Summary | |
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Symbol | RBPJ |
Name | recombination signal binding protein for immunoglobulin kappa J region |
Aliases | IGKJRB; RBPJK; KBF2; RBP-J; CBF1; suppressor of hairless homolog (Drosophila); IGKJRB1; RBPSUH; recombining ...... |
Chromosomal Location | 4p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. Cytoplasm. Note=Mainly nuclear, upon interaction with RITA/C12orf52, translocates to the cytoplasm, down-regulating the Notch signaling pathway. |
Domain |
PF09270 Beta-trefoil DNA-binding domain PF09271 LAG1 |
Function |
Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA (PubMed:21991380). Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (PubMed:23303788). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (By similarity). |
Biological Process |
GO:0001503 ossification GO:0001525 angiogenesis GO:0001666 response to hypoxia GO:0001701 in utero embryonic development GO:0001708 cell fate specification GO:0001756 somitogenesis GO:0001773 myeloid dendritic cell activation GO:0001837 epithelial to mesenchymal transition GO:0001890 placenta development GO:0001892 embryonic placenta development GO:0001942 hair follicle development GO:0001974 blood vessel remodeling GO:0002065 columnar/cuboidal epithelial cell differentiation GO:0002274 myeloid leukocyte activation GO:0002437 inflammatory response to antigenic stimulus GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0003002 regionalization GO:0003007 heart morphogenesis GO:0003128 heart field specification GO:0003139 secondary heart field specification GO:0003151 outflow tract morphogenesis GO:0003157 endocardium development GO:0003158 endothelium development GO:0003159 morphogenesis of an endothelium GO:0003160 endocardium morphogenesis GO:0003197 endocardial cushion development GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003203 endocardial cushion morphogenesis GO:0003205 cardiac chamber development GO:0003206 cardiac chamber morphogenesis GO:0003208 cardiac ventricle morphogenesis GO:0003214 cardiac left ventricle morphogenesis GO:0003222 ventricular trabecula myocardium morphogenesis GO:0003229 ventricular cardiac muscle tissue development GO:0003231 cardiac ventricle development GO:0003256 regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation GO:0003272 endocardial cushion formation GO:0003306 Wnt signaling pathway involved in heart development GO:0003307 regulation of Wnt signaling pathway involved in heart development GO:0006310 DNA recombination GO:0006352 DNA-templated transcription, initiation GO:0006367 transcription initiation from RNA polymerase II promoter GO:0006959 humoral immune response GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007219 Notch signaling pathway GO:0007221 positive regulation of transcription of Notch receptor target GO:0007389 pattern specification process GO:0007423 sensory organ development GO:0007507 heart development GO:0007517 muscle organ development GO:0008544 epidermis development GO:0009306 protein secretion GO:0009912 auditory receptor cell fate commitment GO:0009913 epidermal cell differentiation GO:0009952 anterior/posterior pattern specification GO:0009957 epidermal cell fate specification GO:0010002 cardioblast differentiation GO:0010092 specification of animal organ identity GO:0010453 regulation of cell fate commitment GO:0010455 positive regulation of cell fate commitment GO:0014706 striated muscle tissue development GO:0014855 striated muscle cell proliferation GO:0016055 Wnt signaling pathway GO:0016202 regulation of striated muscle tissue development GO:0019827 stem cell population maintenance GO:0021536 diencephalon development GO:0021700 developmental maturation GO:0021983 pituitary gland development GO:0022404 molting cycle process GO:0022405 hair cycle process GO:0030098 lymphocyte differentiation GO:0030099 myeloid cell differentiation GO:0030111 regulation of Wnt signaling pathway GO:0030177 positive regulation of Wnt signaling pathway GO:0030183 B cell differentiation GO:0030216 keratinocyte differentiation GO:0030278 regulation of ossification GO:0030279 negative regulation of ossification GO:0030323 respiratory tube development GO:0030324 lung development GO:0030509 BMP signaling pathway GO:0030510 regulation of BMP signaling pathway GO:0030513 positive regulation of BMP signaling pathway GO:0030900 forebrain development GO:0032633 interleukin-4 production GO:0033002 muscle cell proliferation GO:0035019 somatic stem cell population maintenance GO:0035051 cardiocyte differentiation GO:0035239 tube morphogenesis GO:0035265 organ growth GO:0035270 endocrine system development GO:0035282 segmentation GO:0035315 hair cell differentiation GO:0035904 aorta development GO:0035907 dorsal aorta development GO:0035909 aorta morphogenesis GO:0035912 dorsal aorta morphogenesis GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036293 response to decreased oxygen levels GO:0036294 cellular response to decreased oxygen levels GO:0036302 atrioventricular canal development GO:0038127 ERBB signaling pathway GO:0040034 regulation of development, heterochronic GO:0042113 B cell activation GO:0042303 molting cycle GO:0042490 mechanoreceptor differentiation GO:0042491 auditory receptor cell differentiation GO:0042633 hair cycle GO:0042692 muscle cell differentiation GO:0042693 muscle cell fate commitment GO:0042742 defense response to bacterium GO:0043011 myeloid dendritic cell differentiation GO:0043583 ear development GO:0043588 skin development GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress GO:0043620 regulation of DNA-templated transcription in response to stress GO:0045165 cell fate commitment GO:0045445 myoblast differentiation GO:0045446 endothelial cell differentiation GO:0045844 positive regulation of striated muscle tissue development GO:0045927 positive regulation of growth GO:0046620 regulation of organ growth GO:0046622 positive regulation of organ growth GO:0048013 ephrin receptor signaling pathway GO:0048505 regulation of timing of cell differentiation GO:0048514 blood vessel morphogenesis GO:0048568 embryonic organ development GO:0048608 reproductive structure development GO:0048634 regulation of muscle organ development GO:0048636 positive regulation of muscle organ development GO:0048638 regulation of developmental growth GO:0048639 positive regulation of developmental growth GO:0048644 muscle organ morphogenesis GO:0048645 animal organ formation GO:0048663 neuron fate commitment GO:0048732 gland development GO:0048733 sebaceous gland development GO:0048738 cardiac muscle tissue development GO:0048762 mesenchymal cell differentiation GO:0048771 tissue remodeling GO:0048820 hair follicle maturation GO:0048839 inner ear development GO:0048844 artery morphogenesis GO:0048863 stem cell differentiation GO:0050663 cytokine secretion GO:0051146 striated muscle cell differentiation GO:0051147 regulation of muscle cell differentiation GO:0051149 positive regulation of muscle cell differentiation GO:0051153 regulation of striated muscle cell differentiation GO:0051155 positive regulation of striated muscle cell differentiation GO:0055007 cardiac muscle cell differentiation GO:0055008 cardiac muscle tissue morphogenesis GO:0055010 ventricular cardiac muscle tissue morphogenesis GO:0055017 cardiac muscle tissue growth GO:0055021 regulation of cardiac muscle tissue growth GO:0055023 positive regulation of cardiac muscle tissue growth GO:0055024 regulation of cardiac muscle tissue development GO:0055025 positive regulation of cardiac muscle tissue development GO:0060038 cardiac muscle cell proliferation GO:0060043 regulation of cardiac muscle cell proliferation GO:0060045 positive regulation of cardiac muscle cell proliferation GO:0060070 canonical Wnt signaling pathway GO:0060113 inner ear receptor cell differentiation GO:0060120 inner ear receptor cell fate commitment GO:0060317 cardiac epithelial to mesenchymal transition GO:0060379 cardiac muscle cell myoblast differentiation GO:0060415 muscle tissue morphogenesis GO:0060419 heart growth GO:0060420 regulation of heart growth GO:0060421 positive regulation of heart growth GO:0060428 lung epithelium development GO:0060479 lung cell differentiation GO:0060485 mesenchyme development GO:0060486 Clara cell differentiation GO:0060487 lung epithelial cell differentiation GO:0060537 muscle tissue development GO:0060541 respiratory system development GO:0060562 epithelial tube morphogenesis GO:0060563 neuroepithelial cell differentiation GO:0060674 placenta blood vessel development GO:0060711 labyrinthine layer development GO:0060716 labyrinthine layer blood vessel development GO:0060828 regulation of canonical Wnt signaling pathway GO:0060837 blood vessel endothelial cell differentiation GO:0060839 endothelial cell fate commitment GO:0060840 artery development GO:0060842 arterial endothelial cell differentiation GO:0060844 arterial endothelial cell fate commitment GO:0060846 blood vessel endothelial cell fate commitment GO:0060847 endothelial cell fate specification GO:0060911 cardiac cell fate commitment GO:0060914 heart formation GO:0060923 cardiac muscle cell fate commitment GO:0061053 somite development GO:0061154 endothelial tube morphogenesis GO:0061311 cell surface receptor signaling pathway involved in heart development GO:0061314 Notch signaling involved in heart development GO:0061316 canonical Wnt signaling pathway involved in heart development GO:0061317 canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment GO:0061323 cell proliferation involved in heart morphogenesis GO:0061383 trabecula morphogenesis GO:0061384 heart trabecula morphogenesis GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061458 reproductive system development GO:0070482 response to oxygen levels GO:0071453 cellular response to oxygen levels GO:0071456 cellular response to hypoxia GO:0071695 anatomical structure maturation GO:0071772 response to BMP GO:0071773 cellular response to BMP stimulus GO:0072132 mesenchyme morphogenesis GO:0072148 epithelial cell fate commitment GO:0072554 blood vessel lumenization GO:0072602 interleukin-4 secretion GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090263 positive regulation of canonical Wnt signaling pathway GO:0090287 regulation of cellular response to growth factor stimulus GO:0097028 dendritic cell differentiation GO:0097101 blood vessel endothelial cell fate specification GO:0098542 defense response to other organism GO:0098727 maintenance of cell number GO:0098773 skin epidermis development GO:0198738 cell-cell signaling by wnt GO:1901184 regulation of ERBB signaling pathway GO:1901186 positive regulation of ERBB signaling pathway GO:1901187 regulation of ephrin receptor signaling pathway GO:1901189 positive regulation of ephrin receptor signaling pathway GO:1901213 regulation of transcription from RNA polymerase II promoter involved in heart development GO:1901295 regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment GO:1901297 positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901861 regulation of muscle tissue development GO:1901863 positive regulation of muscle tissue development GO:1905066 regulation of canonical Wnt signaling pathway involved in heart development GO:1905068 positive regulation of canonical Wnt signaling pathway involved in heart development GO:1905207 regulation of cardiocyte differentiation GO:1905209 positive regulation of cardiocyte differentiation GO:2000027 regulation of organ morphogenesis GO:2000136 regulation of cell proliferation involved in heart morphogenesis GO:2000138 positive regulation of cell proliferation involved in heart morphogenesis GO:2000725 regulation of cardiac muscle cell differentiation GO:2000727 positive regulation of cardiac muscle cell differentiation GO:2000826 regulation of heart morphogenesis |
Molecular Function |
GO:0000150 recombinase activity GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001046 core promoter sequence-specific DNA binding GO:0001047 core promoter binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001085 RNA polymerase II transcription factor binding GO:0001103 RNA polymerase II repressing transcription factor binding GO:0001159 core promoter proximal region DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003682 chromatin binding GO:0008134 transcription factor binding GO:0047485 protein N-terminus binding GO:0070491 repressing transcription factor binding |
Cellular Component |
GO:0002193 MAML1-RBP-Jkappa- ICN1 complex GO:0005667 transcription factor complex |
KEGG |
hsa04330 Notch signaling pathway |
Reactome |
R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-157052: NICD traffics to nucleus R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2197563: NOTCH2 intracellular domain regulates transcription R-HSA-350054: Notch-HLH transcription pathway R-HSA-1912422: Pre-NOTCH Expression and Processing R-HSA-1912408: Pre-NOTCH Transcription and Translation R-HSA-186712: Regulation of beta-cell development R-HSA-210744: Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells R-HSA-162582: Signal Transduction R-HSA-157118: Signaling by NOTCH R-HSA-1980143: Signaling by NOTCH1 R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644603: Signaling by NOTCH1 in Cancer R-HSA-1980145: Signaling by NOTCH2 |
Summary | |
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Symbol | RBPJ |
Name | recombination signal binding protein for immunoglobulin kappa J region |
Aliases | IGKJRB; RBPJK; KBF2; RBP-J; CBF1; suppressor of hairless homolog (Drosophila); IGKJRB1; RBPSUH; recombining ...... |
Chromosomal Location | 4p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RBPJ and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between RBPJ and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | RBPJ |
Name | recombination signal binding protein for immunoglobulin kappa J region |
Aliases | IGKJRB; RBPJK; KBF2; RBP-J; CBF1; suppressor of hairless homolog (Drosophila); IGKJRB1; RBPSUH; recombining ...... |
Chromosomal Location | 4p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of RBPJ in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | RBPJ |
Name | recombination signal binding protein for immunoglobulin kappa J region |
Aliases | IGKJRB; RBPJK; KBF2; RBP-J; CBF1; suppressor of hairless homolog (Drosophila); IGKJRB1; RBPSUH; recombining ...... |
Chromosomal Location | 4p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RBPJ in various data sets.
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Points in the above scatter plot represent the mutation difference of RBPJ in various data sets.
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Summary | |
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Symbol | RBPJ |
Name | recombination signal binding protein for immunoglobulin kappa J region |
Aliases | IGKJRB; RBPJK; KBF2; RBP-J; CBF1; suppressor of hairless homolog (Drosophila); IGKJRB1; RBPSUH; recombining ...... |
Chromosomal Location | 4p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RBPJ. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | RBPJ |
Name | recombination signal binding protein for immunoglobulin kappa J region |
Aliases | IGKJRB; RBPJK; KBF2; RBP-J; CBF1; suppressor of hairless homolog (Drosophila); IGKJRB1; RBPSUH; recombining ...... |
Chromosomal Location | 4p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RBPJ. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RBPJ. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | RBPJ |
Name | recombination signal binding protein for immunoglobulin kappa J region |
Aliases | IGKJRB; RBPJK; KBF2; RBP-J; CBF1; suppressor of hairless homolog (Drosophila); IGKJRB1; RBPSUH; recombining ...... |
Chromosomal Location | 4p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RBPJ. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | RBPJ |
Name | recombination signal binding protein for immunoglobulin kappa J region |
Aliases | IGKJRB; RBPJK; KBF2; RBP-J; CBF1; suppressor of hairless homolog (Drosophila); IGKJRB1; RBPSUH; recombining ...... |
Chromosomal Location | 4p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RBPJ expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | RBPJ |
Name | recombination signal binding protein for immunoglobulin kappa J region |
Aliases | IGKJRB; RBPJK; KBF2; RBP-J; CBF1; suppressor of hairless homolog (Drosophila); IGKJRB1; RBPSUH; recombining ...... |
Chromosomal Location | 4p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RBPJ and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | RBPJ |
Name | recombination signal binding protein for immunoglobulin kappa J region |
Aliases | IGKJRB; RBPJK; KBF2; RBP-J; CBF1; suppressor of hairless homolog (Drosophila); IGKJRB1; RBPSUH; recombining ...... |
Chromosomal Location | 4p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting RBPJ collected from DrugBank database. |
There is no record. |