Summary | |
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Symbol | RAET1G |
Name | retinoic acid early transcript 1G |
Aliases | ULBP5; retinoic acid early transcript 1G pseudogene; UL-16 binding protein 5; Retinoic acid early transcript ...... |
Chromosomal Location | 6q24.1-25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Cell membrane Lipid-anchor, GPI-anchor Endoplasmic reticulum Note=Mainly found intracellularly. ; SUBCELLULAR LOCATION: Isoform 2: Secreted |
Domain |
PF00129 Class I Histocompatibility antigen |
Function |
Isoform 1: Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. ; FUNCTION: Isoform 3: Down-regulates the expression of KLRK1 and stimulates natural killer cells to secrete IFNG. ; FUNCTION: Isoform 2: Stimulates natural killer cells to secrete IFNG. |
Biological Process |
GO:0001906 cell killing GO:0001909 leukocyte mediated cytotoxicity GO:0002228 natural killer cell mediated immunity GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0019882 antigen processing and presentation GO:0042267 natural killer cell mediated cytotoxicity |
Molecular Function |
GO:0003823 antigen binding GO:0046703 natural killer cell lectin-like receptor binding |
Cellular Component |
GO:0031225 anchored component of membrane |
KEGG |
hsa04650 Natural killer cell mediated cytotoxicity |
Reactome |
R-HSA-392499: Metabolism of proteins R-HSA-163125: Post-translational modification R-HSA-597592: Post-translational protein modification |
Summary | |
---|---|
Symbol | RAET1G |
Name | retinoic acid early transcript 1G |
Aliases | ULBP5; retinoic acid early transcript 1G pseudogene; UL-16 binding protein 5; Retinoic acid early transcript ...... |
Chromosomal Location | 6q24.1-25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RAET1G and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between RAET1G and anti-tumor immunity in human cancer.
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Summary | |
---|---|
Symbol | RAET1G |
Name | retinoic acid early transcript 1G |
Aliases | ULBP5; retinoic acid early transcript 1G pseudogene; UL-16 binding protein 5; Retinoic acid early transcript ...... |
Chromosomal Location | 6q24.1-25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of RAET1G in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | RAET1G |
Name | retinoic acid early transcript 1G |
Aliases | ULBP5; retinoic acid early transcript 1G pseudogene; UL-16 binding protein 5; Retinoic acid early transcript ...... |
Chromosomal Location | 6q24.1-25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RAET1G in various data sets.
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Points in the above scatter plot represent the mutation difference of RAET1G in various data sets.
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Summary | |
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Symbol | RAET1G |
Name | retinoic acid early transcript 1G |
Aliases | ULBP5; retinoic acid early transcript 1G pseudogene; UL-16 binding protein 5; Retinoic acid early transcript ...... |
Chromosomal Location | 6q24.1-25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RAET1G. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | RAET1G |
Name | retinoic acid early transcript 1G |
Aliases | ULBP5; retinoic acid early transcript 1G pseudogene; UL-16 binding protein 5; Retinoic acid early transcript ...... |
Chromosomal Location | 6q24.1-25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RAET1G. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RAET1G. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | RAET1G |
Name | retinoic acid early transcript 1G |
Aliases | ULBP5; retinoic acid early transcript 1G pseudogene; UL-16 binding protein 5; Retinoic acid early transcript ...... |
Chromosomal Location | 6q24.1-25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RAET1G. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | RAET1G |
Name | retinoic acid early transcript 1G |
Aliases | ULBP5; retinoic acid early transcript 1G pseudogene; UL-16 binding protein 5; Retinoic acid early transcript ...... |
Chromosomal Location | 6q24.1-25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RAET1G expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | RAET1G |
Name | retinoic acid early transcript 1G |
Aliases | ULBP5; retinoic acid early transcript 1G pseudogene; UL-16 binding protein 5; Retinoic acid early transcript ...... |
Chromosomal Location | 6q24.1-25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RAET1G and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | RAET1G |
Name | retinoic acid early transcript 1G |
Aliases | ULBP5; retinoic acid early transcript 1G pseudogene; UL-16 binding protein 5; Retinoic acid early transcript ...... |
Chromosomal Location | 6q24.1-25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting RAET1G collected from DrugBank database. |
There is no record. |