Summary | |
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Symbol | RECQL4 |
Name | RecQ helicase-like 4 |
Aliases | RecQ4; DNA helicase, RecQ-like type 4; DNA helicase, RecQ-like, type 4; RecQ protein-like 4; ATP-dependent D ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus |
Domain |
PF00270 DEAD/DEAH box helicase PF11719 DNA replication and checkpoint protein PF00271 Helicase conserved C-terminal domain |
Function |
DNA-dependent ATPase. May modulate chromosome segregation. |
Biological Process |
GO:0000733 DNA strand renaturation GO:0006260 DNA replication GO:0006284 base-excision repair GO:0006302 double-strand break repair GO:0006310 DNA recombination GO:0032392 DNA geometric change GO:0032508 DNA duplex unwinding GO:0071103 DNA conformation change |
Molecular Function |
GO:0000217 DNA secondary structure binding GO:0000405 bubble DNA binding GO:0003678 DNA helicase activity GO:0004003 ATP-dependent DNA helicase activity GO:0004386 helicase activity GO:0008026 ATP-dependent helicase activity GO:0008094 DNA-dependent ATPase activity GO:0009378 four-way junction helicase activity GO:0016887 ATPase activity GO:0036310 annealing helicase activity GO:0042623 ATPase activity, coupled GO:0043138 3'-5' DNA helicase activity GO:0043140 ATP-dependent 3'-5' DNA helicase activity GO:0043566 structure-specific DNA binding GO:0070035 purine NTP-dependent helicase activity GO:0097617 annealing activity |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | RECQL4 |
Name | RecQ helicase-like 4 |
Aliases | RecQ4; DNA helicase, RecQ-like type 4; DNA helicase, RecQ-like, type 4; RecQ protein-like 4; ATP-dependent D ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RECQL4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | RECQL4 |
Name | RecQ helicase-like 4 |
Aliases | RecQ4; DNA helicase, RecQ-like type 4; DNA helicase, RecQ-like, type 4; RecQ protein-like 4; ATP-dependent D ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of RECQL4 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | RECQL4 |
Name | RecQ helicase-like 4 |
Aliases | RecQ4; DNA helicase, RecQ-like type 4; DNA helicase, RecQ-like, type 4; RecQ protein-like 4; ATP-dependent D ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RECQL4 in various data sets.
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Points in the above scatter plot represent the mutation difference of RECQL4 in various data sets.
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Summary | |
---|---|
Symbol | RECQL4 |
Name | RecQ helicase-like 4 |
Aliases | RecQ4; DNA helicase, RecQ-like type 4; DNA helicase, RecQ-like, type 4; RecQ protein-like 4; ATP-dependent D ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RECQL4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | RECQL4 |
Name | RecQ helicase-like 4 |
Aliases | RecQ4; DNA helicase, RecQ-like type 4; DNA helicase, RecQ-like, type 4; RecQ protein-like 4; ATP-dependent D ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RECQL4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RECQL4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | RECQL4 |
Name | RecQ helicase-like 4 |
Aliases | RecQ4; DNA helicase, RecQ-like type 4; DNA helicase, RecQ-like, type 4; RecQ protein-like 4; ATP-dependent D ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RECQL4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | RECQL4 |
Name | RecQ helicase-like 4 |
Aliases | RecQ4; DNA helicase, RecQ-like type 4; DNA helicase, RecQ-like, type 4; RecQ protein-like 4; ATP-dependent D ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RECQL4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | RECQL4 |
Name | RecQ helicase-like 4 |
Aliases | RecQ4; DNA helicase, RecQ-like type 4; DNA helicase, RecQ-like, type 4; RecQ protein-like 4; ATP-dependent D ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RECQL4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | RECQL4 |
Name | RecQ helicase-like 4 |
Aliases | RecQ4; DNA helicase, RecQ-like type 4; DNA helicase, RecQ-like, type 4; RecQ protein-like 4; ATP-dependent D ...... |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting RECQL4 collected from DrugBank database. |
There is no record. |