Browse RB1CC1

Summary
SymbolRB1CC1
NameRB1-inducible coiled-coil 1
Aliases KIAA0203; Cc1; DRAGOU14; FIP200; ATG17; PPP1R131; 200 kDa FAK family kinase-interacting protein; phosphatase ......
Chromosomal Location8q11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Cytoplasm Cytoplasm, cytosol Preautophagosomal structure Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome.
Domain PF10377 Autophagy-related protein 11
Function

Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity).

> Gene Ontology
 
Biological Process GO:0000045 autophagosome assembly
GO:0000422 mitophagy
GO:0001889 liver development
GO:0006914 autophagy
GO:0006995 cellular response to nitrogen starvation
GO:0007031 peroxisome organization
GO:0007033 vacuole organization
GO:0007254 JNK cascade
GO:0007507 heart development
GO:0008361 regulation of cell size
GO:0009267 cellular response to starvation
GO:0009991 response to extracellular stimulus
GO:0016236 macroautophagy
GO:0030242 pexophagy
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031667 response to nutrient levels
GO:0031668 cellular response to extracellular stimulus
GO:0031669 cellular response to nutrient levels
GO:0032535 regulation of cellular component size
GO:0032872 regulation of stress-activated MAPK cascade
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0042594 response to starvation
GO:0043410 positive regulation of MAPK cascade
GO:0043562 cellular response to nitrogen levels
GO:0045793 positive regulation of cell size
GO:0046328 regulation of JNK cascade
GO:0046330 positive regulation of JNK cascade
GO:0048732 gland development
GO:0051403 stress-activated MAPK cascade
GO:0061008 hepaticobiliary system development
GO:0061709 reticulophagy
GO:0061723 glycophagy
GO:0061726 mitochondrion disassembly
GO:0070302 regulation of stress-activated protein kinase signaling cascade
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade
GO:0071496 cellular response to external stimulus
GO:0090066 regulation of anatomical structure size
GO:0097191 extrinsic apoptotic signaling pathway
GO:1903008 organelle disassembly
GO:1905037 autophagosome organization
GO:2001233 regulation of apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001236 regulation of extrinsic apoptotic signaling pathway
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Molecular Function GO:0032947 protein complex scaffold
Cellular Component GO:0000407 pre-autophagosomal structure
GO:0005635 nuclear envelope
GO:0031965 nuclear membrane
GO:0034045 pre-autophagosomal structure membrane
GO:0061695 transferase complex, transferring phosphorus-containing groups
GO:1902554 serine/threonine protein kinase complex
GO:1902911 protein kinase complex
GO:1990316 ATG1/ULK1 kinase complex
> KEGG and Reactome Pathway
 
KEGG hsa04140 Regulation of autophagy
Reactome R-HSA-2262752: Cellular responses to stress
R-HSA-1632852: Macroautophagy
Summary
SymbolRB1CC1
NameRB1-inducible coiled-coil 1
Aliases KIAA0203; Cc1; DRAGOU14; FIP200; ATG17; PPP1R131; 200 kDa FAK family kinase-interacting protein; phosphatase ......
Chromosomal Location8q11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between RB1CC1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between RB1CC1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
22082959Breast CarcinomaPromote immunityIn our recent study, we show that conditional knockout (KO) of FIP200 in the well-characterized MMTV-PyMT mouse model of human breast cancer significantly suppresses mammary tumorigenesis and progression. In addition to the intrinsic defects in proliferation of FIP200-null tumor cells, we also showed that FIP200 deletion in mammary tumor cells triggers increased host anti-tumor immune surveillance, which also contributes to the decreased mammary tumorigenesis and progression.
Summary
SymbolRB1CC1
NameRB1-inducible coiled-coil 1
Aliases KIAA0203; Cc1; DRAGOU14; FIP200; ATG17; PPP1R131; 200 kDa FAK family kinase-interacting protein; phosphatase ......
Chromosomal Location8q11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of RB1CC1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolRB1CC1
NameRB1-inducible coiled-coil 1
Aliases KIAA0203; Cc1; DRAGOU14; FIP200; ATG17; PPP1R131; 200 kDa FAK family kinase-interacting protein; phosphatase ......
Chromosomal Location8q11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of RB1CC1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.2430.405
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.4790.75
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0760.949
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0780.833
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0480.983
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.1130.969
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.090.839
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0120.995
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1380.949
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0860.929
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.0170.455
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0870.182
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of RB1CC1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.8014.80.00448
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.8014.80.00826
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.4015.40.482
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916012.5-12.50.52
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.907.90.26
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221313.6013.60.279
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolRB1CC1
NameRB1-inducible coiled-coil 1
Aliases KIAA0203; Cc1; DRAGOU14; FIP200; ATG17; PPP1R131; 200 kDa FAK family kinase-interacting protein; phosphatase ......
Chromosomal Location8q11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RB1CC1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolRB1CC1
NameRB1-inducible coiled-coil 1
Aliases KIAA0203; Cc1; DRAGOU14; FIP200; ATG17; PPP1R131; 200 kDa FAK family kinase-interacting protein; phosphatase ......
Chromosomal Location8q11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RB1CC1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RB1CC1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolRB1CC1
NameRB1-inducible coiled-coil 1
Aliases KIAA0203; Cc1; DRAGOU14; FIP200; ATG17; PPP1R131; 200 kDa FAK family kinase-interacting protein; phosphatase ......
Chromosomal Location8q11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RB1CC1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolRB1CC1
NameRB1-inducible coiled-coil 1
Aliases KIAA0203; Cc1; DRAGOU14; FIP200; ATG17; PPP1R131; 200 kDa FAK family kinase-interacting protein; phosphatase ......
Chromosomal Location8q11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of RB1CC1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolRB1CC1
NameRB1-inducible coiled-coil 1
Aliases KIAA0203; Cc1; DRAGOU14; FIP200; ATG17; PPP1R131; 200 kDa FAK family kinase-interacting protein; phosphatase ......
Chromosomal Location8q11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between RB1CC1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolRB1CC1
NameRB1-inducible coiled-coil 1
Aliases KIAA0203; Cc1; DRAGOU14; FIP200; ATG17; PPP1R131; 200 kDa FAK family kinase-interacting protein; phosphatase ......
Chromosomal Location8q11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting RB1CC1 collected from DrugBank database.
> Drugs from DrugBank database
 

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