Summary | |
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Symbol | RAET1E |
Name | retinoic acid early transcript 1E |
Aliases | LETAL; bA350J20.7; ULBP4; N2DL-4; NKG2DL42; RL-4; RAE-1-like transcript 4; lymphocyte effector toxicity acti ...... |
Chromosomal Location | 6q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 4: Secreted. |
Domain |
PF00129 Class I Histocompatibility antigen |
Function |
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. |
Biological Process |
GO:0001906 cell killing GO:0001909 leukocyte mediated cytotoxicity GO:0001913 T cell mediated cytotoxicity GO:0002228 natural killer cell mediated immunity GO:0002250 adaptive immune response GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002456 T cell mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0019882 antigen processing and presentation GO:0042267 natural killer cell mediated cytotoxicity |
Molecular Function |
GO:0003823 antigen binding GO:0046703 natural killer cell lectin-like receptor binding |
Cellular Component | - |
KEGG |
hsa04650 Natural killer cell mediated cytotoxicity |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-168256: Immune System R-HSA-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Summary | |
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Symbol | RAET1E |
Name | retinoic acid early transcript 1E |
Aliases | LETAL; bA350J20.7; ULBP4; N2DL-4; NKG2DL42; RL-4; RAE-1-like transcript 4; lymphocyte effector toxicity acti ...... |
Chromosomal Location | 6q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RAET1E and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between RAET1E and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | RAET1E |
Name | retinoic acid early transcript 1E |
Aliases | LETAL; bA350J20.7; ULBP4; N2DL-4; NKG2DL42; RL-4; RAE-1-like transcript 4; lymphocyte effector toxicity acti ...... |
Chromosomal Location | 6q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of RAET1E in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | RAET1E |
Name | retinoic acid early transcript 1E |
Aliases | LETAL; bA350J20.7; ULBP4; N2DL-4; NKG2DL42; RL-4; RAE-1-like transcript 4; lymphocyte effector toxicity acti ...... |
Chromosomal Location | 6q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RAET1E in various data sets.
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Points in the above scatter plot represent the mutation difference of RAET1E in various data sets.
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Summary | |
---|---|
Symbol | RAET1E |
Name | retinoic acid early transcript 1E |
Aliases | LETAL; bA350J20.7; ULBP4; N2DL-4; NKG2DL42; RL-4; RAE-1-like transcript 4; lymphocyte effector toxicity acti ...... |
Chromosomal Location | 6q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RAET1E. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | RAET1E |
Name | retinoic acid early transcript 1E |
Aliases | LETAL; bA350J20.7; ULBP4; N2DL-4; NKG2DL42; RL-4; RAE-1-like transcript 4; lymphocyte effector toxicity acti ...... |
Chromosomal Location | 6q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RAET1E. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RAET1E. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | RAET1E |
Name | retinoic acid early transcript 1E |
Aliases | LETAL; bA350J20.7; ULBP4; N2DL-4; NKG2DL42; RL-4; RAE-1-like transcript 4; lymphocyte effector toxicity acti ...... |
Chromosomal Location | 6q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RAET1E. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | RAET1E |
Name | retinoic acid early transcript 1E |
Aliases | LETAL; bA350J20.7; ULBP4; N2DL-4; NKG2DL42; RL-4; RAE-1-like transcript 4; lymphocyte effector toxicity acti ...... |
Chromosomal Location | 6q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RAET1E expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | RAET1E |
Name | retinoic acid early transcript 1E |
Aliases | LETAL; bA350J20.7; ULBP4; N2DL-4; NKG2DL42; RL-4; RAE-1-like transcript 4; lymphocyte effector toxicity acti ...... |
Chromosomal Location | 6q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RAET1E and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | RAET1E |
Name | retinoic acid early transcript 1E |
Aliases | LETAL; bA350J20.7; ULBP4; N2DL-4; NKG2DL42; RL-4; RAE-1-like transcript 4; lymphocyte effector toxicity acti ...... |
Chromosomal Location | 6q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting RAET1E collected from DrugBank database. |
There is no record. |