Summary | |
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Symbol | RDM1 |
Name | RAD52 motif containing 1 |
Aliases | MGC33977; RAD52B; RAD52 homolog B (S. cerevisiae); RAD52 motif 1; RAD52 homolog B; RAD52 motif-containing pr ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Cytoplasm Nucleus, nucleolus Note=Isoform 3 and isoform 10 are predominantly nuclear and nucleolar. After treatment with proteasomal inhibitors and mild heat-shock stress, isoform 1, isoform 3, isoform 5, isoform 7, isoform 8 and isoform 10 are relocalized to the nucleolus as dot-like or irregular subnuclear structures. Isoform 1 colocalized with nuclear promyelocytic leukemia (PML) and Cajal bodies (CB); this association with nuclear bodies is enhanced in response to proteotoxic stress. Isoform 3, but not isoform 1 and isoform 5, is relocalized in nucleolar caps during transcriptional arrest.; SUBCELLULAR LOCATION: Isoform 1: Cytoplasm. Nucleus, PML body. Nucleus, Cajal body. Note=Isoform 1 is predominantly cytoplasmic. Isoform 1 colocalized with nuclear promyelocytic leukemia (PML) and Cajal bodies (CB); this association with nuclear bodies is enhanced in response to proteotoxic stress. |
Domain |
PF00076 RNA recognition motif. (a.k.a. RRM |
Function |
May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA. |
Biological Process | - |
Molecular Function | - |
Cellular Component |
GO:0015030 Cajal body GO:0016604 nuclear body GO:0016605 PML body |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | RDM1 |
Name | RAD52 motif containing 1 |
Aliases | MGC33977; RAD52B; RAD52 homolog B (S. cerevisiae); RAD52 motif 1; RAD52 homolog B; RAD52 motif-containing pr ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RDM1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | RDM1 |
Name | RAD52 motif containing 1 |
Aliases | MGC33977; RAD52B; RAD52 homolog B (S. cerevisiae); RAD52 motif 1; RAD52 homolog B; RAD52 motif-containing pr ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of RDM1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | RDM1 |
Name | RAD52 motif containing 1 |
Aliases | MGC33977; RAD52B; RAD52 homolog B (S. cerevisiae); RAD52 motif 1; RAD52 homolog B; RAD52 motif-containing pr ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RDM1 in various data sets.
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Points in the above scatter plot represent the mutation difference of RDM1 in various data sets.
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Summary | |
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Symbol | RDM1 |
Name | RAD52 motif containing 1 |
Aliases | MGC33977; RAD52B; RAD52 homolog B (S. cerevisiae); RAD52 motif 1; RAD52 homolog B; RAD52 motif-containing pr ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RDM1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | RDM1 |
Name | RAD52 motif containing 1 |
Aliases | MGC33977; RAD52B; RAD52 homolog B (S. cerevisiae); RAD52 motif 1; RAD52 homolog B; RAD52 motif-containing pr ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RDM1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RDM1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | RDM1 |
Name | RAD52 motif containing 1 |
Aliases | MGC33977; RAD52B; RAD52 homolog B (S. cerevisiae); RAD52 motif 1; RAD52 homolog B; RAD52 motif-containing pr ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RDM1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | RDM1 |
Name | RAD52 motif containing 1 |
Aliases | MGC33977; RAD52B; RAD52 homolog B (S. cerevisiae); RAD52 motif 1; RAD52 homolog B; RAD52 motif-containing pr ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RDM1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | RDM1 |
Name | RAD52 motif containing 1 |
Aliases | MGC33977; RAD52B; RAD52 homolog B (S. cerevisiae); RAD52 motif 1; RAD52 homolog B; RAD52 motif-containing pr ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RDM1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | RDM1 |
Name | RAD52 motif containing 1 |
Aliases | MGC33977; RAD52B; RAD52 homolog B (S. cerevisiae); RAD52 motif 1; RAD52 homolog B; RAD52 motif-containing pr ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting RDM1 collected from DrugBank database. |
There is no record. |