Browse RASGRP3

Summary
SymbolRASGRP3
NameRAS guanyl releasing protein 3 (calcium and DAG-regulated)
Aliases KIAA0846; GRP3; calcium and DAG-regulated guanine nucleotide exchange factor III; Ras guanyl-releasing prote ......
Chromosomal Location2p25.1-p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain)
PF13202 EF hand
PF00617 RasGEF domain
Function

Guanine nucleotide exchange factor (GEF) for Ras and Rap1.

> Gene Ontology
 
Biological Process GO:0007265 Ras protein signal transduction
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0008047 enzyme activator activity
GO:0017016 Ras GTPase binding
GO:0019992 diacylglycerol binding
GO:0030695 GTPase regulator activity
GO:0031267 small GTPase binding
GO:0051020 GTPase binding
GO:0060589 nucleoside-triphosphatase regulator activity
Cellular Component GO:0032045 guanyl-nucleotide exchange factor complex
> KEGG and Reactome Pathway
 
KEGG hsa04010 MAPK signaling pathway
hsa04014 Ras signaling pathway
hsa04015 Rap1 signaling pathway
hsa04662 B cell receptor signaling pathway
Reactome R-HSA-170984: ARMS-mediated activation
R-HSA-1169092: Activation of RAS in B cells
R-HSA-1280218: Adaptive Immune System
R-HSA-422475: Axon guidance
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-2172127: DAP12 interactions
R-HSA-2424491: DAP12 signaling
R-HSA-1266738: Developmental Biology
R-HSA-186763: Downstream signal transduction
R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR)
R-HSA-2871796: FCERI mediated MAPK activation
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-170968: Frs2-mediated activation
R-HSA-179812: GRB2 events in EGFR signaling
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-2428924: IGF1R signaling cascade
R-HSA-112399: IRS-mediated signalling
R-HSA-2428928: IRS-related events triggered by IGF1R
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-74751: Insulin receptor signalling cascade
R-HSA-912526: Interleukin receptor SHC signaling
R-HSA-451927: Interleukin-2 signaling
R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling
R-HSA-5683057: MAPK family signaling cascades
R-HSA-5684996: MAPK1/MAPK3 signaling
R-HSA-375165: NCAM signaling for neurite out-growth
R-HSA-187037: NGF signalling via TRKA from the plasma membrane
R-HSA-169893: Prolonged ERK activation events
R-HSA-5673001: RAF/MAP kinase cascade
R-HSA-8853659: RET signaling
R-HSA-180336: SHC1 events in EGFR signaling
R-HSA-112412: SOS-mediated signalling
R-HSA-162582: Signal Transduction
R-HSA-177929: Signaling by EGFR
R-HSA-372790: Signaling by GPCR
R-HSA-74752: Signaling by Insulin receptor
R-HSA-449147: Signaling by Interleukins
R-HSA-2586552: Signaling by Leptin
R-HSA-186797: Signaling by PDGF
R-HSA-1433557: Signaling by SCF-KIT
R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-194138: Signaling by VEGF
R-HSA-983705: Signaling by the B Cell Receptor (BCR)
R-HSA-166520: Signalling by NGF
R-HSA-187687: Signalling to ERKs
R-HSA-167044: Signalling to RAS
R-HSA-187706: Signalling to p38 via RIT and RIN
R-HSA-4420097: VEGFA-VEGFR2 Pathway
R-HSA-5218921: VEGFR2 mediated cell proliferation
Summary
SymbolRASGRP3
NameRAS guanyl releasing protein 3 (calcium and DAG-regulated)
Aliases KIAA0846; GRP3; calcium and DAG-regulated guanine nucleotide exchange factor III; Ras guanyl-releasing prote ......
Chromosomal Location2p25.1-p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between RASGRP3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolRASGRP3
NameRAS guanyl releasing protein 3 (calcium and DAG-regulated)
Aliases KIAA0846; GRP3; calcium and DAG-regulated guanine nucleotide exchange factor III; Ras guanyl-releasing prote ......
Chromosomal Location2p25.1-p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of RASGRP3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolRASGRP3
NameRAS guanyl releasing protein 3 (calcium and DAG-regulated)
Aliases KIAA0846; GRP3; calcium and DAG-regulated guanine nucleotide exchange factor III; Ras guanyl-releasing prote ......
Chromosomal Location2p25.1-p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of RASGRP3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.8240.0385
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.0940.289
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.6360.486
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0140.966
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2130.884
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3040.872
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0530.917
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.6930.625
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.7160.662
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2840.784
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.8570.599
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2180.0454
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of RASGRP3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.72.711
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.55.93.61
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.79.1-1.41
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.63.7-1.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolRASGRP3
NameRAS guanyl releasing protein 3 (calcium and DAG-regulated)
Aliases KIAA0846; GRP3; calcium and DAG-regulated guanine nucleotide exchange factor III; Ras guanyl-releasing prote ......
Chromosomal Location2p25.1-p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RASGRP3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolRASGRP3
NameRAS guanyl releasing protein 3 (calcium and DAG-regulated)
Aliases KIAA0846; GRP3; calcium and DAG-regulated guanine nucleotide exchange factor III; Ras guanyl-releasing prote ......
Chromosomal Location2p25.1-p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RASGRP3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RASGRP3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolRASGRP3
NameRAS guanyl releasing protein 3 (calcium and DAG-regulated)
Aliases KIAA0846; GRP3; calcium and DAG-regulated guanine nucleotide exchange factor III; Ras guanyl-releasing prote ......
Chromosomal Location2p25.1-p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RASGRP3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolRASGRP3
NameRAS guanyl releasing protein 3 (calcium and DAG-regulated)
Aliases KIAA0846; GRP3; calcium and DAG-regulated guanine nucleotide exchange factor III; Ras guanyl-releasing prote ......
Chromosomal Location2p25.1-p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of RASGRP3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolRASGRP3
NameRAS guanyl releasing protein 3 (calcium and DAG-regulated)
Aliases KIAA0846; GRP3; calcium and DAG-regulated guanine nucleotide exchange factor III; Ras guanyl-releasing prote ......
Chromosomal Location2p25.1-p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between RASGRP3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolRASGRP3
NameRAS guanyl releasing protein 3 (calcium and DAG-regulated)
Aliases KIAA0846; GRP3; calcium and DAG-regulated guanine nucleotide exchange factor III; Ras guanyl-releasing prote ......
Chromosomal Location2p25.1-p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting RASGRP3 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.