Summary | |
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Symbol | RASGRP3 |
Name | RAS guanyl releasing protein 3 (calcium and DAG-regulated) |
Aliases | KIAA0846; GRP3; calcium and DAG-regulated guanine nucleotide exchange factor III; Ras guanyl-releasing prote ...... |
Chromosomal Location | 2p25.1-p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain) PF13202 EF hand PF00617 RasGEF domain |
Function |
Guanine nucleotide exchange factor (GEF) for Ras and Rap1. |
Biological Process |
GO:0007265 Ras protein signal transduction |
Molecular Function |
GO:0005085 guanyl-nucleotide exchange factor activity GO:0005088 Ras guanyl-nucleotide exchange factor activity GO:0005096 GTPase activator activity GO:0008047 enzyme activator activity GO:0017016 Ras GTPase binding GO:0019992 diacylglycerol binding GO:0030695 GTPase regulator activity GO:0031267 small GTPase binding GO:0051020 GTPase binding GO:0060589 nucleoside-triphosphatase regulator activity |
Cellular Component |
GO:0032045 guanyl-nucleotide exchange factor complex |
KEGG |
hsa04010 MAPK signaling pathway hsa04014 Ras signaling pathway hsa04015 Rap1 signaling pathway hsa04662 B cell receptor signaling pathway |
Reactome |
R-HSA-170984: ARMS-mediated activation R-HSA-1169092: Activation of RAS in B cells R-HSA-1280218: Adaptive Immune System R-HSA-422475: Axon guidance R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-1266738: Developmental Biology R-HSA-186763: Downstream signal transduction R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR) R-HSA-2871796: FCERI mediated MAPK activation R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-170968: Frs2-mediated activation R-HSA-179812: GRB2 events in EGFR signaling R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-2428924: IGF1R signaling cascade R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-74751: Insulin receptor signalling cascade R-HSA-912526: Interleukin receptor SHC signaling R-HSA-451927: Interleukin-2 signaling R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling R-HSA-5683057: MAPK family signaling cascades R-HSA-5684996: MAPK1/MAPK3 signaling R-HSA-375165: NCAM signaling for neurite out-growth R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-169893: Prolonged ERK activation events R-HSA-5673001: RAF/MAP kinase cascade R-HSA-8853659: RET signaling R-HSA-180336: SHC1 events in EGFR signaling R-HSA-112412: SOS-mediated signalling R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-372790: Signaling by GPCR R-HSA-74752: Signaling by Insulin receptor R-HSA-449147: Signaling by Interleukins R-HSA-2586552: Signaling by Leptin R-HSA-186797: Signaling by PDGF R-HSA-1433557: Signaling by SCF-KIT R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-194138: Signaling by VEGF R-HSA-983705: Signaling by the B Cell Receptor (BCR) R-HSA-166520: Signalling by NGF R-HSA-187687: Signalling to ERKs R-HSA-167044: Signalling to RAS R-HSA-187706: Signalling to p38 via RIT and RIN R-HSA-4420097: VEGFA-VEGFR2 Pathway R-HSA-5218921: VEGFR2 mediated cell proliferation |
Summary | |
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Symbol | RASGRP3 |
Name | RAS guanyl releasing protein 3 (calcium and DAG-regulated) |
Aliases | KIAA0846; GRP3; calcium and DAG-regulated guanine nucleotide exchange factor III; Ras guanyl-releasing prote ...... |
Chromosomal Location | 2p25.1-p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RASGRP3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | RASGRP3 |
Name | RAS guanyl releasing protein 3 (calcium and DAG-regulated) |
Aliases | KIAA0846; GRP3; calcium and DAG-regulated guanine nucleotide exchange factor III; Ras guanyl-releasing prote ...... |
Chromosomal Location | 2p25.1-p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of RASGRP3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | RASGRP3 |
Name | RAS guanyl releasing protein 3 (calcium and DAG-regulated) |
Aliases | KIAA0846; GRP3; calcium and DAG-regulated guanine nucleotide exchange factor III; Ras guanyl-releasing prote ...... |
Chromosomal Location | 2p25.1-p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RASGRP3 in various data sets.
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Points in the above scatter plot represent the mutation difference of RASGRP3 in various data sets.
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Summary | |
---|---|
Symbol | RASGRP3 |
Name | RAS guanyl releasing protein 3 (calcium and DAG-regulated) |
Aliases | KIAA0846; GRP3; calcium and DAG-regulated guanine nucleotide exchange factor III; Ras guanyl-releasing prote ...... |
Chromosomal Location | 2p25.1-p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RASGRP3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | RASGRP3 |
Name | RAS guanyl releasing protein 3 (calcium and DAG-regulated) |
Aliases | KIAA0846; GRP3; calcium and DAG-regulated guanine nucleotide exchange factor III; Ras guanyl-releasing prote ...... |
Chromosomal Location | 2p25.1-p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RASGRP3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RASGRP3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | RASGRP3 |
Name | RAS guanyl releasing protein 3 (calcium and DAG-regulated) |
Aliases | KIAA0846; GRP3; calcium and DAG-regulated guanine nucleotide exchange factor III; Ras guanyl-releasing prote ...... |
Chromosomal Location | 2p25.1-p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RASGRP3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | RASGRP3 |
Name | RAS guanyl releasing protein 3 (calcium and DAG-regulated) |
Aliases | KIAA0846; GRP3; calcium and DAG-regulated guanine nucleotide exchange factor III; Ras guanyl-releasing prote ...... |
Chromosomal Location | 2p25.1-p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RASGRP3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | RASGRP3 |
Name | RAS guanyl releasing protein 3 (calcium and DAG-regulated) |
Aliases | KIAA0846; GRP3; calcium and DAG-regulated guanine nucleotide exchange factor III; Ras guanyl-releasing prote ...... |
Chromosomal Location | 2p25.1-p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RASGRP3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | RASGRP3 |
Name | RAS guanyl releasing protein 3 (calcium and DAG-regulated) |
Aliases | KIAA0846; GRP3; calcium and DAG-regulated guanine nucleotide exchange factor III; Ras guanyl-releasing prote ...... |
Chromosomal Location | 2p25.1-p24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting RASGRP3 collected from DrugBank database. |
There is no record. |