Summary | |
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Symbol | RAP1A |
Name | RAP1A, member of RAS oncogene family |
Aliases | KREV-1; SMGP21; C21KG; G-22K; KREV1; GTP-binding protein smg p21A; Ras-related protein Krev-1; Ras-related p ...... |
Chromosomal Location | 1p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Lipid-anchor Cytoplasm Cytoplasm, perinuclear region Cell junction Early endosome Note=Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Localized with RAPGEF2 at cell-cell junctions (By similarity). Colocalized with RAPGEF2 in the perinuclear region. |
Domain |
PF00071 Ras family |
Function |
Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. |
Biological Process |
GO:0000186 activation of MAPKK activity GO:0001505 regulation of neurotransmitter levels GO:0001570 vasculogenesis GO:0001678 cellular glucose homeostasis GO:0001885 endothelial cell development GO:0001889 liver development GO:0002064 epithelial cell development GO:0002790 peptide secretion GO:0002791 regulation of peptide secretion GO:0003158 endothelium development GO:0006836 neurotransmitter transport GO:0006887 exocytosis GO:0006909 phagocytosis GO:0007265 Ras protein signal transduction GO:0007269 neurotransmitter secretion GO:0008643 carbohydrate transport GO:0008645 hexose transport GO:0009306 protein secretion GO:0009743 response to carbohydrate GO:0009746 response to hexose GO:0009749 response to glucose GO:0009914 hormone transport GO:0010712 regulation of collagen metabolic process GO:0010713 negative regulation of collagen metabolic process GO:0010720 positive regulation of cell development GO:0010817 regulation of hormone levels GO:0010827 regulation of glucose transport GO:0010828 positive regulation of glucose transport GO:0010975 regulation of neuron projection development GO:0010976 positive regulation of neuron projection development GO:0014074 response to purine-containing compound GO:0015749 monosaccharide transport GO:0015758 glucose transport GO:0015833 peptide transport GO:0016079 synaptic vesicle exocytosis GO:0017156 calcium ion regulated exocytosis GO:0017157 regulation of exocytosis GO:0017158 regulation of calcium ion-dependent exocytosis GO:0023061 signal release GO:0030072 peptide hormone secretion GO:0030073 insulin secretion GO:0030100 regulation of endocytosis GO:0031099 regeneration GO:0031100 animal organ regeneration GO:0031346 positive regulation of cell projection organization GO:0032147 activation of protein kinase activity GO:0032486 Rap protein signal transduction GO:0032963 collagen metabolic process GO:0032964 collagen biosynthetic process GO:0032965 regulation of collagen biosynthetic process GO:0032966 negative regulation of collagen biosynthetic process GO:0033500 carbohydrate homeostasis GO:0033674 positive regulation of kinase activity GO:0034284 response to monosaccharide GO:0034329 cell junction assembly GO:0034330 cell junction organization GO:0035690 cellular response to drug GO:0038179 neurotrophin signaling pathway GO:0038180 nerve growth factor signaling pathway GO:0042493 response to drug GO:0042593 glucose homeostasis GO:0042886 amide transport GO:0043405 regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0044236 multicellular organism metabolic process GO:0044246 regulation of multicellular organismal metabolic process GO:0044252 negative regulation of multicellular organismal metabolic process GO:0044259 multicellular organismal macromolecule metabolic process GO:0045055 regulated exocytosis GO:0045446 endothelial cell differentiation GO:0045666 positive regulation of neuron differentiation GO:0045807 positive regulation of endocytosis GO:0045860 positive regulation of protein kinase activity GO:0045920 negative regulation of exocytosis GO:0045955 negative regulation of calcium ion-dependent exocytosis GO:0046323 glucose import GO:0046324 regulation of glucose import GO:0046326 positive regulation of glucose import GO:0046683 response to organophosphorus GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0046928 regulation of neurotransmitter secretion GO:0046929 negative regulation of neurotransmitter secretion GO:0048489 synaptic vesicle transport GO:0048514 blood vessel morphogenesis GO:0048732 gland development GO:0050708 regulation of protein secretion GO:0050764 regulation of phagocytosis GO:0050766 positive regulation of phagocytosis GO:0050769 positive regulation of neurogenesis GO:0050796 regulation of insulin secretion GO:0050804 modulation of synaptic transmission GO:0050805 negative regulation of synaptic transmission GO:0051048 negative regulation of secretion GO:0051051 negative regulation of transport GO:0051588 regulation of neurotransmitter transport GO:0051589 negative regulation of neurotransmitter transport GO:0051591 response to cAMP GO:0051640 organelle localization GO:0051648 vesicle localization GO:0051650 establishment of vesicle localization GO:0051656 establishment of organelle localization GO:0051962 positive regulation of nervous system development GO:0060627 regulation of vesicle-mediated transport GO:0061008 hepaticobiliary system development GO:0061028 establishment of endothelial barrier GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0071320 cellular response to cAMP GO:0071322 cellular response to carbohydrate stimulus GO:0071326 cellular response to monosaccharide stimulus GO:0071331 cellular response to hexose stimulus GO:0071333 cellular response to glucose stimulus GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071900 regulation of protein serine/threonine kinase activity GO:0090087 regulation of peptide transport GO:0090276 regulation of peptide hormone secretion GO:0097327 response to antineoplastic agent GO:0097421 liver regeneration GO:0097479 synaptic vesicle localization GO:0097480 establishment of synaptic vesicle localization GO:0099003 vesicle-mediated transport in synapse GO:0099504 synaptic vesicle cycle GO:0099531 presynaptic process involved in chemical synaptic transmission GO:0099643 signal release from synapse GO:1901342 regulation of vasculature development GO:1901888 regulation of cell junction assembly GO:1902803 regulation of synaptic vesicle transport GO:1902804 negative regulation of synaptic vesicle transport GO:1903305 regulation of regulated secretory pathway GO:1903306 negative regulation of regulated secretory pathway GO:1903531 negative regulation of secretion by cell GO:1904018 positive regulation of vasculature development GO:1990089 response to nerve growth factor GO:1990090 cellular response to nerve growth factor stimulus GO:2000300 regulation of synaptic vesicle exocytosis GO:2000301 negative regulation of synaptic vesicle exocytosis GO:2001212 regulation of vasculogenesis GO:2001214 positive regulation of vasculogenesis |
Molecular Function |
GO:0003924 GTPase activity GO:0005085 guanyl-nucleotide exchange factor activity GO:0005088 Ras guanyl-nucleotide exchange factor activity GO:0005525 GTP binding GO:0008565 protein transporter activity GO:0017016 Ras GTPase binding GO:0017034 Rap guanyl-nucleotide exchange factor activity GO:0019001 guanyl nucleotide binding GO:0031267 small GTPase binding GO:0032561 guanyl ribonucleotide binding GO:0051020 GTPase binding |
Cellular Component |
GO:0005769 early endosome GO:0005770 late endosome GO:0032045 guanyl-nucleotide exchange factor complex GO:0043209 myelin sheath |
KEGG |
hsa04010 MAPK signaling pathway hsa04014 Ras signaling pathway hsa04015 Rap1 signaling pathway hsa04024 cAMP signaling pathway hsa04062 Chemokine signaling pathway hsa04510 Focal adhesion hsa04530 Tight junction hsa04611 Platelet activation hsa04670 Leukocyte transendothelial migration hsa04720 Long-term potentiation hsa04722 Neurotrophin signaling pathway hsa04972 Pancreatic secretion |
Reactome |
R-HSA-170984: ARMS-mediated activation R-HSA-1280218: Adaptive Immune System R-HSA-422475: Axon guidance R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-186763: Downstream signal transduction R-HSA-2871796: FCERI mediated MAPK activation R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-170968: Frs2-mediated activation R-HSA-179812: GRB2 events in EGFR signaling R-HSA-354194: GRB2 R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-381676: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-109582: Hemostasis R-HSA-2428924: IGF1R signaling cascade R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-74751: Insulin receptor signalling cascade R-HSA-163685: Integration of energy metabolism R-HSA-354192: Integrin alphaIIb beta3 signaling R-HSA-912526: Interleukin receptor SHC signaling R-HSA-451927: Interleukin-2 signaling R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling R-HSA-5674135: MAP2K and MAPK activation R-HSA-5683057: MAPK family signaling cascades R-HSA-5684996: MAPK1/MAPK3 signaling R-HSA-8875555: MET activates RAP1 and RAC1 R-HSA-8875878: MET promotes cell motility R-HSA-1430728: Metabolism R-HSA-375165: NCAM signaling for neurite out-growth R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-6798695: Neutrophil degranulation R-HSA-6802957: Oncogenic MAPK signaling R-HSA-6802955: Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-76009: Platelet Aggregation (Plug Formation) R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-169893: Prolonged ERK activation events R-HSA-5673001: RAF/MAP kinase cascade R-HSA-8853659: RET signaling R-HSA-392517: Rap1 signalling R-HSA-422356: Regulation of insulin secretion R-HSA-180336: SHC1 events in EGFR signaling R-HSA-112412: SOS-mediated signalling R-HSA-162582: Signal Transduction R-HSA-6802952: Signaling by BRAF and RAF fusions R-HSA-177929: Signaling by EGFR R-HSA-372790: Signaling by GPCR R-HSA-74752: Signaling by Insulin receptor R-HSA-449147: Signaling by Interleukins R-HSA-2586552: Signaling by Leptin R-HSA-6806834: Signaling by MET R-HSA-186797: Signaling by PDGF R-HSA-6802949: Signaling by RAS mutants R-HSA-1433557: Signaling by SCF-KIT R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-194138: Signaling by VEGF R-HSA-6802948: Signaling by high-kinase activity BRAF mutants R-HSA-6802946: Signaling by moderate kinase activity BRAF mutants R-HSA-166520: Signalling by NGF R-HSA-187687: Signalling to ERKs R-HSA-167044: Signalling to RAS R-HSA-187706: Signalling to p38 via RIT and RIN R-HSA-4420097: VEGFA-VEGFR2 Pathway R-HSA-5218921: VEGFR2 mediated cell proliferation R-HSA-372708: p130Cas linkage to MAPK signaling for integrins |
Summary | |
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Symbol | RAP1A |
Name | RAP1A, member of RAS oncogene family |
Aliases | KREV-1; SMGP21; C21KG; G-22K; KREV1; GTP-binding protein smg p21A; Ras-related protein Krev-1; Ras-related p ...... |
Chromosomal Location | 1p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RAP1A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between RAP1A and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | RAP1A |
Name | RAP1A, member of RAS oncogene family |
Aliases | KREV-1; SMGP21; C21KG; G-22K; KREV1; GTP-binding protein smg p21A; Ras-related protein Krev-1; Ras-related p ...... |
Chromosomal Location | 1p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of RAP1A in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | RAP1A |
Name | RAP1A, member of RAS oncogene family |
Aliases | KREV-1; SMGP21; C21KG; G-22K; KREV1; GTP-binding protein smg p21A; Ras-related protein Krev-1; Ras-related p ...... |
Chromosomal Location | 1p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RAP1A in various data sets.
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Points in the above scatter plot represent the mutation difference of RAP1A in various data sets.
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Summary | |
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Symbol | RAP1A |
Name | RAP1A, member of RAS oncogene family |
Aliases | KREV-1; SMGP21; C21KG; G-22K; KREV1; GTP-binding protein smg p21A; Ras-related protein Krev-1; Ras-related p ...... |
Chromosomal Location | 1p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RAP1A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | RAP1A |
Name | RAP1A, member of RAS oncogene family |
Aliases | KREV-1; SMGP21; C21KG; G-22K; KREV1; GTP-binding protein smg p21A; Ras-related protein Krev-1; Ras-related p ...... |
Chromosomal Location | 1p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RAP1A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RAP1A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | RAP1A |
Name | RAP1A, member of RAS oncogene family |
Aliases | KREV-1; SMGP21; C21KG; G-22K; KREV1; GTP-binding protein smg p21A; Ras-related protein Krev-1; Ras-related p ...... |
Chromosomal Location | 1p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RAP1A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | RAP1A |
Name | RAP1A, member of RAS oncogene family |
Aliases | KREV-1; SMGP21; C21KG; G-22K; KREV1; GTP-binding protein smg p21A; Ras-related protein Krev-1; Ras-related p ...... |
Chromosomal Location | 1p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RAP1A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | RAP1A |
Name | RAP1A, member of RAS oncogene family |
Aliases | KREV-1; SMGP21; C21KG; G-22K; KREV1; GTP-binding protein smg p21A; Ras-related protein Krev-1; Ras-related p ...... |
Chromosomal Location | 1p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RAP1A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | RAP1A |
Name | RAP1A, member of RAS oncogene family |
Aliases | KREV-1; SMGP21; C21KG; G-22K; KREV1; GTP-binding protein smg p21A; Ras-related protein Krev-1; Ras-related p ...... |
Chromosomal Location | 1p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting RAP1A collected from DrugBank database. |
There is no record. |