Summary | |
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Symbol | RAP1GAP2 |
Name | RAP1 GTPase activating protein 2 |
Aliases | KIAA1039; GARNL4; GTPase activating RANGAP domain-like 4; GTPase activating Rap/RanGAP domain-like 4; RAP1GA ...... |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Cytoplasm, perinuclear region |
Domain |
PF02145 Rap/ran-GAP |
Function |
GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. |
Biological Process |
GO:0008361 regulation of cell size GO:0010721 negative regulation of cell development GO:0010975 regulation of neuron projection development GO:0010977 negative regulation of neuron projection development GO:0031345 negative regulation of cell projection organization GO:0032535 regulation of cellular component size GO:0045665 negative regulation of neuron differentiation GO:0050768 negative regulation of neurogenesis GO:0051056 regulation of small GTPase mediated signal transduction GO:0051961 negative regulation of nervous system development GO:0090066 regulation of anatomical structure size |
Molecular Function |
GO:0005096 GTPase activator activity GO:0008047 enzyme activator activity GO:0030695 GTPase regulator activity GO:0060589 nucleoside-triphosphatase regulator activity |
Cellular Component |
GO:0005635 nuclear envelope GO:0005813 centrosome GO:0031965 nuclear membrane |
KEGG | - |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-168256: Immune System R-HSA-392517: Rap1 signalling |
Summary | |
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Symbol | RAP1GAP2 |
Name | RAP1 GTPase activating protein 2 |
Aliases | KIAA1039; GARNL4; GTPase activating RANGAP domain-like 4; GTPase activating Rap/RanGAP domain-like 4; RAP1GA ...... |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RAP1GAP2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | RAP1GAP2 |
Name | RAP1 GTPase activating protein 2 |
Aliases | KIAA1039; GARNL4; GTPase activating RANGAP domain-like 4; GTPase activating Rap/RanGAP domain-like 4; RAP1GA ...... |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of RAP1GAP2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | RAP1GAP2 |
Name | RAP1 GTPase activating protein 2 |
Aliases | KIAA1039; GARNL4; GTPase activating RANGAP domain-like 4; GTPase activating Rap/RanGAP domain-like 4; RAP1GA ...... |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RAP1GAP2 in various data sets.
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Points in the above scatter plot represent the mutation difference of RAP1GAP2 in various data sets.
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Summary | |
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Symbol | RAP1GAP2 |
Name | RAP1 GTPase activating protein 2 |
Aliases | KIAA1039; GARNL4; GTPase activating RANGAP domain-like 4; GTPase activating Rap/RanGAP domain-like 4; RAP1GA ...... |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RAP1GAP2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | RAP1GAP2 |
Name | RAP1 GTPase activating protein 2 |
Aliases | KIAA1039; GARNL4; GTPase activating RANGAP domain-like 4; GTPase activating Rap/RanGAP domain-like 4; RAP1GA ...... |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RAP1GAP2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RAP1GAP2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | RAP1GAP2 |
Name | RAP1 GTPase activating protein 2 |
Aliases | KIAA1039; GARNL4; GTPase activating RANGAP domain-like 4; GTPase activating Rap/RanGAP domain-like 4; RAP1GA ...... |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RAP1GAP2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | RAP1GAP2 |
Name | RAP1 GTPase activating protein 2 |
Aliases | KIAA1039; GARNL4; GTPase activating RANGAP domain-like 4; GTPase activating Rap/RanGAP domain-like 4; RAP1GA ...... |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RAP1GAP2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | RAP1GAP2 |
Name | RAP1 GTPase activating protein 2 |
Aliases | KIAA1039; GARNL4; GTPase activating RANGAP domain-like 4; GTPase activating Rap/RanGAP domain-like 4; RAP1GA ...... |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RAP1GAP2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | RAP1GAP2 |
Name | RAP1 GTPase activating protein 2 |
Aliases | KIAA1039; GARNL4; GTPase activating RANGAP domain-like 4; GTPase activating Rap/RanGAP domain-like 4; RAP1GA ...... |
Chromosomal Location | 17p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting RAP1GAP2 collected from DrugBank database. |
There is no record. |