependent strand annealing
GO:0051321 meiotic cell cycle
GO:0060249 anatomical structure homeostasis
GO:0065004 protein-DNA complex assembly
GO:0071824 protein-DNA complex subunit organization
GO:0071897 DNA biosynthetic process
GO:1903046 meiotic cell cycle process
Molecular Function GO:0000150 recombinase activity
GO:0000217 DNA secondary structure binding
GO:0000400 four-way junction DNA binding
GO:0003697 single-stranded DNA binding
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0004520 endodeoxyribonuclease activity
GO:0004536 deoxyribonuclease activity
GO:0008094 DNA-dependent ATPase activity
GO:0015631 tubulin binding
GO:0016887 ATPase activity
GO:0042623 ATPase activity, coupled
GO:0043015 gamma-tubulin binding
GO:0043566 structure-specific DNA binding
Cellular Component GO:0000781 chromosome, telomeric region
GO:0000784 nuclear chromosome, telomeric region
GO:0005657 replication fork
GO:0005813 centrosome
GO:0033061 DNA recombinase mediator complex
GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex
GO:0044454 nuclear chromosome part
GO:0098687 chromosomal region
> KEGG and Reactome Pathway
 
KEGG hsa03440 Homologous recombination
Reactome R-HSA-5693532: DNA Double-Strand Break Repair
R-HSA-73894: DNA Repair
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-5693567: HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)
R-HSA-5685942: HDR through Homologous Recombination (HRR)
R-HSA-5693579: Homologous DNA Pairing and Strand Exchange
R-HSA-5693538: Homology Directed Repair
R-HSA-5693616: Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-5693537: Resolution of D-Loop Structures
R-HSA-5693568: Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-5693554: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-HSA-6796648: TP53 Regulates Transcription of DNA Repair Genes
R-HSA-3700989: Transcriptional Regulation by TP53
Summary
SymbolRAD51D
NameRAD51 paralog D
Aliases HsTRAD; DNA repair protein RAD51 homolog 4; RAD51L3; RAD51 (S. cerevisiae)-like 3; RAD51-like 3 (S. cerevisi ......
Chromosomal Location17q11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between RAD51D and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolRAD51D
NameRAD51 paralog D
Aliases HsTRAD; DNA repair protein RAD51 homolog 4; RAD51L3; RAD51 (S. cerevisiae)-like 3; RAD51-like 3 (S. cerevisi ......
Chromosomal Location17q11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of RAD51D in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: -2.39; FDR: 0.01670 Resistant to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolRAD51D
NameRAD51 paralog D
Aliases HsTRAD; DNA repair protein RAD51 homolog 4; RAD51L3; RAD51 (S. cerevisiae)-like 3; RAD51-like 3 (S. cerevisi ......
Chromosomal Location17q11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of RAD51D in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2440.158
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.4070.709
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.1220.885
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3650.171
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.4040.756
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.320.85
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1310.572
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0580.945
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.3620.704
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.5510.592
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.2130.881
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0210.718
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of RAD51D in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolRAD51D
NameRAD51 paralog D
Aliases HsTRAD; DNA repair protein RAD51 homolog 4; RAD51L3; RAD51 (S. cerevisiae)-like 3; RAD51-like 3 (S. cerevisi ......
Chromosomal Location17q11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RAD51D. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolRAD51D
NameRAD51 paralog D
Aliases HsTRAD; DNA repair protein RAD51 homolog 4; RAD51L3; RAD51 (S. cerevisiae)-like 3; RAD51-like 3 (S. cerevisi ......
Chromosomal Location17q11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RAD51D. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RAD51D.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolRAD51D
NameRAD51 paralog D
Aliases HsTRAD; DNA repair protein RAD51 homolog 4; RAD51L3; RAD51 (S. cerevisiae)-like 3; RAD51-like 3 (S. cerevisi ......
Chromosomal Location17q11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RAD51D. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolRAD51D
NameRAD51 paralog D
Aliases HsTRAD; DNA repair protein RAD51 homolog 4; RAD51L3; RAD51 (S. cerevisiae)-like 3; RAD51-like 3 (S. cerevisi ......
Chromosomal Location17q11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of RAD51D expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolRAD51D
NameRAD51 paralog D
Aliases HsTRAD; DNA repair protein RAD51 homolog 4; RAD51L3; RAD51 (S. cerevisiae)-like 3; RAD51-like 3 (S. cerevisi ......
Chromosomal Location17q11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between RAD51D and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolRAD51D
NameRAD51 paralog D
Aliases HsTRAD; DNA repair protein RAD51 homolog 4; RAD51L3; RAD51 (S. cerevisiae)-like 3; RAD51-like 3 (S. cerevisi ......
Chromosomal Location17q11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting RAD51D collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.