Browse RECQL4

Summary
SymbolRECQL4
NameRecQ helicase-like 4
Aliases RecQ4; DNA helicase, RecQ-like type 4; DNA helicase, RecQ-like, type 4; RecQ protein-like 4; ATP-dependent D ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Nucleus
Domain PF00270 DEAD/DEAH box helicase
PF11719 DNA replication and checkpoint protein
PF00271 Helicase conserved C-terminal domain
Function

DNA-dependent ATPase. May modulate chromosome segregation.

> Gene Ontology
 
Biological Process GO:0000733 DNA strand renaturation
GO:0006260 DNA replication
GO:0006284 base-excision repair
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0032392 DNA geometric change
GO:0032508 DNA duplex unwinding
GO:0071103 DNA conformation change
Molecular Function GO:0000217 DNA secondary structure binding
GO:0000405 bubble DNA binding
GO:0003678 DNA helicase activity
GO:0004003 ATP-dependent DNA helicase activity
GO:0004386 helicase activity
GO:0008026 ATP-dependent helicase activity
GO:0008094 DNA-dependent ATPase activity
GO:0009378 four-way junction helicase activity
GO:0016887 ATPase activity
GO:0036310 annealing helicase activity
GO:0042623 ATPase activity, coupled
GO:0043138 3'-5' DNA helicase activity
GO:0043140 ATP-dependent 3'-5' DNA helicase activity
GO:0043566 structure-specific DNA binding
GO:0070035 purine NTP-dependent helicase activity
GO:0097617 annealing activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolRECQL4
NameRecQ helicase-like 4
Aliases RecQ4; DNA helicase, RecQ-like type 4; DNA helicase, RecQ-like, type 4; RecQ protein-like 4; ATP-dependent D ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between RECQL4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolRECQL4
NameRecQ helicase-like 4
Aliases RecQ4; DNA helicase, RecQ-like type 4; DNA helicase, RecQ-like, type 4; RecQ protein-like 4; ATP-dependent D ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of RECQL4 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.59 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolRECQL4
NameRecQ helicase-like 4
Aliases RecQ4; DNA helicase, RecQ-like type 4; DNA helicase, RecQ-like, type 4; RecQ protein-like 4; ATP-dependent D ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of RECQL4 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.8190.0363
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.3150.336
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.4690.703
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.7340.119
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.9270.689
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.4950.871
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0360.927
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.3980.726
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.5670.635
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.620.175
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 282.4230.148
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.3760.00497
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of RECQL4 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103033.3-33.30.231
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.44.13.30.61
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.45.12.30.647
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.907.90.26
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolRECQL4
NameRecQ helicase-like 4
Aliases RecQ4; DNA helicase, RecQ-like type 4; DNA helicase, RecQ-like, type 4; RecQ protein-like 4; ATP-dependent D ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RECQL4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolRECQL4
NameRecQ helicase-like 4
Aliases RecQ4; DNA helicase, RecQ-like type 4; DNA helicase, RecQ-like, type 4; RecQ protein-like 4; ATP-dependent D ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RECQL4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RECQL4.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolRECQL4
NameRecQ helicase-like 4
Aliases RecQ4; DNA helicase, RecQ-like type 4; DNA helicase, RecQ-like, type 4; RecQ protein-like 4; ATP-dependent D ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RECQL4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolRECQL4
NameRecQ helicase-like 4
Aliases RecQ4; DNA helicase, RecQ-like type 4; DNA helicase, RecQ-like, type 4; RecQ protein-like 4; ATP-dependent D ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of RECQL4 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolRECQL4
NameRecQ helicase-like 4
Aliases RecQ4; DNA helicase, RecQ-like type 4; DNA helicase, RecQ-like, type 4; RecQ protein-like 4; ATP-dependent D ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between RECQL4 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolRECQL4
NameRecQ helicase-like 4
Aliases RecQ4; DNA helicase, RecQ-like type 4; DNA helicase, RecQ-like, type 4; RecQ protein-like 4; ATP-dependent D ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting RECQL4 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.